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The arthritis of ulcerative colitis: clinical and genetic aspects.
J Rheumatol. 1992 Mar; 19(3):373-7.JR

Abstract

Seventy-nine consecutive patients with active ulcerative colitis were studied to establish the prevalence and clinical features of articular involvement. HLA typing for A and B loci was performed. Forty-nine patients showed an articular involvement (62%). Three different clinical patterns were identified: ankylosing spondylitis occurring in 20 subjects; peripheral arthritis in 15; unclassifiable spondylitis in 14. When compared to the general population in our area, patients with colitis showed a significantly higher prevalence of the HLA-A1 (p less than 0.005), B21 (p less than 0.001) and B27 (p less than 0.05); among patients with colitis, those with arthritis revealed higher frequency of HLA-B27 (p less than 0.05). Our study reveals a high prevalence of unclassifiable spondylitis during ulcerative colitis, and suggests a new approach to the classification of seronegative spondarthritis.

Authors+Show Affiliations

Scarpa R
Department of Internal Medicine, 2nd Medical School, University of Naples, Italy.
del Puente A
No affiliation info available
D'Arienzo A
No affiliation info available
di Girolamo C
No affiliation info available
della Valle G
No affiliation info available
Panarese A
No affiliation info available
Lubrano E
No affiliation info available
Oriente P
No affiliation info available

MeSH

AdolescentAdultAgedArthritisColitis, UlcerativeFemaleHLA AntigensHumansMaleMiddle AgedPrevalenceSpondylitisSpondylitis, Ankylosing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

1578450

Citation

Scarpa, R, et al. "The Arthritis of Ulcerative Colitis: Clinical and Genetic Aspects." The Journal of Rheumatology, vol. 19, no. 3, 1992, pp. 373-7.
Scarpa R, del Puente A, D'Arienzo A, et al. The arthritis of ulcerative colitis: clinical and genetic aspects. J Rheumatol. 1992;19(3):373-7.
Scarpa, R., del Puente, A., D'Arienzo, A., di Girolamo, C., della Valle, G., Panarese, A., Lubrano, E., & Oriente, P. (1992). The arthritis of ulcerative colitis: clinical and genetic aspects. The Journal of Rheumatology, 19(3), 373-7.
Scarpa R, et al. The Arthritis of Ulcerative Colitis: Clinical and Genetic Aspects. J Rheumatol. 1992;19(3):373-7. PubMed PMID: 1578450.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The arthritis of ulcerative colitis: clinical and genetic aspects. AU - Scarpa,R, AU - del Puente,A, AU - D'Arienzo,A, AU - di Girolamo,C, AU - della Valle,G, AU - Panarese,A, AU - Lubrano,E, AU - Oriente,P, PY - 1992/3/1/pubmed PY - 1992/3/1/medline PY - 1992/3/1/entrez SP - 373 EP - 7 JF - The Journal of rheumatology JO - J Rheumatol VL - 19 IS - 3 N2 - Seventy-nine consecutive patients with active ulcerative colitis were studied to establish the prevalence and clinical features of articular involvement. HLA typing for A and B loci was performed. Forty-nine patients showed an articular involvement (62%). Three different clinical patterns were identified: ankylosing spondylitis occurring in 20 subjects; peripheral arthritis in 15; unclassifiable spondylitis in 14. When compared to the general population in our area, patients with colitis showed a significantly higher prevalence of the HLA-A1 (p less than 0.005), B21 (p less than 0.001) and B27 (p less than 0.05); among patients with colitis, those with arthritis revealed higher frequency of HLA-B27 (p less than 0.05). Our study reveals a high prevalence of unclassifiable spondylitis during ulcerative colitis, and suggests a new approach to the classification of seronegative spondarthritis. SN - 0315-162X UR - https://www.unboundmedicine.com/medline/citation/1578450/The_arthritis_of_ulcerative_colitis:_clinical_and_genetic_aspects_ DB - PRIME DP - Unbound Medicine ER -