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Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues.
Toxicol Lett. 2005 May 16; 157(1):1-8.TL

Abstract

Intraperitoneal injection of the iron-chelate, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. A sub-lethal dose of Fe-NTA (15 mg Fe/kg body weight) was administered IP to rats; animals were sacrificed and liver, kidney and plasma were collected 1-4 h after injection. In response to the Fe-NTA administration, there were significant time-dependent reductions of the levels of total lipids, cholesterol and total unsaturated fatty acids, and a rise in the concentrations of conjugated dienes, 7-ketocholesterol and fatty acids hydroperoxides, showing a pattern inversely correlated in plasma, kidney and liver. Cholesterol level decreased significantly from 1 h after injection in the kidney and 3-4 h in the plasma and liver of treated rats. This is the first report on cholesterol reduction and accumulated 7-ketocholesterol in the tissues of rats treated with Fe-NTA as a consequence of lipid peroxidation.

Authors+Show Affiliations

Dip. Biologia Sperimentale, Sez. Patologia Sperimentale, Università degli Studi di Cagliari, Cittadella Universitaria, Km 4.5 SS 554, 09042 Monserrato, Cagliari, Italy. anrosa@unica.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15795088

Citation

Rosa, Antonella, et al. "Cholesterol as Target of Fe-NTA-induced Lipid Peroxidation in Rat Tissues." Toxicology Letters, vol. 157, no. 1, 2005, pp. 1-8.
Rosa A, Deiana M, Corona G, et al. Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues. Toxicol Lett. 2005;157(1):1-8.
Rosa, A., Deiana, M., Corona, G., Atzeri, A., Incani, A., & Dessì, M. A. (2005). Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues. Toxicology Letters, 157(1), 1-8.
Rosa A, et al. Cholesterol as Target of Fe-NTA-induced Lipid Peroxidation in Rat Tissues. Toxicol Lett. 2005 May 16;157(1):1-8. PubMed PMID: 15795088.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cholesterol as target of Fe-NTA-induced lipid peroxidation in rat tissues. AU - Rosa,Antonella, AU - Deiana,Monica, AU - Corona,Giulia, AU - Atzeri,Angela, AU - Incani,Alessandra, AU - Dessì,M Assunta, PY - 2004/09/20/received PY - 2004/12/08/revised PY - 2004/12/14/accepted PY - 2005/3/30/pubmed PY - 2005/5/11/medline PY - 2005/3/30/entrez SP - 1 EP - 8 JF - Toxicology letters JO - Toxicol Lett VL - 157 IS - 1 N2 - Intraperitoneal injection of the iron-chelate, ferric-nitrilotriacetate (Fe-NTA), induces renal proximal tubular damage associated with oxidative damage in vivo. A sub-lethal dose of Fe-NTA (15 mg Fe/kg body weight) was administered IP to rats; animals were sacrificed and liver, kidney and plasma were collected 1-4 h after injection. In response to the Fe-NTA administration, there were significant time-dependent reductions of the levels of total lipids, cholesterol and total unsaturated fatty acids, and a rise in the concentrations of conjugated dienes, 7-ketocholesterol and fatty acids hydroperoxides, showing a pattern inversely correlated in plasma, kidney and liver. Cholesterol level decreased significantly from 1 h after injection in the kidney and 3-4 h in the plasma and liver of treated rats. This is the first report on cholesterol reduction and accumulated 7-ketocholesterol in the tissues of rats treated with Fe-NTA as a consequence of lipid peroxidation. SN - 0378-4274 UR - https://www.unboundmedicine.com/medline/citation/15795088/Cholesterol_as_target_of_Fe_NTA_induced_lipid_peroxidation_in_rat_tissues_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-4274(05)00007-X DB - PRIME DP - Unbound Medicine ER -