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BRCA1 and pancreatic cancer: pedigree findings and their causal relationships.
Cancer Genet Cytogenet 2005; 158(2):119-25CG

Abstract

Anecdotal reports and series studies indicate that 5-10% of pancreatic cancer (PC) cases are familial. In addition, PC is associated with a variety of hereditary cancer syndromes. PC appears to be an integral cancer in the hereditary breast-ovarian cancer (HBOC) syndrome, with most notice given to the role of BRCA2. Our purpose is to call attention to BRCA1, which also predisposes to PC. Using data from our familial breast cancer registry, we identified 19 BRCA1/2 families that contain PC affecteds in the pedigrees, 15 with BRCA1 mutations and 4 with BRCA2 mutations. The association between BRCA2 and pancreatic cancer is well established; however, a definite link with pancreatic cancer in families carrying a BRCA1 mutation has been far less studied. Thus, the focus of this report is on 9 of the 15 BRCA1 families, in which PC affecteds were either confirmed carriers of the BRCA1 mutation or were inferred as probable obligate BRCA1 mutation carriers. The numbers are small, but nevertheless illustrate the finding of others of an apparent association between PC and BRCA1-mutation-bearing families. Given the dismal prognosis of PC, with the only current hope for survival being through surgical extirpation of the pancreas prior to metastasis, it is prudent that we realize the potential predisposition toward PC via BRCA1, in the hope of early diagnosis and prevention.

Authors+Show Affiliations

Department of Preventive Medicine, Creighton University School of Medicine, 2500 California Plaza, Omaha, NE 68178, USA. htlynch@creighton.eduNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15796958

Citation

Lynch, Henry T., et al. "BRCA1 and Pancreatic Cancer: Pedigree Findings and Their Causal Relationships." Cancer Genetics and Cytogenetics, vol. 158, no. 2, 2005, pp. 119-25.
Lynch HT, Deters CA, Snyder CL, et al. BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. Cancer Genet Cytogenet. 2005;158(2):119-25.
Lynch, H. T., Deters, C. A., Snyder, C. L., Lynch, J. F., Villeneuve, P., Silberstein, J., ... Brand, R. E. (2005). BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. Cancer Genetics and Cytogenetics, 158(2), pp. 119-25.
Lynch HT, et al. BRCA1 and Pancreatic Cancer: Pedigree Findings and Their Causal Relationships. Cancer Genet Cytogenet. 2005 Apr 15;158(2):119-25. PubMed PMID: 15796958.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - BRCA1 and pancreatic cancer: pedigree findings and their causal relationships. AU - Lynch,Henry T, AU - Deters,Carolyn A, AU - Snyder,Carrie L, AU - Lynch,Jane F, AU - Villeneuve,Pierre, AU - Silberstein,Julie, AU - Martin,Holly, AU - Narod,Steven A, AU - Brand,Randall E, PY - 2004/07/14/received PY - 2004/10/05/revised PY - 2004/10/06/accepted PY - 2005/3/31/pubmed PY - 2005/5/10/medline PY - 2005/3/31/entrez SP - 119 EP - 25 JF - Cancer genetics and cytogenetics JO - Cancer Genet. Cytogenet. VL - 158 IS - 2 N2 - Anecdotal reports and series studies indicate that 5-10% of pancreatic cancer (PC) cases are familial. In addition, PC is associated with a variety of hereditary cancer syndromes. PC appears to be an integral cancer in the hereditary breast-ovarian cancer (HBOC) syndrome, with most notice given to the role of BRCA2. Our purpose is to call attention to BRCA1, which also predisposes to PC. Using data from our familial breast cancer registry, we identified 19 BRCA1/2 families that contain PC affecteds in the pedigrees, 15 with BRCA1 mutations and 4 with BRCA2 mutations. The association between BRCA2 and pancreatic cancer is well established; however, a definite link with pancreatic cancer in families carrying a BRCA1 mutation has been far less studied. Thus, the focus of this report is on 9 of the 15 BRCA1 families, in which PC affecteds were either confirmed carriers of the BRCA1 mutation or were inferred as probable obligate BRCA1 mutation carriers. The numbers are small, but nevertheless illustrate the finding of others of an apparent association between PC and BRCA1-mutation-bearing families. Given the dismal prognosis of PC, with the only current hope for survival being through surgical extirpation of the pancreas prior to metastasis, it is prudent that we realize the potential predisposition toward PC via BRCA1, in the hope of early diagnosis and prevention. SN - 0165-4608 UR - https://www.unboundmedicine.com/medline/citation/15796958/BRCA1_and_pancreatic_cancer:_pedigree_findings_and_their_causal_relationships_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0165-4608(04)00478-9 DB - PRIME DP - Unbound Medicine ER -