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Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial.
Hum Reprod 2005; 20(6):1521-8HR

Abstract

BACKGROUND

The aim of the current study was to assess the effects of B-group vitamins and folic acid administration on serum levels of homocysteine (Hcy) in patients with polycystic ovarian syndrome (PCOS) on short-term metformin treatment.

METHODS

Patients were randomly assigned to one of three treatment groups. Group 1 patients (n = 20) received metformin (850 mg twice daily); group 2 patients (n = 20) received metformin (850 mg twice daily) and B-group vitamins (vitamin B1, 250 mg; vitamin B6, 250 mg; vitamin B12, 1000 microg twice daily); and group 3 patients (n = 20) received metformin (850 mg twice daily) and folic acid (174 microg twice daily). In all groups, lipid profiles and plasma total Hcy, vitamin B12, folic acid and glucose levels were recorded at baseline and at 3 months.

RESULTS

A 26.5% increase in Hcy levels was seen after 12 weeks of metformin therapy, while 21.17 and 8.33% decreases in Hcy levels were detected when B-group vitamins or folic acid plus metformin were given respectively. There were no statistically significant differences recorded in insulin sensitivity using homeostasis model assessment in the three groups.

CONCLUSION

These findings suggest that B-group vitamins and folic acid administration counteract the Hcy-increasing effect seen with metformin therapy.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Baskent University Faculty of Medicine, Turkey. esrabulgan1972@mynet.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15790610

Citation

Kilicdag, Esra Bulgan, et al. "Administration of B-group Vitamins Reduces Circulating Homocysteine in Polycystic Ovarian Syndrome Patients Treated With Metformin: a Randomized Trial." Human Reproduction (Oxford, England), vol. 20, no. 6, 2005, pp. 1521-8.
Kilicdag EB, Bagis T, Tarim E, et al. Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial. Hum Reprod. 2005;20(6):1521-8.
Kilicdag, E. B., Bagis, T., Tarim, E., Aslan, E., Erkanli, S., Simsek, E., ... Kuscu, E. (2005). Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial. Human Reproduction (Oxford, England), 20(6), pp. 1521-8.
Kilicdag EB, et al. Administration of B-group Vitamins Reduces Circulating Homocysteine in Polycystic Ovarian Syndrome Patients Treated With Metformin: a Randomized Trial. Hum Reprod. 2005;20(6):1521-8. PubMed PMID: 15790610.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Administration of B-group vitamins reduces circulating homocysteine in polycystic ovarian syndrome patients treated with metformin: a randomized trial. AU - Kilicdag,Esra Bulgan, AU - Bagis,Tayfun, AU - Tarim,Ebru, AU - Aslan,Erdogan, AU - Erkanli,Serkan, AU - Simsek,Erhan, AU - Haydardedeoglu,Bulent, AU - Kuscu,Esra, Y1 - 2005/03/24/ PY - 2005/3/26/pubmed PY - 2005/9/30/medline PY - 2005/3/26/entrez SP - 1521 EP - 8 JF - Human reproduction (Oxford, England) JO - Hum. Reprod. VL - 20 IS - 6 N2 - BACKGROUND: The aim of the current study was to assess the effects of B-group vitamins and folic acid administration on serum levels of homocysteine (Hcy) in patients with polycystic ovarian syndrome (PCOS) on short-term metformin treatment. METHODS: Patients were randomly assigned to one of three treatment groups. Group 1 patients (n = 20) received metformin (850 mg twice daily); group 2 patients (n = 20) received metformin (850 mg twice daily) and B-group vitamins (vitamin B1, 250 mg; vitamin B6, 250 mg; vitamin B12, 1000 microg twice daily); and group 3 patients (n = 20) received metformin (850 mg twice daily) and folic acid (174 microg twice daily). In all groups, lipid profiles and plasma total Hcy, vitamin B12, folic acid and glucose levels were recorded at baseline and at 3 months. RESULTS: A 26.5% increase in Hcy levels was seen after 12 weeks of metformin therapy, while 21.17 and 8.33% decreases in Hcy levels were detected when B-group vitamins or folic acid plus metformin were given respectively. There were no statistically significant differences recorded in insulin sensitivity using homeostasis model assessment in the three groups. CONCLUSION: These findings suggest that B-group vitamins and folic acid administration counteract the Hcy-increasing effect seen with metformin therapy. SN - 0268-1161 UR - https://www.unboundmedicine.com/medline/citation/15790610/Administration_of_B_group_vitamins_reduces_circulating_homocysteine_in_polycystic_ovarian_syndrome_patients_treated_with_metformin:_a_randomized_trial_ L2 - https://academic.oup.com/humrep/article-lookup/doi/10.1093/humrep/deh825 DB - PRIME DP - Unbound Medicine ER -