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Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis.
J Nutr. 2005 Apr; 135(4):687-94.JN

Abstract

Previous studies proposed a protective role of the dietary intake of (n-3) PUFA in human inflammatory bowel disease (IBD), but almost no studies have been performed using olive oil. The aims of the present study were to test the beneficial effects of an olive oil-based diet with or without fish oil, rich in (n-3) PUFA, in the dextran sodium sulfate (DSS) model of rat colitis and to elucidate the mechanisms involved in their potential beneficial effects, with special attention to the production of some of the mediators involved in the intestinal inflammatory response, such as leukotriene B(4) (LTB(4)), tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO). Rats were fed the different diets for 2 wk before colitis induction and thereafter until colonic evaluation 15 d later. Colitic rats fed the olive oil-based diet had a lower colonic inflammatory response than those fed the soybean oil diet, and this beneficial effect was increased by the dietary incorporation of (n-3) PUFA. A restoration of colonic glutathione levels and lower colonic NO synthase expression occurred in all colitic rats fed an olive oil diet compared with the control colitic group that consumed the soybean oil diet. However, (n-3) PUFA incorporation into an olive oil diet significantly decreased colonic TNFalpha and LTB(4) levels compared with colitic rats that were not supplemented with fish oil. These results affirm the benefits of an olive oil diet in the management of IBD, which are further enhanced by the addition of (n-3) PUFA.

Authors+Show Affiliations

Department of Pharmacology, School of Pharmacy, University of Granada, Granada, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15795419

Citation

Camuesco, Desirée, et al. "Dietary Olive Oil Supplemented With Fish Oil, Rich in EPA and DHA (n-3) Polyunsaturated Fatty Acids, Attenuates Colonic Inflammation in Rats With DSS-induced Colitis." The Journal of Nutrition, vol. 135, no. 4, 2005, pp. 687-94.
Camuesco D, Gálvez J, Nieto A, et al. Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis. J Nutr. 2005;135(4):687-94.
Camuesco, D., Gálvez, J., Nieto, A., Comalada, M., Rodríguez-Cabezas, M. E., Concha, A., Xaus, J., & Zarzuelo, A. (2005). Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis. The Journal of Nutrition, 135(4), 687-94.
Camuesco D, et al. Dietary Olive Oil Supplemented With Fish Oil, Rich in EPA and DHA (n-3) Polyunsaturated Fatty Acids, Attenuates Colonic Inflammation in Rats With DSS-induced Colitis. J Nutr. 2005;135(4):687-94. PubMed PMID: 15795419.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Dietary olive oil supplemented with fish oil, rich in EPA and DHA (n-3) polyunsaturated fatty acids, attenuates colonic inflammation in rats with DSS-induced colitis. AU - Camuesco,Desirée, AU - Gálvez,Julio, AU - Nieto,Ana, AU - Comalada,Mònica, AU - Rodríguez-Cabezas,M Elena, AU - Concha,Angel, AU - Xaus,Jordi, AU - Zarzuelo,Antonio, PY - 2005/3/30/pubmed PY - 2005/6/1/medline PY - 2005/3/30/entrez SP - 687 EP - 94 JF - The Journal of nutrition JO - J. Nutr. VL - 135 IS - 4 N2 - Previous studies proposed a protective role of the dietary intake of (n-3) PUFA in human inflammatory bowel disease (IBD), but almost no studies have been performed using olive oil. The aims of the present study were to test the beneficial effects of an olive oil-based diet with or without fish oil, rich in (n-3) PUFA, in the dextran sodium sulfate (DSS) model of rat colitis and to elucidate the mechanisms involved in their potential beneficial effects, with special attention to the production of some of the mediators involved in the intestinal inflammatory response, such as leukotriene B(4) (LTB(4)), tumor necrosis factor alpha (TNFalpha) and nitric oxide (NO). Rats were fed the different diets for 2 wk before colitis induction and thereafter until colonic evaluation 15 d later. Colitic rats fed the olive oil-based diet had a lower colonic inflammatory response than those fed the soybean oil diet, and this beneficial effect was increased by the dietary incorporation of (n-3) PUFA. A restoration of colonic glutathione levels and lower colonic NO synthase expression occurred in all colitic rats fed an olive oil diet compared with the control colitic group that consumed the soybean oil diet. However, (n-3) PUFA incorporation into an olive oil diet significantly decreased colonic TNFalpha and LTB(4) levels compared with colitic rats that were not supplemented with fish oil. These results affirm the benefits of an olive oil diet in the management of IBD, which are further enhanced by the addition of (n-3) PUFA. SN - 0022-3166 UR - https://www.unboundmedicine.com/medline/citation/15795419/Dietary_olive_oil_supplemented_with_fish_oil_rich_in_EPA_and_DHA__n_3__polyunsaturated_fatty_acids_attenuates_colonic_inflammation_in_rats_with_DSS_induced_colitis_ L2 - https://academic.oup.com/jn/article-lookup/doi/10.1093/jn/135.4.687 DB - PRIME DP - Unbound Medicine ER -