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Apolipoprotein A-I, A-II, B, C-II, and C-III in children with insulin-dependent diabetes mellitus.
Pediatrics 1992; 89(5 Pt 1):936-41Ped

Abstract

This study was conducted to determine whether changes in the levels of plasma apolipoproteins (apo) A-I, A-II, B, C-II, and C-III, along with cholesterol and triglycerides, could provide additional information on these parameters in relation to the control of glycemia. Plasma and lipoprotein lipids and apolipoprotein levels were measured in 123 insulin-dependent diabetic children (4- to 12-years-old), classified into good, fair, and poor diabetic control based on HbA1c and fructosamine levels, and in 62 comparable healthy controls. Total cholesterol, very low density lipoprotein cholesterol, and low density lipoprotein cholesterol, as well as total triglycerides, very low density lipoprotein, low density lipoprotein, and high density lipoprotein (HDL) triglycerides, and apo B and apo C-III were increased significantly in children with fair and poor diabetic control. While in diabetic children with good control, only very low density lipoprotein cholesterol was elevated significantly compared with healthy control subjects. Conversely, the levels of cholesterol in HDL, HDL2, HDL3, and apo A-I were decreased significantly in the three diabetic groups, but apo A-II and apo C-II did not change. We conclude that in children with insulin-dependent diabetes mellitus, abnormalities in plasma lipid, lipoprotein, and apolipoprotein levels occur, the extent of which depends on the degree (extent) of glycemic control (the poorer the control the more substantial the abnormality). We suggest that measurement of apo C-III level along with apo B and apo A-I in these patients may be a sensitive indicator to alterations in glycemic control.

Authors+Show Affiliations

Department of Medicine, Faculty of Medicine, Kuwait.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

1579407

Citation

al Muhtaseb, N, et al. "Apolipoprotein A-I, A-II, B, C-II, and C-III in Children With Insulin-dependent Diabetes Mellitus." Pediatrics, vol. 89, no. 5 Pt 1, 1992, pp. 936-41.
al Muhtaseb N, al Yousuf A, Bajaj JS. Apolipoprotein A-I, A-II, B, C-II, and C-III in children with insulin-dependent diabetes mellitus. Pediatrics. 1992;89(5 Pt 1):936-41.
al Muhtaseb, N., al Yousuf, A., & Bajaj, J. S. (1992). Apolipoprotein A-I, A-II, B, C-II, and C-III in children with insulin-dependent diabetes mellitus. Pediatrics, 89(5 Pt 1), pp. 936-41.
al Muhtaseb N, al Yousuf A, Bajaj JS. Apolipoprotein A-I, A-II, B, C-II, and C-III in Children With Insulin-dependent Diabetes Mellitus. Pediatrics. 1992;89(5 Pt 1):936-41. PubMed PMID: 1579407.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein A-I, A-II, B, C-II, and C-III in children with insulin-dependent diabetes mellitus. AU - al Muhtaseb,N, AU - al Yousuf,A, AU - Bajaj,J S, PY - 1992/5/1/pubmed PY - 1992/5/1/medline PY - 1992/5/1/entrez SP - 936 EP - 41 JF - Pediatrics JO - Pediatrics VL - 89 IS - 5 Pt 1 N2 - This study was conducted to determine whether changes in the levels of plasma apolipoproteins (apo) A-I, A-II, B, C-II, and C-III, along with cholesterol and triglycerides, could provide additional information on these parameters in relation to the control of glycemia. Plasma and lipoprotein lipids and apolipoprotein levels were measured in 123 insulin-dependent diabetic children (4- to 12-years-old), classified into good, fair, and poor diabetic control based on HbA1c and fructosamine levels, and in 62 comparable healthy controls. Total cholesterol, very low density lipoprotein cholesterol, and low density lipoprotein cholesterol, as well as total triglycerides, very low density lipoprotein, low density lipoprotein, and high density lipoprotein (HDL) triglycerides, and apo B and apo C-III were increased significantly in children with fair and poor diabetic control. While in diabetic children with good control, only very low density lipoprotein cholesterol was elevated significantly compared with healthy control subjects. Conversely, the levels of cholesterol in HDL, HDL2, HDL3, and apo A-I were decreased significantly in the three diabetic groups, but apo A-II and apo C-II did not change. We conclude that in children with insulin-dependent diabetes mellitus, abnormalities in plasma lipid, lipoprotein, and apolipoprotein levels occur, the extent of which depends on the degree (extent) of glycemic control (the poorer the control the more substantial the abnormality). We suggest that measurement of apo C-III level along with apo B and apo A-I in these patients may be a sensitive indicator to alterations in glycemic control. SN - 0031-4005 UR - https://www.unboundmedicine.com/medline/citation/1579407/Apolipoprotein_A_I_A_II_B_C_II_and_C_III_in_children_with_insulin_dependent_diabetes_mellitus_ L2 - http://pediatrics.aappublications.org/cgi/pmidlookup?view=long&pmid=1579407 DB - PRIME DP - Unbound Medicine ER -