Tags

Type your tag names separated by a space and hit enter

Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat.
Neuropsychopharmacology. 2005 Oct; 30(10):1870-82.N

Abstract

This study investigated long-term behavioral, neurochemical, and neuropharmacological effects of ethanol-(+/-)-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) combinations. Over 4 consecutive days, male Long-Evans rats received 1.5 g/kg ethanol and/or 10 mg/kg MDMA, or saline. Rectal temperatures were taken in some rats. Starting 4 days after the last injection, we tested working memory, sensory-motor coordination, and anxiety. Subsequently, we measured cortical, striatal, septal, and hippocampal monoamines (last MDMA injection-euthanasia delay: 20 days), or electrically evoked release of serotonin (5-HT) in cortical and hippocampal slices, and its modulation in the presence of CP 93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrollo[3,2-b]pyrid-5-one) or methiotepin (last MDMA injection-euthanasia delays: 3-6 weeks). Ethanol attenuated the MDMA-induced hyperthermia, but only on the first day. In the long-term, MDMA reduced 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) content in most brain regions. The behavioral and neurochemical effects of the ethanol-MDMA combination were comparable to those of MDMA alone; sensory-motor coordination was altered after ethanol and/or MDMA. In hippocampal slices from rats given ethanol and MDMA, the CP 93,129-induced inhibition and methiotepin-induced facilitation of 5-HT release were stronger and weaker, respectively, than in the other groups. This is the first study addressing long-term effects of repeated MDMA and EtOH combined treatments in experimental animals. Whereas the drug combination produced the same behavioral and neurochemical effects as MDMA alone, our neuropharmacological results suggest that MDMA-EtOH interactions may have specific long-term consequences on presynaptic modulation of hippocampal 5-HT release, but not necessarily related to MDMA-induced depletion of 5-HT. Thus, it is likely that the psycho(patho)logical problems reported by ecstasy users drinking alcohol are not solely due to the consumption of MDMA.

Authors+Show Affiliations

Laboratoire de Neurosciences Comportementales et Cognitives, UMR 7521, CNRS/Université Louis Pasteur, GDR 2905 CNRS, IFR 37 Neurosciences, 12 rue Goethe, F-67000 Strasbourg, France. jean-christophe.cassel@psycho-ulp.u-strasbg.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15785779

Citation

Cassel, Jean-Christophe, et al. "Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and Their Combination: Long-term Behavioral, Neurochemical and Neuropharmacological Effects in the Rat." Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, vol. 30, no. 10, 2005, pp. 1870-82.
Cassel JC, Riegert C, Rutz S, et al. Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat. Neuropsychopharmacology. 2005;30(10):1870-82.
Cassel, J. C., Riegert, C., Rutz, S., Koenig, J., Rothmaier, K., Cosquer, B., Lazarus, C., Birthelmer, A., Jeltsch, H., Jones, B. C., & Jackisch, R. (2005). Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat. Neuropsychopharmacology : Official Publication of the American College of Neuropsychopharmacology, 30(10), 1870-82.
Cassel JC, et al. Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and Their Combination: Long-term Behavioral, Neurochemical and Neuropharmacological Effects in the Rat. Neuropsychopharmacology. 2005;30(10):1870-82. PubMed PMID: 15785779.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ethanol, 3,4-methylenedioxymethamphetamine (ecstasy) and their combination: long-term behavioral, neurochemical and neuropharmacological effects in the rat. AU - Cassel,Jean-Christophe, AU - Riegert,Céline, AU - Rutz,Susanne, AU - Koenig,Julie, AU - Rothmaier,Katharina, AU - Cosquer,Brigitte, AU - Lazarus,Christine, AU - Birthelmer,Anja, AU - Jeltsch,Hélène, AU - Jones,Byron C, AU - Jackisch,Rolf, PY - 2005/3/24/pubmed PY - 2005/12/13/medline PY - 2005/3/24/entrez SP - 1870 EP - 82 JF - Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology JO - Neuropsychopharmacology VL - 30 IS - 10 N2 - This study investigated long-term behavioral, neurochemical, and neuropharmacological effects of ethanol-(+/-)-3,4-methylenedioxymethamphetamine (MDMA, ecstasy) combinations. Over 4 consecutive days, male Long-Evans rats received 1.5 g/kg ethanol and/or 10 mg/kg MDMA, or saline. Rectal temperatures were taken in some rats. Starting 4 days after the last injection, we tested working memory, sensory-motor coordination, and anxiety. Subsequently, we measured cortical, striatal, septal, and hippocampal monoamines (last MDMA injection-euthanasia delay: 20 days), or electrically evoked release of serotonin (5-HT) in cortical and hippocampal slices, and its modulation in the presence of CP 93,129 (3-(1,2,5,6-tetrahydropyrid-4-yl)pyrrollo[3,2-b]pyrid-5-one) or methiotepin (last MDMA injection-euthanasia delays: 3-6 weeks). Ethanol attenuated the MDMA-induced hyperthermia, but only on the first day. In the long-term, MDMA reduced 5-HT and 5-hydroxyindoleacetic acid (5-HIAA) content in most brain regions. The behavioral and neurochemical effects of the ethanol-MDMA combination were comparable to those of MDMA alone; sensory-motor coordination was altered after ethanol and/or MDMA. In hippocampal slices from rats given ethanol and MDMA, the CP 93,129-induced inhibition and methiotepin-induced facilitation of 5-HT release were stronger and weaker, respectively, than in the other groups. This is the first study addressing long-term effects of repeated MDMA and EtOH combined treatments in experimental animals. Whereas the drug combination produced the same behavioral and neurochemical effects as MDMA alone, our neuropharmacological results suggest that MDMA-EtOH interactions may have specific long-term consequences on presynaptic modulation of hippocampal 5-HT release, but not necessarily related to MDMA-induced depletion of 5-HT. Thus, it is likely that the psycho(patho)logical problems reported by ecstasy users drinking alcohol are not solely due to the consumption of MDMA. SN - 0893-133X UR - https://www.unboundmedicine.com/medline/citation/15785779/Ethanol_34_methylenedioxymethamphetamine__ecstasy__and_their_combination:_long_term_behavioral_neurochemical_and_neuropharmacological_effects_in_the_rat_ L2 - http://dx.doi.org/10.1038/sj.npp.1300714 DB - PRIME DP - Unbound Medicine ER -