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Bronchiolitis with airflow obstruction.
Curr Opin Pulm Med 1995; 1(2):109-18CO

Abstract

Bronchiolar lesions are becoming increasingly recognized as an important cause of airflow obstruction. For this reason, it is helpful to have an update of the current clinical, radiographic, and immunologic perspective. Among the bronchiolar airflow disorders, diffuse panbronchiolitis is related to HLA antigen Bw54, and low-dose, long-term erythromycin appears to be effective therapy. Bronchiolitis obliterans can be classified histologically as constrictive bronchiolitis and as proliferative bronchiolitis obliterans. Idiopathic, postfume, postinfectious, and connective tissue disease bronchiolitis obliterans continue to be rare and often have a poor prognosis. Bronchiolitis obliterans associated with lung transplantation is undergoing intensive investigation with regard to pathogenesis, immunologic study, early detection, and treatment. The lesion appears to be a form of chronic organ rejection. The recognition of the distinctive differences among the bronchiolar airflow disorders by clinicians and clinical investigators is essential for improved patient care, for a greater understanding of the pathogenesis of the disorder, and for development of new therapeutic advances.

Authors+Show Affiliations

Department of Medicine, New England Baptist Hospital and Boston University School of Medicine, Boston, Massachusetts 02120, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15786600

Citation

Epler, G R.. "Bronchiolitis With Airflow Obstruction." Current Opinion in Pulmonary Medicine, vol. 1, no. 2, 1995, pp. 109-18.
Epler GR. Bronchiolitis with airflow obstruction. Curr Opin Pulm Med. 1995;1(2):109-18.
Epler, G. R. (1995). Bronchiolitis with airflow obstruction. Current Opinion in Pulmonary Medicine, 1(2), pp. 109-18.
Epler GR. Bronchiolitis With Airflow Obstruction. Curr Opin Pulm Med. 1995;1(2):109-18. PubMed PMID: 15786600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Bronchiolitis with airflow obstruction. A1 - Epler,G R, PY - 1995/3/1/pubmed PY - 2005/4/20/medline PY - 1995/3/1/entrez SP - 109 EP - 18 JF - Current opinion in pulmonary medicine JO - Curr Opin Pulm Med VL - 1 IS - 2 N2 - Bronchiolar lesions are becoming increasingly recognized as an important cause of airflow obstruction. For this reason, it is helpful to have an update of the current clinical, radiographic, and immunologic perspective. Among the bronchiolar airflow disorders, diffuse panbronchiolitis is related to HLA antigen Bw54, and low-dose, long-term erythromycin appears to be effective therapy. Bronchiolitis obliterans can be classified histologically as constrictive bronchiolitis and as proliferative bronchiolitis obliterans. Idiopathic, postfume, postinfectious, and connective tissue disease bronchiolitis obliterans continue to be rare and often have a poor prognosis. Bronchiolitis obliterans associated with lung transplantation is undergoing intensive investigation with regard to pathogenesis, immunologic study, early detection, and treatment. The lesion appears to be a form of chronic organ rejection. The recognition of the distinctive differences among the bronchiolar airflow disorders by clinicians and clinical investigators is essential for improved patient care, for a greater understanding of the pathogenesis of the disorder, and for development of new therapeutic advances. SN - 1070-5287 UR - https://www.unboundmedicine.com/medline/citation/15786600/Bronchiolitis_with_airflow_obstruction_ DB - PRIME DP - Unbound Medicine ER -