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Eremophilane-type sesquiterpene derivatives from Senecio aegyptius var. discoideus.
J Nat Prod. 2005 Mar; 68(3):439-42.JN

Abstract

Investigation of a CH(2)Cl(2) extract of the aerial parts of Senecio aegyptius var. discoideus afforded nine eremophilane compounds, of which six are new (1-6), namely, 1beta-hydroxy-8alphaH-eremophil-7(11),9-dien-8beta,12-olide (1), 1beta,8alpha-dihydroxyeremophil-7(11),9-dien-8beta,12-olide (2), 1beta-hydroxy-8alpha-methoxyeremophil-7(11),9-dien-8beta,12-olide (3), 1-oxo-8alpha-methoxy-10alphaH-eremophil-7(11)-en-8beta,12-lactam (4), 1beta,10beta-epoxy-8alpha-hydroxyeremophil-7(11)-en-8beta,12-olide (5), and 1beta,10beta-epoxy-8alpha-methoxyeremophil-7(11)-en-8beta,12-olide (6). The structures of 1-6 were elucidated by spectroscopic methods and by comparison with literature data. The antibacterial activity of the isolated compounds was tested against Bacillus cereus and a Serratia sp.

Authors+Show Affiliations

El-Hamd H Mohamed A
Department of Chemistry, Aswan-Faculty of Science, South Valley University, Aswan, Egypt.
Ahmed AA
No affiliation info available

MeSH

Anti-Bacterial AgentsBacillus cereusCrystallography, X-RayEgyptMicrobial Sensitivity TestsMolecular ConformationMolecular StructureNuclear Magnetic Resonance, BiomolecularPlants, MedicinalSenecioSerratiaSesquiterpenes

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15787455

Citation

El-Hamd H Mohamed, Abou, and Ahmed A. Ahmed. "Eremophilane-type Sesquiterpene Derivatives From Senecio Aegyptius Var. Discoideus." Journal of Natural Products, vol. 68, no. 3, 2005, pp. 439-42.
El-Hamd H Mohamed A, Ahmed AA. Eremophilane-type sesquiterpene derivatives from Senecio aegyptius var. discoideus. J Nat Prod. 2005;68(3):439-42.
El-Hamd H Mohamed, A., & Ahmed, A. A. (2005). Eremophilane-type sesquiterpene derivatives from Senecio aegyptius var. discoideus. Journal of Natural Products, 68(3), 439-42.
El-Hamd H Mohamed A, Ahmed AA. Eremophilane-type Sesquiterpene Derivatives From Senecio Aegyptius Var. Discoideus. J Nat Prod. 2005;68(3):439-42. PubMed PMID: 15787455.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Eremophilane-type sesquiterpene derivatives from Senecio aegyptius var. discoideus. AU - El-Hamd H Mohamed,Abou, AU - Ahmed,Ahmed A, PY - 2005/3/25/pubmed PY - 2005/4/29/medline PY - 2005/3/25/entrez SP - 439 EP - 42 JF - Journal of natural products JO - J Nat Prod VL - 68 IS - 3 N2 - Investigation of a CH(2)Cl(2) extract of the aerial parts of Senecio aegyptius var. discoideus afforded nine eremophilane compounds, of which six are new (1-6), namely, 1beta-hydroxy-8alphaH-eremophil-7(11),9-dien-8beta,12-olide (1), 1beta,8alpha-dihydroxyeremophil-7(11),9-dien-8beta,12-olide (2), 1beta-hydroxy-8alpha-methoxyeremophil-7(11),9-dien-8beta,12-olide (3), 1-oxo-8alpha-methoxy-10alphaH-eremophil-7(11)-en-8beta,12-lactam (4), 1beta,10beta-epoxy-8alpha-hydroxyeremophil-7(11)-en-8beta,12-olide (5), and 1beta,10beta-epoxy-8alpha-methoxyeremophil-7(11)-en-8beta,12-olide (6). The structures of 1-6 were elucidated by spectroscopic methods and by comparison with literature data. The antibacterial activity of the isolated compounds was tested against Bacillus cereus and a Serratia sp. SN - 0163-3864 UR - https://www.unboundmedicine.com/medline/citation/15787455/Eremophilane_type_sesquiterpene_derivatives_from_Senecio_aegyptius_var__discoideus_ DB - PRIME DP - Unbound Medicine ER -