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Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome.
Am J Gastroenterol 2005; 100(4):896-904AJ

Abstract

BACKGROUND

Due to a wide range of symptom patterns, patients with irritable bowel syndrome (IBS) are often subgrouped by bowel habit. However, the IBS subgroup with alternating bowel habits (IBS-A) has been poorly characterized.

OBJECTIVES

(i) To determine a set of bowel habit symptom criteria, which most specifically identifies IBS patients with an alternating bowel habit, (ii) to describe IBS-A bowel symptom patterns, and (iii) to compare clinical characteristics among IBS-A, constipation-predominant (IBS-C), and diarrhea-predominant IBS (IBS-D).

METHODS

One thousand one hundred and two Rome I positive IBS patients were analyzed. Three sets of potential criteria for IBS-A were developed and compared by multirater Kappa test. Gastrointestinal, psychological, extraintestinal symptoms, and health-related quality of life were compared in IBS-A, IBS-C, and IBS-D using chi(2) test and analysis of variance (ANOVA).

RESULTS

Stool consistency was determined to be the most specific criteria for alternating bowel habits. IBS-A patients reported rapid fluctuations in bowel habits with short symptom flares and remissions. There was a greater prevalence of psychological and extraintestinal symptoms in the IBS-A subgroup compared to IBS-C and IBS-D. No differences were seen between bowel habit subtypes in health-related quality of life.

CONCLUSIONS

IBS-A patients have rapidly fluctuating symptoms and increased psychological comorbidity, which should be taken into account for clinical practice and clinical trials.

Authors+Show Affiliations

CNS/WH: Center for Neurovisceral Sciences & Women's Health, Department of Medicine, UCLA, and the VA Greater Los Angeles Healthcare System, Los Angeles, California, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15784038

Citation

Tillisch, Kirsten, et al. "Characterization of the Alternating Bowel Habit Subtype in Patients With Irritable Bowel Syndrome." The American Journal of Gastroenterology, vol. 100, no. 4, 2005, pp. 896-904.
Tillisch K, Labus JS, Naliboff BD, et al. Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome. Am J Gastroenterol. 2005;100(4):896-904.
Tillisch, K., Labus, J. S., Naliboff, B. D., Bolus, R., Shetzline, M., Mayer, E. A., & Chang, L. (2005). Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome. The American Journal of Gastroenterology, 100(4), pp. 896-904.
Tillisch K, et al. Characterization of the Alternating Bowel Habit Subtype in Patients With Irritable Bowel Syndrome. Am J Gastroenterol. 2005;100(4):896-904. PubMed PMID: 15784038.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Characterization of the alternating bowel habit subtype in patients with irritable bowel syndrome. AU - Tillisch,Kirsten, AU - Labus,Jennifer S, AU - Naliboff,Bruce D, AU - Bolus,Roger, AU - Shetzline,Michael, AU - Mayer,Emeran A, AU - Chang,Lin, PY - 2005/3/24/pubmed PY - 2005/4/30/medline PY - 2005/3/24/entrez SP - 896 EP - 904 JF - The American journal of gastroenterology JO - Am. J. Gastroenterol. VL - 100 IS - 4 N2 - BACKGROUND: Due to a wide range of symptom patterns, patients with irritable bowel syndrome (IBS) are often subgrouped by bowel habit. However, the IBS subgroup with alternating bowel habits (IBS-A) has been poorly characterized. OBJECTIVES: (i) To determine a set of bowel habit symptom criteria, which most specifically identifies IBS patients with an alternating bowel habit, (ii) to describe IBS-A bowel symptom patterns, and (iii) to compare clinical characteristics among IBS-A, constipation-predominant (IBS-C), and diarrhea-predominant IBS (IBS-D). METHODS: One thousand one hundred and two Rome I positive IBS patients were analyzed. Three sets of potential criteria for IBS-A were developed and compared by multirater Kappa test. Gastrointestinal, psychological, extraintestinal symptoms, and health-related quality of life were compared in IBS-A, IBS-C, and IBS-D using chi(2) test and analysis of variance (ANOVA). RESULTS: Stool consistency was determined to be the most specific criteria for alternating bowel habits. IBS-A patients reported rapid fluctuations in bowel habits with short symptom flares and remissions. There was a greater prevalence of psychological and extraintestinal symptoms in the IBS-A subgroup compared to IBS-C and IBS-D. No differences were seen between bowel habit subtypes in health-related quality of life. CONCLUSIONS: IBS-A patients have rapidly fluctuating symptoms and increased psychological comorbidity, which should be taken into account for clinical practice and clinical trials. SN - 0002-9270 UR - https://www.unboundmedicine.com/medline/citation/15784038/Characterization_of_the_alternating_bowel_habit_subtype_in_patients_with_irritable_bowel_syndrome_ L2 - http://Insights.ovid.com/pubmed?pmid=15784038 DB - PRIME DP - Unbound Medicine ER -