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Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography.
J Pharm Biomed Anal. 2005 Apr 01; 37(4):663-7.JP

Abstract

High-performance liquid chromatography (HPLC) was used for the simultaneous quantification of the H(1)-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride. Both compounds were detected at the wavelength of 214 nm. The influence of the mobile phase and the detection wavelength was evaluated and optimized. This method was used to assay various samples from studies of the commercial preparation Semprex-D capsules. The method was found to be accurate, specific, selective, rapid, and versatile for use in routine quality control analyses.

Authors+Show Affiliations

Faculty of Pharmacy, University of Manitoba, 50 Sifton Road, Winnipeg, Manitoba, Canada R3T 2N2. xgu@cc.umanitoba.caNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15797786

Citation

Gu, Xiaochen, et al. "Simultaneous Analysis of the H1-antihistamine Acrivastine and the Decongestant Pseudoephedrine Hydrochloride By High-performance Liquid Chromatography." Journal of Pharmaceutical and Biomedical Analysis, vol. 37, no. 4, 2005, pp. 663-7.
Gu X, Li H, Macnair KR, et al. Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography. J Pharm Biomed Anal. 2005;37(4):663-7.
Gu, X., Li, H., Macnair, K. R., Simons, F. E., & Simons, K. J. (2005). Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography. Journal of Pharmaceutical and Biomedical Analysis, 37(4), 663-7.
Gu X, et al. Simultaneous Analysis of the H1-antihistamine Acrivastine and the Decongestant Pseudoephedrine Hydrochloride By High-performance Liquid Chromatography. J Pharm Biomed Anal. 2005 Apr 1;37(4):663-7. PubMed PMID: 15797786.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simultaneous analysis of the H1-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride by high-performance liquid chromatography. AU - Gu,Xiaochen, AU - Li,Hongtao, AU - Macnair,Kyle R, AU - Simons,F Estelle R, AU - Simons,Keith J, Y1 - 2004/12/25/ PY - 2004/07/28/received PY - 2004/10/30/accepted PY - 2005/3/31/pubmed PY - 2005/8/16/medline PY - 2005/3/31/entrez SP - 663 EP - 7 JF - Journal of pharmaceutical and biomedical analysis JO - J Pharm Biomed Anal VL - 37 IS - 4 N2 - High-performance liquid chromatography (HPLC) was used for the simultaneous quantification of the H(1)-antihistamine acrivastine and the decongestant pseudoephedrine hydrochloride. Both compounds were detected at the wavelength of 214 nm. The influence of the mobile phase and the detection wavelength was evaluated and optimized. This method was used to assay various samples from studies of the commercial preparation Semprex-D capsules. The method was found to be accurate, specific, selective, rapid, and versatile for use in routine quality control analyses. SN - 0731-7085 UR - https://www.unboundmedicine.com/medline/citation/15797786/Simultaneous_analysis_of_the_H1_antihistamine_acrivastine_and_the_decongestant_pseudoephedrine_hydrochloride_by_high_performance_liquid_chromatography_ DB - PRIME DP - Unbound Medicine ER -