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Hypocholesterolemic effects of a flavonoid-rich extract of Hypericum perforatum L. in rats fed a cholesterol-rich diet.
J Agric Food Chem. 2005 Apr 06; 53(7):2462-6.JA

Abstract

In a previous study, a flavonoid-rich extract of Hypericum perforatum L. (FEHP) was prepared and its antioxidant activity was determined by a series of models in vitro. In this study, the hypocholesterolemic effects of FEHP in rats fed a cholesterol-rich diet were tested. Forty Wistar rats fed a standard laboratory diet or a cholesterol-rich diet for 16 weeks were used. The serum lipid levels, as well as malondialdehyde (MDA) and activity of superoxide dismutase (SOD) and catalase (CAT) in serum and liver, were examined. Cholesterol-rich diet induced hypercholesterolemia was manifested in the elevation of serum lipid levels such as total cholesterol (TC), total triglycerides (TG), and low density lipoprotein cholesterol (LDL-C). Administration of middle-dose (75 mg/kg of BW/day) and high-dose (150 mg/kg of BW/day) FEHP significantly lowered the serum levels of TC, TG, and LDL-C, while increasing the serum level of high density lipoprotein cholesterol (HDL-C). Also, the content of MDA in serum and liver decreased significantly after oral administration of FEHP compared with those of rats fed a cholesterol-rich diet. In addition, FEHP increased the activity of SOD in serum and liver, but the activity of CAT was significantly elevated only in liver. These results suggested that the hypocholesterolemic effects of FEHP might be due to its abilities to lower serum TC, TG, and LDL-C levels as well as to slow the lipid peroxidation process and to enhance the antioxidant enzyme activity.

Authors+Show Affiliations

State Key Laboratory of Bioreactor Engineering, New World Institute of Biotechnology, East China University of Science and Technology, Shanghai 200237, China.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15796580

Citation

Zou, Yanping, et al. "Hypocholesterolemic Effects of a Flavonoid-rich Extract of Hypericum Perforatum L. in Rats Fed a Cholesterol-rich Diet." Journal of Agricultural and Food Chemistry, vol. 53, no. 7, 2005, pp. 2462-6.
Zou Y, Lu Y, Wei D. Hypocholesterolemic effects of a flavonoid-rich extract of Hypericum perforatum L. in rats fed a cholesterol-rich diet. J Agric Food Chem. 2005;53(7):2462-6.
Zou, Y., Lu, Y., & Wei, D. (2005). Hypocholesterolemic effects of a flavonoid-rich extract of Hypericum perforatum L. in rats fed a cholesterol-rich diet. Journal of Agricultural and Food Chemistry, 53(7), 2462-6.
Zou Y, Lu Y, Wei D. Hypocholesterolemic Effects of a Flavonoid-rich Extract of Hypericum Perforatum L. in Rats Fed a Cholesterol-rich Diet. J Agric Food Chem. 2005 Apr 6;53(7):2462-6. PubMed PMID: 15796580.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hypocholesterolemic effects of a flavonoid-rich extract of Hypericum perforatum L. in rats fed a cholesterol-rich diet. AU - Zou,Yanping, AU - Lu,Yanhua, AU - Wei,Dongzhi, PY - 2005/3/31/pubmed PY - 2005/5/19/medline PY - 2005/3/31/entrez SP - 2462 EP - 6 JF - Journal of agricultural and food chemistry JO - J. Agric. Food Chem. VL - 53 IS - 7 N2 - In a previous study, a flavonoid-rich extract of Hypericum perforatum L. (FEHP) was prepared and its antioxidant activity was determined by a series of models in vitro. In this study, the hypocholesterolemic effects of FEHP in rats fed a cholesterol-rich diet were tested. Forty Wistar rats fed a standard laboratory diet or a cholesterol-rich diet for 16 weeks were used. The serum lipid levels, as well as malondialdehyde (MDA) and activity of superoxide dismutase (SOD) and catalase (CAT) in serum and liver, were examined. Cholesterol-rich diet induced hypercholesterolemia was manifested in the elevation of serum lipid levels such as total cholesterol (TC), total triglycerides (TG), and low density lipoprotein cholesterol (LDL-C). Administration of middle-dose (75 mg/kg of BW/day) and high-dose (150 mg/kg of BW/day) FEHP significantly lowered the serum levels of TC, TG, and LDL-C, while increasing the serum level of high density lipoprotein cholesterol (HDL-C). Also, the content of MDA in serum and liver decreased significantly after oral administration of FEHP compared with those of rats fed a cholesterol-rich diet. In addition, FEHP increased the activity of SOD in serum and liver, but the activity of CAT was significantly elevated only in liver. These results suggested that the hypocholesterolemic effects of FEHP might be due to its abilities to lower serum TC, TG, and LDL-C levels as well as to slow the lipid peroxidation process and to enhance the antioxidant enzyme activity. SN - 0021-8561 UR - https://www.unboundmedicine.com/medline/citation/15796580/Hypocholesterolemic_effects_of_a_flavonoid_rich_extract_of_Hypericum_perforatum_L__in_rats_fed_a_cholesterol_rich_diet_ L2 - https://dx.doi.org/10.1021/jf048469r DB - PRIME DP - Unbound Medicine ER -