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Effects of montelukast on airway narrowing from eucapnic voluntary hyperventilation and cold air exercise.
Br J Sports Med. 2005 Apr; 39(4):232-6.BJ

Abstract

BACKGROUND

Exercise induced bronchoconstriction (EIB) is common in elite athletes. Eucapnic voluntary hyperventilation (EVH) is a laboratory test recommended for the identification of EIB in athletes, secondary to a field exercise challenge. Montelukast attenuates EIB, but its protective effect against airway narrowing from EVH has not been investigated.

OBJECTIVE

To examine the effectiveness of montelukast after exercise and after EVH.

METHODS

A randomised, placebo controlled, double blind, crossover study was performed with 11 physically active EIB positive subjects (eight men, three women; mean (SD) age 22.8 (6.8) years). Six hours before each of the following challenges 10 mg montelukast or placebo was ingested: (a) a six minute, cold air (-3 degrees C) maximal effort work accumulation cycle ergometer exercise; (b) EVH, breathing 5% CO(2) compressed air at 85% maximal voluntary ventilation for six minutes. Spirometry was performed before and 5, 10, and 15 minutes after the challenge. At least 48 hours was observed between challenges.

RESULTS

No differences in forced expiratory volume in one second (FEV(1)) were found after the two challenges. Exercise and EVH resulted in falls in FEV(1) of 22.4 (18.0) and 25.6 (16.8) respectively. Falls in FEV(1) after montelukast were less than after placebo (10.6 (10.6) and 14.3 (11.3) after exercise and EVH respectively; p<0.05). Montelukast provided protection against bronchoconstriction (59% and 53%; p<0.05) for eight exercising subjects and 10 EVH subjects; no protection was afforded for three exercising and one EVH challenged subject.

CONCLUSIONS

Both exercise and EVH were potent stimuli of airway narrowing. A single dose of montelukast provided reasonable protection in attenuating bronchoconstriction from either exercise or EVH. The similar protection by montelukast suggests that EVH is a suitable laboratory surrogate for EIB evaluation.

Authors+Show Affiliations

Human Performance Laboratory, Marywood University, 2300 Adams Avenue, Scranton, PA 18509, USA. rundell@marywood.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15793094

Citation

Rundell, K W., et al. "Effects of Montelukast On Airway Narrowing From Eucapnic Voluntary Hyperventilation and Cold Air Exercise." British Journal of Sports Medicine, vol. 39, no. 4, 2005, pp. 232-6.
Rundell KW, Spiering BA, Baumann JM, et al. Effects of montelukast on airway narrowing from eucapnic voluntary hyperventilation and cold air exercise. Br J Sports Med. 2005;39(4):232-6.
Rundell, K. W., Spiering, B. A., Baumann, J. M., & Evans, T. M. (2005). Effects of montelukast on airway narrowing from eucapnic voluntary hyperventilation and cold air exercise. British Journal of Sports Medicine, 39(4), 232-6.
Rundell KW, et al. Effects of Montelukast On Airway Narrowing From Eucapnic Voluntary Hyperventilation and Cold Air Exercise. Br J Sports Med. 2005;39(4):232-6. PubMed PMID: 15793094.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of montelukast on airway narrowing from eucapnic voluntary hyperventilation and cold air exercise. AU - Rundell,K W, AU - Spiering,B A, AU - Baumann,J M, AU - Evans,T M, PY - 2005/3/29/pubmed PY - 2005/6/9/medline PY - 2005/3/29/entrez SP - 232 EP - 6 JF - British journal of sports medicine JO - Br J Sports Med VL - 39 IS - 4 N2 - BACKGROUND: Exercise induced bronchoconstriction (EIB) is common in elite athletes. Eucapnic voluntary hyperventilation (EVH) is a laboratory test recommended for the identification of EIB in athletes, secondary to a field exercise challenge. Montelukast attenuates EIB, but its protective effect against airway narrowing from EVH has not been investigated. OBJECTIVE: To examine the effectiveness of montelukast after exercise and after EVH. METHODS: A randomised, placebo controlled, double blind, crossover study was performed with 11 physically active EIB positive subjects (eight men, three women; mean (SD) age 22.8 (6.8) years). Six hours before each of the following challenges 10 mg montelukast or placebo was ingested: (a) a six minute, cold air (-3 degrees C) maximal effort work accumulation cycle ergometer exercise; (b) EVH, breathing 5% CO(2) compressed air at 85% maximal voluntary ventilation for six minutes. Spirometry was performed before and 5, 10, and 15 minutes after the challenge. At least 48 hours was observed between challenges. RESULTS: No differences in forced expiratory volume in one second (FEV(1)) were found after the two challenges. Exercise and EVH resulted in falls in FEV(1) of 22.4 (18.0) and 25.6 (16.8) respectively. Falls in FEV(1) after montelukast were less than after placebo (10.6 (10.6) and 14.3 (11.3) after exercise and EVH respectively; p<0.05). Montelukast provided protection against bronchoconstriction (59% and 53%; p<0.05) for eight exercising subjects and 10 EVH subjects; no protection was afforded for three exercising and one EVH challenged subject. CONCLUSIONS: Both exercise and EVH were potent stimuli of airway narrowing. A single dose of montelukast provided reasonable protection in attenuating bronchoconstriction from either exercise or EVH. The similar protection by montelukast suggests that EVH is a suitable laboratory surrogate for EIB evaluation. SN - 1473-0480 UR - https://www.unboundmedicine.com/medline/citation/15793094/Effects_of_montelukast_on_airway_narrowing_from_eucapnic_voluntary_hyperventilation_and_cold_air_exercise_ L2 - https://bjsm.bmj.com/lookup/pmidlookup?view=long&amp;pmid=15793094 DB - PRIME DP - Unbound Medicine ER -