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Retinal vessel diameters and incident open-angle glaucoma and optic disc changes: the Rotterdam study.
Invest Ophthalmol Vis Sci 2005; 46(4):1182-7IO

Abstract

PURPOSE

It remains unclear whether reduced retinal blood flow and smaller arterioles, reported to exist in patients with open-angle glaucoma (OAG), are a cause or a consequence of ganglion cell loss. We examined whether baseline retinal vessel diameters were related to incident (i)OAG or incident optic disc changes in a population-based sample.

METHODS

In the prospective population-based Rotterdam Study, baseline diameters of retinal arterioles and venules (1990-1993) were measured in digitized images of 3469 persons (aged 55 years and older) at risk for OAG. The follow-up examinations took place from 1997 to 1999. iOAG was based on the presence of incident glaucomatous visual field loss and/or incident glaucomatous optic neuropathy. Changes in neuroretinal rim, cup area, or vertical cup-to-disc ratio were calculated with a semiautomated image analyzer in 2782 persons.

RESULTS

After a mean follow-up time of 6.5 years, 74 participants had iOAG. At baseline, the mean arteriolar diameter was 147.5 +/- 14.2 microm (SD) and the venular, 222.9 +/- 20.0 microm. Neither arteriolar diameters (odds ratio [OR] per SD decrease: 0.82; 95% confidence interval [CI]: 0.66-1.03) nor venular ones (OR per SD increase: 1.20; 95% CI: 0.95-1.53) were significantly related to iOAG. Baseline retinal vessel diameters did not predict changes in the optic disc. Additional adjustment for cardiovascular risk factors did not alter these results.

CONCLUSIONS

The data show that baseline retinal vessel diameters did not influence the risk of iOAG or incident optic disc changes. These data provide no evidence for a retinal vascular role in the pathogenesis of OAG.

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  • Publisher Full Text

    • Authors+Show Affiliations

    Ikram MK
    Department of Epidemiology and Biostatistics, Erasmus Medical Center, Rotterdam, The Netherlands.
    de Voogd S
    No affiliation info available
    Wolfs RC
    No affiliation info available
    Hofman A
    No affiliation info available
    Breteler MM
    No affiliation info available
    Hubbard LD
    No affiliation info available
    de Jong PT
    No affiliation info available

    MeSH

    AgedBlood PressureFemaleGlaucoma, Open-AngleHumansIntraocular PressureMaleMiddle AgedOptic DiskOptic Nerve DiseasesProspective StudiesRetinal VesselsRisk Factors

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15790877

    Citation

    Ikram, M Kamran, et al. "Retinal Vessel Diameters and Incident Open-angle Glaucoma and Optic Disc Changes: the Rotterdam Study." Investigative Ophthalmology & Visual Science, vol. 46, no. 4, 2005, pp. 1182-7.
    Ikram MK, de Voogd S, Wolfs RC, et al. Retinal vessel diameters and incident open-angle glaucoma and optic disc changes: the Rotterdam study. Invest Ophthalmol Vis Sci. 2005;46(4):1182-7.
    Ikram, M. K., de Voogd, S., Wolfs, R. C., Hofman, A., Breteler, M. M., Hubbard, L. D., & de Jong, P. T. (2005). Retinal vessel diameters and incident open-angle glaucoma and optic disc changes: the Rotterdam study. Investigative Ophthalmology & Visual Science, 46(4), pp. 1182-7.
    Ikram MK, et al. Retinal Vessel Diameters and Incident Open-angle Glaucoma and Optic Disc Changes: the Rotterdam Study. Invest Ophthalmol Vis Sci. 2005;46(4):1182-7. PubMed PMID: 15790877.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Retinal vessel diameters and incident open-angle glaucoma and optic disc changes: the Rotterdam study. AU - Ikram,M Kamran, AU - de Voogd,Simone, AU - Wolfs,Roger C W, AU - Hofman,Albert, AU - Breteler,Monique M B, AU - Hubbard,Larry D, AU - de Jong,Paulus T V M, PY - 2005/3/26/pubmed PY - 2005/5/13/medline PY - 2005/3/26/entrez SP - 1182 EP - 7 JF - Investigative ophthalmology & visual science JO - Invest. Ophthalmol. Vis. Sci. VL - 46 IS - 4 N2 - PURPOSE: It remains unclear whether reduced retinal blood flow and smaller arterioles, reported to exist in patients with open-angle glaucoma (OAG), are a cause or a consequence of ganglion cell loss. We examined whether baseline retinal vessel diameters were related to incident (i)OAG or incident optic disc changes in a population-based sample. METHODS: In the prospective population-based Rotterdam Study, baseline diameters of retinal arterioles and venules (1990-1993) were measured in digitized images of 3469 persons (aged 55 years and older) at risk for OAG. The follow-up examinations took place from 1997 to 1999. iOAG was based on the presence of incident glaucomatous visual field loss and/or incident glaucomatous optic neuropathy. Changes in neuroretinal rim, cup area, or vertical cup-to-disc ratio were calculated with a semiautomated image analyzer in 2782 persons. RESULTS: After a mean follow-up time of 6.5 years, 74 participants had iOAG. At baseline, the mean arteriolar diameter was 147.5 +/- 14.2 microm (SD) and the venular, 222.9 +/- 20.0 microm. Neither arteriolar diameters (odds ratio [OR] per SD decrease: 0.82; 95% confidence interval [CI]: 0.66-1.03) nor venular ones (OR per SD increase: 1.20; 95% CI: 0.95-1.53) were significantly related to iOAG. Baseline retinal vessel diameters did not predict changes in the optic disc. Additional adjustment for cardiovascular risk factors did not alter these results. CONCLUSIONS: The data show that baseline retinal vessel diameters did not influence the risk of iOAG or incident optic disc changes. These data provide no evidence for a retinal vascular role in the pathogenesis of OAG. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/15790877/Retinal_vessel_diameters_and_incident_open_angle_glaucoma_and_optic_disc_changes:_the_Rotterdam_study_ L2 - http://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.04-1459 DB - PRIME DP - Unbound Medicine ER -