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Effects of creatine on thermoregulatory responses while exercising in the heat.
Nutrition. 2005 Mar; 21(3):301-7.N

Abstract

OBJECTIVE

We hypothesized that creatine supplementation would interfere with normal body fluid shifts that occur during exercise in a hot environment due to its osmotic effect intracellularly. This study examined the effects of acute creatine loading (20 g/d for 5 d) on the thermoregulatory response of the body during a bout of exercise at 39 degrees C.

METHODS

Subjects (15 men and 1 woman) performed a cycle test of maximum oxygen consumption to determine the proper work rate for the heat-stress test (40 min at 55% maximum oxygen consumption at 39 degrees C) and were assigned to a creatine group (n = 8) or a placebo group (n = 8) in a double-blind fashion. Each group performed the heat-stress test on two separate occasions: before supplementation and after supplementation (20 g/d of creatine with Gatorade or Solka-floc plus Gatorade). Dependent variables included rectal temperature, mean skin temperature, mean body temperature, and perceived thermal sensation.

RESULTS

Repeated measure analysis of variance showed a significant (P < or = 0.05) increase in body weight in the group supplemented with Gatorade. Core temperature was significantly lower after supplementation for both groups combined (before supplementation at 37.85 degrees C and after supplementation at 37.7 degrees C), with no difference between groups. A significant three-way interaction (group x trial x time) was also found for rectal temperature, with both groups having significantly lower rectal temperature after supplementation. Mean body and mean skin temperatures showed no differences.

CONCLUSIONS

Short-term creatine supplementation (20 g/d for 5 d) did not have a negative effect on thermoregulatory responses during exercise at 39 degrees C.

Authors+Show Affiliations

Ohio Research Group, Wadsworth, Ohio, USA. rwmendel@wadsnet.comNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article

Language

eng

PubMed ID

15797670

Citation

Mendel, Ronald W., et al. "Effects of Creatine On Thermoregulatory Responses While Exercising in the Heat." Nutrition (Burbank, Los Angeles County, Calif.), vol. 21, no. 3, 2005, pp. 301-7.
Mendel RW, Blegen M, Cheatham C, et al. Effects of creatine on thermoregulatory responses while exercising in the heat. Nutrition. 2005;21(3):301-7.
Mendel, R. W., Blegen, M., Cheatham, C., Antonio, J., & Ziegenfuss, T. (2005). Effects of creatine on thermoregulatory responses while exercising in the heat. Nutrition (Burbank, Los Angeles County, Calif.), 21(3), 301-7.
Mendel RW, et al. Effects of Creatine On Thermoregulatory Responses While Exercising in the Heat. Nutrition. 2005;21(3):301-7. PubMed PMID: 15797670.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of creatine on thermoregulatory responses while exercising in the heat. AU - Mendel,Ronald W, AU - Blegen,Mark, AU - Cheatham,Chris, AU - Antonio,Jose, AU - Ziegenfuss,Tim, PY - 2004/02/23/received PY - 2004/06/21/accepted PY - 2005/3/31/pubmed PY - 2005/9/21/medline PY - 2005/3/31/entrez SP - 301 EP - 7 JF - Nutrition (Burbank, Los Angeles County, Calif.) JO - Nutrition VL - 21 IS - 3 N2 - OBJECTIVE: We hypothesized that creatine supplementation would interfere with normal body fluid shifts that occur during exercise in a hot environment due to its osmotic effect intracellularly. This study examined the effects of acute creatine loading (20 g/d for 5 d) on the thermoregulatory response of the body during a bout of exercise at 39 degrees C. METHODS: Subjects (15 men and 1 woman) performed a cycle test of maximum oxygen consumption to determine the proper work rate for the heat-stress test (40 min at 55% maximum oxygen consumption at 39 degrees C) and were assigned to a creatine group (n = 8) or a placebo group (n = 8) in a double-blind fashion. Each group performed the heat-stress test on two separate occasions: before supplementation and after supplementation (20 g/d of creatine with Gatorade or Solka-floc plus Gatorade). Dependent variables included rectal temperature, mean skin temperature, mean body temperature, and perceived thermal sensation. RESULTS: Repeated measure analysis of variance showed a significant (P < or = 0.05) increase in body weight in the group supplemented with Gatorade. Core temperature was significantly lower after supplementation for both groups combined (before supplementation at 37.85 degrees C and after supplementation at 37.7 degrees C), with no difference between groups. A significant three-way interaction (group x trial x time) was also found for rectal temperature, with both groups having significantly lower rectal temperature after supplementation. Mean body and mean skin temperatures showed no differences. CONCLUSIONS: Short-term creatine supplementation (20 g/d for 5 d) did not have a negative effect on thermoregulatory responses during exercise at 39 degrees C. SN - 0899-9007 UR - https://www.unboundmedicine.com/medline/citation/15797670/Effects_of_creatine_on_thermoregulatory_responses_while_exercising_in_the_heat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0899-9007(04)00289-8 DB - PRIME DP - Unbound Medicine ER -