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Polyunsaturated fatty acids and inflammation.
Biochem Soc Trans. 2005 Apr; 33(Pt 2):423-7.BS

Abstract

The n-6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n-3 polyunsaturated fatty acids (found in oily fish and fish oils) results in a partial replacement of the arachidonic acid in cell membranes by eicosapentaenoic and docosahexaenoic acids. This leads to decreased production of arachidonic acid-derived mediators. This alone is a potentially beneficial anti-inflammatory effect of n-3 fatty acids. However, n-3 fatty acids have a number of other effects that might occur downstream of altered eicosanoid production or are independent of this. For example, they result in suppressed production of pro-inflammatory cytokines and can modulate adhesion molecule expression. These effects occur at the level of altered gene expression.

Authors+Show Affiliations

Institute of Human Nutrition, School of Medicine, University of Southampton, Bassett Crescent East, Southampton SO16 7PX, UK. pcc@soton.ac.uk

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15787620

Citation

Calder, P C.. "Polyunsaturated Fatty Acids and Inflammation." Biochemical Society Transactions, vol. 33, no. Pt 2, 2005, pp. 423-7.
Calder PC. Polyunsaturated fatty acids and inflammation. Biochem Soc Trans. 2005;33(Pt 2):423-7.
Calder, P. C. (2005). Polyunsaturated fatty acids and inflammation. Biochemical Society Transactions, 33(Pt 2), 423-7.
Calder PC. Polyunsaturated Fatty Acids and Inflammation. Biochem Soc Trans. 2005;33(Pt 2):423-7. PubMed PMID: 15787620.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Polyunsaturated fatty acids and inflammation. A1 - Calder,P C, PY - 2005/3/25/pubmed PY - 2005/7/29/medline PY - 2005/3/25/entrez SP - 423 EP - 7 JF - Biochemical Society transactions JO - Biochem. Soc. Trans. VL - 33 IS - Pt 2 N2 - The n-6 polyunsaturated fatty acid, arachidonic acid, is a precursor of prostaglandins, leukotrienes and related compounds that have important roles as mediators and regulators of inflammation. Consuming increased amounts of long chain n-3 polyunsaturated fatty acids (found in oily fish and fish oils) results in a partial replacement of the arachidonic acid in cell membranes by eicosapentaenoic and docosahexaenoic acids. This leads to decreased production of arachidonic acid-derived mediators. This alone is a potentially beneficial anti-inflammatory effect of n-3 fatty acids. However, n-3 fatty acids have a number of other effects that might occur downstream of altered eicosanoid production or are independent of this. For example, they result in suppressed production of pro-inflammatory cytokines and can modulate adhesion molecule expression. These effects occur at the level of altered gene expression. SN - 0300-5127 UR - https://www.unboundmedicine.com/medline/citation/15787620/Polyunsaturated_fatty_acids_and_inflammation_ L2 - https://portlandpress.com/biochemsoctrans/article-lookup/doi/10.1042/BST0330423 DB - PRIME DP - Unbound Medicine ER -