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Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan.
Carcinogenesis 2005; 26(7):1285-90C

Abstract

Folate takes part in two biological pathways involved in DNA methylation and synthesis, and a potential protective influence of this nutrient chemical against carcinogenicity has been recognized in several sites, including the esophagus. Therefore, the functional polymorphisms in genes encoding folate metabolizing enzymes, MTHFR C677T and MTR A2756G, might be suspected of impacting on esophageal cancer risk. We therefore conducted a matched case-control study of 165 esophageal cancer cases and 495 non-cancer controls to clarify associations among folate intake, MTHFR C677T and MTR A2756G polymorphisms, and esophageal cancer risk. Gene-environment interactions between the two polymorphisms, and drinking and smoking were also evaluated. Folate consumption and MTHFR 677TT were associated with a non-significant tendency for decreased risk while the MTR genotypes did not show any links in themselves; further, when analysis was limited to heavy drinkers, the MTHFR TT genotype significantly decreased esophageal cancer risk [odds ratio (OR) = 0.27, 95% confidence interval (CI), 0.09-0.76]. The OR for the gene-environment interaction between heavy drinking and the 677TT genotype in the case-only design was 0.31 (95% CI, 0.10-0.94), indicating risk with heavy drinking to be 69% decreased in individuals harboring the 677TT genotype. We failed to find any significant interaction between either of the polymorphisms and smoking.

Authors+Show Affiliations

Department of Epidemiology, Huaxi Public Health School, Sichuan University, Chengdu 610041, China.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15790587

Citation

Yang, Chun-Xia, et al. "Gene-environment Interactions Between Alcohol Drinking and the MTHFR C677T Polymorphism Impact On Esophageal Cancer Risk: Results of a Case-control Study in Japan." Carcinogenesis, vol. 26, no. 7, 2005, pp. 1285-90.
Yang CX, Matsuo K, Ito H, et al. Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan. Carcinogenesis. 2005;26(7):1285-90.
Yang, C. X., Matsuo, K., Ito, H., Shinoda, M., Hatooka, S., Hirose, K., ... Tajima, K. (2005). Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan. Carcinogenesis, 26(7), pp. 1285-90.
Yang CX, et al. Gene-environment Interactions Between Alcohol Drinking and the MTHFR C677T Polymorphism Impact On Esophageal Cancer Risk: Results of a Case-control Study in Japan. Carcinogenesis. 2005;26(7):1285-90. PubMed PMID: 15790587.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gene-environment interactions between alcohol drinking and the MTHFR C677T polymorphism impact on esophageal cancer risk: results of a case-control study in Japan. AU - Yang,Chun-Xia, AU - Matsuo,Keitaro, AU - Ito,Hidemi, AU - Shinoda,Masayuki, AU - Hatooka,Shunzo, AU - Hirose,Kaoru, AU - Wakai,Kenji, AU - Saito,Toshiko, AU - Suzuki,Takeshi, AU - Maeda,Takako, AU - Tajima,Kazuo, Y1 - 2005/03/24/ PY - 2005/3/26/pubmed PY - 2005/7/30/medline PY - 2005/3/26/entrez SP - 1285 EP - 90 JF - Carcinogenesis JO - Carcinogenesis VL - 26 IS - 7 N2 - Folate takes part in two biological pathways involved in DNA methylation and synthesis, and a potential protective influence of this nutrient chemical against carcinogenicity has been recognized in several sites, including the esophagus. Therefore, the functional polymorphisms in genes encoding folate metabolizing enzymes, MTHFR C677T and MTR A2756G, might be suspected of impacting on esophageal cancer risk. We therefore conducted a matched case-control study of 165 esophageal cancer cases and 495 non-cancer controls to clarify associations among folate intake, MTHFR C677T and MTR A2756G polymorphisms, and esophageal cancer risk. Gene-environment interactions between the two polymorphisms, and drinking and smoking were also evaluated. Folate consumption and MTHFR 677TT were associated with a non-significant tendency for decreased risk while the MTR genotypes did not show any links in themselves; further, when analysis was limited to heavy drinkers, the MTHFR TT genotype significantly decreased esophageal cancer risk [odds ratio (OR) = 0.27, 95% confidence interval (CI), 0.09-0.76]. The OR for the gene-environment interaction between heavy drinking and the 677TT genotype in the case-only design was 0.31 (95% CI, 0.10-0.94), indicating risk with heavy drinking to be 69% decreased in individuals harboring the 677TT genotype. We failed to find any significant interaction between either of the polymorphisms and smoking. SN - 0143-3334 UR - https://www.unboundmedicine.com/medline/citation/15790587/Gene_environment_interactions_between_alcohol_drinking_and_the_MTHFR_C677T_polymorphism_impact_on_esophageal_cancer_risk:_results_of_a_case_control_study_in_Japan_ L2 - https://academic.oup.com/carcin/article-lookup/doi/10.1093/carcin/bgi076 DB - PRIME DP - Unbound Medicine ER -