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Curative resection of T1 colorectal carcinoma: risk of lymph node metastasis and long-term prognosis.
Dis Colon Rectum. 2005 Jun; 48(6):1182-92.DC

Abstract

PURPOSE

The features of T1 colorectal adenocarcinoma and the risk determination of lymph node metastasis were reviewed. Prognostic factors were assessed to verify whether the risk of lymph node metastasis would influence the long-term prognosis.

METHODS

Patients undergoing curative resection of T1 colorectal adenocarcinoma at the Taipei Veterans General Hospital from December 1969 to August 2002 were retrospectively studied. Patients with synchronous colorectal cancer, distant metastasis, familiar adenomatous polyposis, or inflammatory bowel disease were excluded. The associations between lymph node metastasis and clinicopathologic variables were evaluated univariately using chi-squared test, Fisher's exact test, or Student's t -test, and multivariately using logistic regression. Univariate analysis by the log-rank test and multivariate analysis by Cox regression hazards model determined the factors influencing the overall survival.

RESULTS

A total of 159 patients were included. Sixteen patients (10.1 percent) had lymph node metastasis. The risk of lymph node metastasis included histologic grade (P = 0.005), lymphatic vessel invasion (P = 0.023), inflammation around cancer (P = 0.049), and budding at the invasive front of tumor (P = 0.022). Age (P = 0.001) and number of total sampling lymph nodes (P < 0.0001) were found to be the factors influencing the overall survival.

CONCLUSIONS

Variables that predict lymph node metastasis in surgically resected T1 colorectal carcinoma may not impact the long-term prognosis.

Authors+Show Affiliations

Wang HS
Division of Colon and Rectal Surgery, Department of Surgery, Taipei Veterans General Hospital, Taipei, Taiwan, Republic of China.
Liang WY
No affiliation info available
Lin TC
No affiliation info available
Chen WS
No affiliation info available
Jiang JK
No affiliation info available
Yang SH
No affiliation info available
Chang SC
No affiliation info available
Lin JK
No affiliation info available

MeSH

AdenocarcinomaAdolescentAdultAgedAged, 80 and overColonic NeoplasmsFemaleFollow-Up StudiesHumansLymphatic MetastasisMaleMiddle AgedNeoplasm StagingPrognosisRectal NeoplasmsRetrospective StudiesRisk FactorsSurvival Rate

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15793641

Citation

Wang, Huann-Sheng, et al. "Curative Resection of T1 Colorectal Carcinoma: Risk of Lymph Node Metastasis and Long-term Prognosis." Diseases of the Colon and Rectum, vol. 48, no. 6, 2005, pp. 1182-92.
Wang HS, Liang WY, Lin TC, et al. Curative resection of T1 colorectal carcinoma: risk of lymph node metastasis and long-term prognosis. Dis Colon Rectum. 2005;48(6):1182-92.
Wang, H. S., Liang, W. Y., Lin, T. C., Chen, W. S., Jiang, J. K., Yang, S. H., Chang, S. C., & Lin, J. K. (2005). Curative resection of T1 colorectal carcinoma: risk of lymph node metastasis and long-term prognosis. Diseases of the Colon and Rectum, 48(6), 1182-92.
Wang HS, et al. Curative Resection of T1 Colorectal Carcinoma: Risk of Lymph Node Metastasis and Long-term Prognosis. Dis Colon Rectum. 2005;48(6):1182-92. PubMed PMID: 15793641.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Curative resection of T1 colorectal carcinoma: risk of lymph node metastasis and long-term prognosis. AU - Wang,Huann-Sheng, AU - Liang,Wen-Yih, AU - Lin,Tzu-Chen, AU - Chen,Wei-Shone, AU - Jiang,Jeng-Kae, AU - Yang,Shung-Haur, AU - Chang,Shih-Ching, AU - Lin,Jen-Kou, PY - 2005/3/29/pubmed PY - 2005/7/13/medline PY - 2005/3/29/entrez SP - 1182 EP - 92 JF - Diseases of the colon and rectum JO - Dis Colon Rectum VL - 48 IS - 6 N2 - PURPOSE: The features of T1 colorectal adenocarcinoma and the risk determination of lymph node metastasis were reviewed. Prognostic factors were assessed to verify whether the risk of lymph node metastasis would influence the long-term prognosis. METHODS: Patients undergoing curative resection of T1 colorectal adenocarcinoma at the Taipei Veterans General Hospital from December 1969 to August 2002 were retrospectively studied. Patients with synchronous colorectal cancer, distant metastasis, familiar adenomatous polyposis, or inflammatory bowel disease were excluded. The associations between lymph node metastasis and clinicopathologic variables were evaluated univariately using chi-squared test, Fisher's exact test, or Student's t -test, and multivariately using logistic regression. Univariate analysis by the log-rank test and multivariate analysis by Cox regression hazards model determined the factors influencing the overall survival. RESULTS: A total of 159 patients were included. Sixteen patients (10.1 percent) had lymph node metastasis. The risk of lymph node metastasis included histologic grade (P = 0.005), lymphatic vessel invasion (P = 0.023), inflammation around cancer (P = 0.049), and budding at the invasive front of tumor (P = 0.022). Age (P = 0.001) and number of total sampling lymph nodes (P < 0.0001) were found to be the factors influencing the overall survival. CONCLUSIONS: Variables that predict lymph node metastasis in surgically resected T1 colorectal carcinoma may not impact the long-term prognosis. SN - 0012-3706 UR - https://www.unboundmedicine.com/medline/citation/15793641/Curative_resection_of_T1_colorectal_carcinoma:_risk_of_lymph_node_metastasis_and_long_term_prognosis_ DB - PRIME DP - Unbound Medicine ER -