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[Autoimmune urticaria. Treatment with methotrexate].
Rev Alerg Mex. 2004 Sep-Oct; 51(5):167-72.RA

Abstract

BACKGROUND

It has been established that 27-50% of patients with idiopathic chronic urticaria have antibodies directed against the alpha chain of the high-affinity IgE receptor, which are indirectly detected by cutaneous tests with autoserum. Thus, an autoimmune urticaria diagnosis can be settled.

OBJECTIVE

To prove methotrexate's efficiency in patients with autoimmune urticaria.

MATERIAL AND METHODS

Seven patients took part in the study. A series of tests was performed in order to rule out any possible infectious, metabolic, or physical etiology. Initial treatment with methotrexate with doses of 2.5 mg every 12 hours, two days a week was provided. In case there were no toxicity data, doses would increase to three days a week for a 6-week period.

RESULTS

Statistically significant improvement was observed in the itching, as well as the presence of spots, repercussion on daily activities, sleep disorders. There was no statistical difference regarding the extension of the lesions and the presence of angioedema. Adverse effects were not significant.

CONCLUSION

We conclude that methotrexate is effective in the treatment of autoimmune urticaria.

Authors+Show Affiliations

Montero Mora P
Servicio de alergia e inmunologia clinica, Hospital de Especialidades, Centro Médico Nacional Siglo XXI, IMSS, México, DF.
González Pérez Mdel C
No affiliation info available
Almeida Arvizu V
No affiliation info available
Matta Campos JJ
No affiliation info available

MeSH

AcetatesAntibody SpecificityAutoantibodiesAutoantigensAutoimmune DiseasesCyclopropanesDrug SynergismDrug Therapy, CombinationHistamine H1 AntagonistsHumansHydroxyzineImmunosuppressive AgentsLeukotriene AntagonistsLoratadineMethotrexateQuinolinesReceptors, IgESulfidesTreatment OutcomeUrticaria

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

spa

PubMed ID

15794405

Citation

Montero Mora, Patricia, et al. "[Autoimmune Urticaria. Treatment With Methotrexate]." Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993), vol. 51, no. 5, 2004, pp. 167-72.
Montero Mora P, González Pérez Mdel C, Almeida Arvizu V, et al. [Autoimmune urticaria. Treatment with methotrexate]. Rev Alerg Mex. 2004;51(5):167-72.
Montero Mora, P., González Pérez, M. d. e. l. . C., Almeida Arvizu, V., & Matta Campos, J. J. (2004). [Autoimmune urticaria. Treatment with methotrexate]. Revista Alergia Mexico (Tecamachalco, Puebla, Mexico : 1993), 51(5), 167-72.
Montero Mora P, et al. [Autoimmune Urticaria. Treatment With Methotrexate]. Rev Alerg Mex. 2004 Sep-Oct;51(5):167-72. PubMed PMID: 15794405.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Autoimmune urticaria. Treatment with methotrexate]. AU - Montero Mora,Patricia, AU - González Pérez,Maria del Carmen, AU - Almeida Arvizu,Victor, AU - Matta Campos,Juan José, PY - 2005/3/30/pubmed PY - 2005/5/4/medline PY - 2005/3/30/entrez SP - 167 EP - 72 JF - Revista alergia Mexico (Tecamachalco, Puebla, Mexico : 1993) JO - Rev Alerg Mex VL - 51 IS - 5 N2 - BACKGROUND: It has been established that 27-50% of patients with idiopathic chronic urticaria have antibodies directed against the alpha chain of the high-affinity IgE receptor, which are indirectly detected by cutaneous tests with autoserum. Thus, an autoimmune urticaria diagnosis can be settled. OBJECTIVE: To prove methotrexate's efficiency in patients with autoimmune urticaria. MATERIAL AND METHODS: Seven patients took part in the study. A series of tests was performed in order to rule out any possible infectious, metabolic, or physical etiology. Initial treatment with methotrexate with doses of 2.5 mg every 12 hours, two days a week was provided. In case there were no toxicity data, doses would increase to three days a week for a 6-week period. RESULTS: Statistically significant improvement was observed in the itching, as well as the presence of spots, repercussion on daily activities, sleep disorders. There was no statistical difference regarding the extension of the lesions and the presence of angioedema. Adverse effects were not significant. CONCLUSION: We conclude that methotrexate is effective in the treatment of autoimmune urticaria. SN - 0002-5151 UR - https://www.unboundmedicine.com/medline/citation/15794405/[Autoimmune_urticaria__Treatment_with_methotrexate]_ DB - PRIME DP - Unbound Medicine ER -