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Antioxidant activity of isoacteoside from Clerodendron trichotomum.
J Toxicol Environ Health A. 2005 Mar 12; 68(5):389-400.JT

Abstract

The antioxidant properties of isoacteoside, isolated from Clerodendron trichotomum (Verbenaceae), were investigated. This compound scavenged intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and prevented lipid peroxidation. This radical scavenging activity of isoacteoside protected cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2). Furthermore, isoacteoside reduced the apoptotic cells formation induced by H2O2, as demonstrated by the decreased number of sub-G1 hypo-diploid cells and apoptotic cell body formation. However, isoacteoside increased the activities of cellular antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Taken together, these findings suggest that isoacteoside, isolated from C. trichotomum, possesses antioxidant properties.

Authors+Show Affiliations

Natural Products Research Institute and College of Pharmacy, Seoul National University, Seoul, Korea.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15799629

Citation

Chae, Sungwook, et al. "Antioxidant Activity of Isoacteoside From Clerodendron Trichotomum." Journal of Toxicology and Environmental Health. Part A, vol. 68, no. 5, 2005, pp. 389-400.
Chae S, Kim JS, Kang KA, et al. Antioxidant activity of isoacteoside from Clerodendron trichotomum. J Toxicol Environ Health A. 2005;68(5):389-400.
Chae, S., Kim, J. S., Kang, K. A., Bu, H. D., Lee, Y., Seo, Y. R., Hyun, J. W., & Kang, S. S. (2005). Antioxidant activity of isoacteoside from Clerodendron trichotomum. Journal of Toxicology and Environmental Health. Part A, 68(5), 389-400.
Chae S, et al. Antioxidant Activity of Isoacteoside From Clerodendron Trichotomum. J Toxicol Environ Health A. 2005 Mar 12;68(5):389-400. PubMed PMID: 15799629.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Antioxidant activity of isoacteoside from Clerodendron trichotomum. AU - Chae,Sungwook, AU - Kim,Ju Sun, AU - Kang,Kyoung Ah, AU - Bu,Hyung Deuk, AU - Lee,Youngki, AU - Seo,Young Rok, AU - Hyun,Jin Won, AU - Kang,Sam Sik, PY - 2005/4/1/pubmed PY - 2005/4/13/medline PY - 2005/4/1/entrez SP - 389 EP - 400 JF - Journal of toxicology and environmental health. Part A JO - J Toxicol Environ Health A VL - 68 IS - 5 N2 - The antioxidant properties of isoacteoside, isolated from Clerodendron trichotomum (Verbenaceae), were investigated. This compound scavenged intracellular reactive oxygen species (ROS) and 1,1-diphenyl-2-picrylhydrazyl (DPPH) radical, and prevented lipid peroxidation. This radical scavenging activity of isoacteoside protected cell viability of Chinese hamster lung fibroblast (V79-4) cells exposed to hydrogen peroxide (H2O2). Furthermore, isoacteoside reduced the apoptotic cells formation induced by H2O2, as demonstrated by the decreased number of sub-G1 hypo-diploid cells and apoptotic cell body formation. However, isoacteoside increased the activities of cellular antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT). Taken together, these findings suggest that isoacteoside, isolated from C. trichotomum, possesses antioxidant properties. SN - 1528-7394 UR - https://www.unboundmedicine.com/medline/citation/15799629/Antioxidant_activity_of_isoacteoside_from_Clerodendron_trichotomum_ L2 - https://www.tandfonline.com/doi/full/10.1080/15287390590900750 DB - PRIME DP - Unbound Medicine ER -