Tags

Type your tag names separated by a space and hit enter

Placebo-controlled clinical trial evaluating a 10% hydrogen peroxide whitening strip.
J Clin Dent. 2004; 15(4):118-22.JC

Abstract

OBJECTIVE

A placebo-controlled clinical trial was conducted to evaluate the effectiveness and safety of a 10% hydrogen peroxide strip-based whitening system in subjects with tooth discoloration and no previous history of tooth whitening.

METHODOLOGY

Informed consent was obtained, and 39 healthy adults were randomly assigned to either 10% hydrogen peroxide whitening strips (Crest Whitestrips Premium) or placebo strips with no peroxide. Strips were used unsupervised twice daily for 30 minutes over a seven-day period. At day four and day eight, tooth color (L*a*b*) was measured on the maxillary anterior teeth from standard digital images, and safety was assessed from examinations and subject reports.

RESULTS

After three treatment days, the 10% hydrogen peroxide strip group had significant (p < 0.0001) color improvement from baseline, with means (SD) for deltab* and deltaL* of -1.57 (0.472) and 1.72 (0.619), respectively. Continued strip use from day four to day eight resulted in significant (p < 0.002) incremental improvement in both yellowness and lightness. By the end of treatment (day eight), the adjusted mean (SE) color change between groups was -2.20 (0.275) for deltab* and 2.24 (0.254) for deltaL*, a highly significant (p < 0.0001) color improvement for the 10% hydrogen peroxide group relative to placebo, of similar absolute magnitude for deltab* and deltaL*. Treatment with the 10% hydrogen peroxide strips was well-tolerated, with tooth sensitivity and oral irritation representing the most common findings.

CONCLUSION

In this double-blind, placebo-controlled clinical trial, statistically significant tooth whitening was evident after three days' treatment with 10% hydrogen peroxide whitening strips, and color improved with continued usage over seven days.

Authors+Show Affiliations

The Procter & Gamble Company, Health Care Research Center, Mason, OH, USA. gerlach.rw@pg.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15794457

Citation

Gerlach, Robert W., et al. "Placebo-controlled Clinical Trial Evaluating a 10% Hydrogen Peroxide Whitening Strip." The Journal of Clinical Dentistry, vol. 15, no. 4, 2004, pp. 118-22.
Gerlach RW, Sagel PA, Barker ML, et al. Placebo-controlled clinical trial evaluating a 10% hydrogen peroxide whitening strip. J Clin Dent. 2004;15(4):118-22.
Gerlach, R. W., Sagel, P. A., Barker, M. L., Karpinia, K. A., & Magnusson, I. (2004). Placebo-controlled clinical trial evaluating a 10% hydrogen peroxide whitening strip. The Journal of Clinical Dentistry, 15(4), 118-22.
Gerlach RW, et al. Placebo-controlled Clinical Trial Evaluating a 10% Hydrogen Peroxide Whitening Strip. J Clin Dent. 2004;15(4):118-22. PubMed PMID: 15794457.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Placebo-controlled clinical trial evaluating a 10% hydrogen peroxide whitening strip. AU - Gerlach,Robert W, AU - Sagel,Paul A, AU - Barker,Matthew L, AU - Karpinia,Katherine A, AU - Magnusson,Ingvar, PY - 2005/3/30/pubmed PY - 2005/5/4/medline PY - 2005/3/30/entrez SP - 118 EP - 22 JF - The Journal of clinical dentistry JO - J Clin Dent VL - 15 IS - 4 N2 - OBJECTIVE: A placebo-controlled clinical trial was conducted to evaluate the effectiveness and safety of a 10% hydrogen peroxide strip-based whitening system in subjects with tooth discoloration and no previous history of tooth whitening. METHODOLOGY: Informed consent was obtained, and 39 healthy adults were randomly assigned to either 10% hydrogen peroxide whitening strips (Crest Whitestrips Premium) or placebo strips with no peroxide. Strips were used unsupervised twice daily for 30 minutes over a seven-day period. At day four and day eight, tooth color (L*a*b*) was measured on the maxillary anterior teeth from standard digital images, and safety was assessed from examinations and subject reports. RESULTS: After three treatment days, the 10% hydrogen peroxide strip group had significant (p < 0.0001) color improvement from baseline, with means (SD) for deltab* and deltaL* of -1.57 (0.472) and 1.72 (0.619), respectively. Continued strip use from day four to day eight resulted in significant (p < 0.002) incremental improvement in both yellowness and lightness. By the end of treatment (day eight), the adjusted mean (SE) color change between groups was -2.20 (0.275) for deltab* and 2.24 (0.254) for deltaL*, a highly significant (p < 0.0001) color improvement for the 10% hydrogen peroxide group relative to placebo, of similar absolute magnitude for deltab* and deltaL*. Treatment with the 10% hydrogen peroxide strips was well-tolerated, with tooth sensitivity and oral irritation representing the most common findings. CONCLUSION: In this double-blind, placebo-controlled clinical trial, statistically significant tooth whitening was evident after three days' treatment with 10% hydrogen peroxide whitening strips, and color improved with continued usage over seven days. SN - 0895-8831 UR - https://www.unboundmedicine.com/medline/citation/15794457/Placebo_controlled_clinical_trial_evaluating_a_10_hydrogen_peroxide_whitening_strip_ DB - PRIME DP - Unbound Medicine ER -