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[Immunophenotyping of acute leukemias: diagnostic and pronostic utility in Abidjan, Côte d'Ivoire].
Bull Soc Pathol Exot. 2004; 97(5):319-22.BS

Abstract

Flow cytometry is nowadays the first-line method for immunophenotypic identification of blast cells but is not so usual in limited-resources countries. We have investigated on the usefulness of this tool in Abidjan, Côte d'Ivoire. Bone marrow sample from 13 patients with acute leukemia identified by cytology and cytochemical analysis was immunophenotyped by using monoclonal antibodies directed to: T lymphoid cells (CD3, CD5, CD7); B lymphoid cells (CD10, CD19, CD20, CD22, HLA-DR) and myeloid cells (CD13, CD33). Immunophenotyping allowed us to confirm the diagnosis of 6 de novo acute leukemias (2 acute myeloid leukaemias, 4 acute lymphoid leukemias) and 7 acute leukaemias resulting from chronic myeloid leukaemias. Immunophenotyping also characterizes the atypical/aberrant lineage essential for the prognosis: 2 biphenotypic acute leukemias (myeloid/lymphoid T) were identified. Our results suggest that flow cytometry may be a useful additional tool to identify the specific leukemic cell, to make a better classification as well as a prognosis evaluation of patients with acute leukemias.

Authors+Show Affiliations

Département d'hématologie, d'immunologie et de biologie cellulaire, Unité de formation et de recherche des sciences pharmaceutiques et biologiques, Université de Cocody, Abidjan, Côte d'Ivoire. ikandre@yahoo.frNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

fre

PubMed ID

15787262

Citation

Inwoley, K A., et al. "[Immunophenotyping of Acute Leukemias: Diagnostic and Pronostic Utility in Abidjan, Côte D'Ivoire]." Bulletin De La Societe De Pathologie Exotique (1990), vol. 97, no. 5, 2004, pp. 319-22.
Inwoley KA, Sawadogo D, Mizero L, et al. [Immunophenotyping of acute leukemias: diagnostic and pronostic utility in Abidjan, Côte d'Ivoire]. Bull Soc Pathol Exot. 2004;97(5):319-22.
Inwoley, K. A., Sawadogo, D., Mizero, L., Salou, M., Karim, N., & Sangaré, A. (2004). [Immunophenotyping of acute leukemias: diagnostic and pronostic utility in Abidjan, Côte d'Ivoire]. Bulletin De La Societe De Pathologie Exotique (1990), 97(5), 319-22.
Inwoley KA, et al. [Immunophenotyping of Acute Leukemias: Diagnostic and Pronostic Utility in Abidjan, Côte D'Ivoire]. Bull Soc Pathol Exot. 2004;97(5):319-22. PubMed PMID: 15787262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Immunophenotyping of acute leukemias: diagnostic and pronostic utility in Abidjan, Côte d'Ivoire]. AU - Inwoley,K A, AU - Sawadogo,D, AU - Mizero,L, AU - Salou,M, AU - Karim,N, AU - Sangaré,A, PY - 2005/3/25/pubmed PY - 2005/5/18/medline PY - 2005/3/25/entrez SP - 319 EP - 22 JF - Bulletin de la Societe de pathologie exotique (1990) JO - Bull Soc Pathol Exot VL - 97 IS - 5 N2 - Flow cytometry is nowadays the first-line method for immunophenotypic identification of blast cells but is not so usual in limited-resources countries. We have investigated on the usefulness of this tool in Abidjan, Côte d'Ivoire. Bone marrow sample from 13 patients with acute leukemia identified by cytology and cytochemical analysis was immunophenotyped by using monoclonal antibodies directed to: T lymphoid cells (CD3, CD5, CD7); B lymphoid cells (CD10, CD19, CD20, CD22, HLA-DR) and myeloid cells (CD13, CD33). Immunophenotyping allowed us to confirm the diagnosis of 6 de novo acute leukemias (2 acute myeloid leukaemias, 4 acute lymphoid leukemias) and 7 acute leukaemias resulting from chronic myeloid leukaemias. Immunophenotyping also characterizes the atypical/aberrant lineage essential for the prognosis: 2 biphenotypic acute leukemias (myeloid/lymphoid T) were identified. Our results suggest that flow cytometry may be a useful additional tool to identify the specific leukemic cell, to make a better classification as well as a prognosis evaluation of patients with acute leukemias. SN - 0037-9085 UR - https://www.unboundmedicine.com/medline/citation/15787262/[Immunophenotyping_of_acute_leukemias:_diagnostic_and_pronostic_utility_in_Abidjan_Côte_d'Ivoire]_ L2 - https://medlineplus.gov/leukemia.html DB - PRIME DP - Unbound Medicine ER -