Tags

Type your tag names separated by a space and hit enter

The cutoff value of serum ferritin for the diagnosis of iron deficiency in community-residing older persons.
Ann Hematol 2005; 84(6):358-61AH

Abstract

The serum ferritin assay is the best single blood test for the diagnosis of iron deficiency. Previous studies with elderly anemic patients have suggested that ferritin level less than 45 mug/L is indicative of iron deficiency. The subjects of these studies were hospitalized patients with anemia, however. We thus conducted a prospective study to determine the normal minimum level of serum ferritin of community-dwelling older adults by assessing the ratio of serum transferrin receptor to the log ferritin level (sTfR-F index). We conducted the anemia survey between October and November 2002. A total of 1,254 apparently healthy older adults, aged between 60 and 95 years, from three urban community dwellings participated in the survey. Among these individuals, 156 subjects who were anemic or whose serum ferritin level was less than 100 microg/L were selected. The soluble transferrin receptor assay was performed and the sTfR-F index was calculated. The receiver operating characteristic curve analysis was performed. Based on the data, serum ferritin level of 22 microg/L was selected as the cutoff value for the diagnosis of iron deficiency in community-dwelling older adults. Applying the serum ferritin cutoff of 22 microg/L and the sTfR-F index cutoff of 1.5, the sensitivity of the assay was 89.5% (34 of 38) and the specificity was 89.0% (105 of 118). In conclusion, for the diagnosis of iron deficiency of community-residing older adults, we suggest the serum ferritin cutoff value of 22 microg/L obtained by use of the sTfR-F index. The value is lower than the previous value established for hospitalized and anemic older adults.

Authors+Show Affiliations

Division of Oncology-Hematology, Department of Internal Medicine, Korea University Medical Center, Seoul, South Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15789229

Citation

Choi, Chul Won, et al. "The Cutoff Value of Serum Ferritin for the Diagnosis of Iron Deficiency in Community-residing Older Persons." Annals of Hematology, vol. 84, no. 6, 2005, pp. 358-61.
Choi CW, Cho WR, Park KH, et al. The cutoff value of serum ferritin for the diagnosis of iron deficiency in community-residing older persons. Ann Hematol. 2005;84(6):358-61.
Choi, C. W., Cho, W. R., Park, K. H., Choi, I. K., Seo, J. H., Kim, B. S., ... Lee, J. (2005). The cutoff value of serum ferritin for the diagnosis of iron deficiency in community-residing older persons. Annals of Hematology, 84(6), pp. 358-61.
Choi CW, et al. The Cutoff Value of Serum Ferritin for the Diagnosis of Iron Deficiency in Community-residing Older Persons. Ann Hematol. 2005;84(6):358-61. PubMed PMID: 15789229.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The cutoff value of serum ferritin for the diagnosis of iron deficiency in community-residing older persons. AU - Choi,Chul Won, AU - Cho,Woo Ri, AU - Park,Kyong Hwa, AU - Choi,In Keun, AU - Seo,Jae Hong, AU - Kim,Byung Soo, AU - Shin,Sang Won, AU - Kim,Yeul Hong, AU - Kim,Jun Suk, AU - Lee,Juneyoung, Y1 - 2005/03/24/ PY - 2004/07/06/received PY - 2004/12/30/accepted PY - 2005/3/25/pubmed PY - 2006/11/10/medline PY - 2005/3/25/entrez SP - 358 EP - 61 JF - Annals of hematology JO - Ann. Hematol. VL - 84 IS - 6 N2 - The serum ferritin assay is the best single blood test for the diagnosis of iron deficiency. Previous studies with elderly anemic patients have suggested that ferritin level less than 45 mug/L is indicative of iron deficiency. The subjects of these studies were hospitalized patients with anemia, however. We thus conducted a prospective study to determine the normal minimum level of serum ferritin of community-dwelling older adults by assessing the ratio of serum transferrin receptor to the log ferritin level (sTfR-F index). We conducted the anemia survey between October and November 2002. A total of 1,254 apparently healthy older adults, aged between 60 and 95 years, from three urban community dwellings participated in the survey. Among these individuals, 156 subjects who were anemic or whose serum ferritin level was less than 100 microg/L were selected. The soluble transferrin receptor assay was performed and the sTfR-F index was calculated. The receiver operating characteristic curve analysis was performed. Based on the data, serum ferritin level of 22 microg/L was selected as the cutoff value for the diagnosis of iron deficiency in community-dwelling older adults. Applying the serum ferritin cutoff of 22 microg/L and the sTfR-F index cutoff of 1.5, the sensitivity of the assay was 89.5% (34 of 38) and the specificity was 89.0% (105 of 118). In conclusion, for the diagnosis of iron deficiency of community-residing older adults, we suggest the serum ferritin cutoff value of 22 microg/L obtained by use of the sTfR-F index. The value is lower than the previous value established for hospitalized and anemic older adults. SN - 0939-5555 UR - https://www.unboundmedicine.com/medline/citation/15789229/The_cutoff_value_of_serum_ferritin_for_the_diagnosis_of_iron_deficiency_in_community_residing_older_persons_ L2 - https://dx.doi.org/10.1007/s00277-005-1033-5 DB - PRIME DP - Unbound Medicine ER -