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Central corneal thickness correlated with glaucoma damage and rate of progression.
Invest Ophthalmol Vis Sci. 2005 Apr; 46(4):1269-74.IO

Abstract

PURPOSE

To evaluate whether the amount of glaucomatous optic nerve damage at presentation of the patient and the rate of progression of glaucoma during follow-up are related to central corneal thickness.

METHODS

The prospective observational clinical study included 861 eyes of 454 white subjects (239 normal eyes of 121 subjects, 250 ocular hypertensive eyes of 118 patients, 372 eyes of 215 patients with chronic open-angle glaucoma). For 567 eyes (304 patients) with ocular hypertension or chronic open-angle glaucoma, follow-up examinations were performed, with a mean follow-up time of 62.7 +/- 33.2 months (median, 60.8; range, 6.2-124.9). All patients underwent qualitative and morphometric evaluation of color stereo optic disc photographs and white-on-white visual field examination. Central corneal thickness was measured by corneal pachymetry.

RESULTS

Central corneal thickness correlated significantly (P < 0.001) and positively with the area of the neuroretinal rim and negatively with the loss of visual field. Development or progression of glaucomatous visual field defects detected in 119 (21.0%) eyes was statistically independent of central corneal thickness, in univariate (P = 0.99) and multivariate Cox regression analyses (P = 0.19).

CONCLUSIONS

At the time of patient referral, the amount of glaucomatous optic nerve damage correlated significantly with a thin central cornea. Progression of glaucomatous optic nerve neuropathy was independent of central corneal thickness, suggesting that central corneal thickness may not play a major role in the pathogenesis of progressive glaucomatous optic nerve damage.

Authors+Show Affiliations

Department of Ophthalmology and Eye Hospital, University Erlangen-Nürnberg, Erlangen, Germany. jost.jonas@augen.ma.uni-heidelberg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15790889

Citation

Jonas, Jost B., et al. "Central Corneal Thickness Correlated With Glaucoma Damage and Rate of Progression." Investigative Ophthalmology & Visual Science, vol. 46, no. 4, 2005, pp. 1269-74.
Jonas JB, Stroux A, Velten I, et al. Central corneal thickness correlated with glaucoma damage and rate of progression. Invest Ophthalmol Vis Sci. 2005;46(4):1269-74.
Jonas, J. B., Stroux, A., Velten, I., Juenemann, A., Martus, P., & Budde, W. M. (2005). Central corneal thickness correlated with glaucoma damage and rate of progression. Investigative Ophthalmology & Visual Science, 46(4), 1269-74.
Jonas JB, et al. Central Corneal Thickness Correlated With Glaucoma Damage and Rate of Progression. Invest Ophthalmol Vis Sci. 2005;46(4):1269-74. PubMed PMID: 15790889.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Central corneal thickness correlated with glaucoma damage and rate of progression. AU - Jonas,Jost B, AU - Stroux,Andrea, AU - Velten,Isabel, AU - Juenemann,Anselm, AU - Martus,Peter, AU - Budde,Wido M, PY - 2005/3/26/pubmed PY - 2005/5/13/medline PY - 2005/3/26/entrez SP - 1269 EP - 74 JF - Investigative ophthalmology & visual science JO - Invest Ophthalmol Vis Sci VL - 46 IS - 4 N2 - PURPOSE: To evaluate whether the amount of glaucomatous optic nerve damage at presentation of the patient and the rate of progression of glaucoma during follow-up are related to central corneal thickness. METHODS: The prospective observational clinical study included 861 eyes of 454 white subjects (239 normal eyes of 121 subjects, 250 ocular hypertensive eyes of 118 patients, 372 eyes of 215 patients with chronic open-angle glaucoma). For 567 eyes (304 patients) with ocular hypertension or chronic open-angle glaucoma, follow-up examinations were performed, with a mean follow-up time of 62.7 +/- 33.2 months (median, 60.8; range, 6.2-124.9). All patients underwent qualitative and morphometric evaluation of color stereo optic disc photographs and white-on-white visual field examination. Central corneal thickness was measured by corneal pachymetry. RESULTS: Central corneal thickness correlated significantly (P < 0.001) and positively with the area of the neuroretinal rim and negatively with the loss of visual field. Development or progression of glaucomatous visual field defects detected in 119 (21.0%) eyes was statistically independent of central corneal thickness, in univariate (P = 0.99) and multivariate Cox regression analyses (P = 0.19). CONCLUSIONS: At the time of patient referral, the amount of glaucomatous optic nerve damage correlated significantly with a thin central cornea. Progression of glaucomatous optic nerve neuropathy was independent of central corneal thickness, suggesting that central corneal thickness may not play a major role in the pathogenesis of progressive glaucomatous optic nerve damage. SN - 0146-0404 UR - https://www.unboundmedicine.com/medline/citation/15790889/Central_corneal_thickness_correlated_with_glaucoma_damage_and_rate_of_progression_ L2 - https://iovs.arvojournals.org/article.aspx?doi=10.1167/iovs.04-0265 DB - PRIME DP - Unbound Medicine ER -