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Intakes of calcium and vitamin D and risk of colorectal cancer in women.
Am J Epidemiol. 2005 Apr 15; 161(8):755-64.AJ

Abstract

In vivo and in vitro studies have suggested a protective role of calcium and vitamin D in the development of colorectal cancer. However, epidemiologic data have been inconclusive. The authors prospectively assessed intakes of calcium and vitamin D in relation to risk of colorectal cancer in a large, prospective, female cohort from the US Women's Health Study. In 1993, 39,876 women aged > or = 45 years and free of cardiovascular disease and cancer were enrolled in the study. During an average follow-up of 10 years, 223 of 36,976 women eligible for the present study developed colorectal cancer. Intakes of calcium and vitamin D from dietary sources and supplements were assessed with a baseline food frequency questionnaire. Cox proportional hazards regression was used to estimate relative risks and 95% confidence intervals. Intakes of total calcium and vitamin D were not associated with risk of colorectal cancer; multivariate relative risks comparing the highest with the lowest quintile were 1.20 (95% confidence interval: 0.79, 1.85; p for trend = 0.21) for total calcium and 1.34 (95% confidence interval: 0.84, 2.13; p for trend = 0.08) for total vitamin D. Intakes of both nutrients from specific types of sources, including diet and supplements, were also not significantly associated with colorectal cancer risk. Data provide little support for an association of calcium and vitamin D intake with colorectal cancer risk.

Authors+Show Affiliations

Lin J
Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. jhlin@rics.bwh.harvard.edu
Zhang SM
No affiliation info available
Cook NR
No affiliation info available
Manson JE
No affiliation info available
Lee IM
No affiliation info available
Buring JE
No affiliation info available

MeSH

Calcium, DietaryColorectal NeoplasmsDairy ProductsFemaleFollow-Up StudiesHumansMiddle AgedOdds RatioProportional Hazards ModelsProspective StudiesRisk AssessmentRisk FactorsSurveys and QuestionnairesUnited StatesVitamin D

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15800268

Clinical Trial Links

Women's Health Study (WHS): A Randomized Trial of Low-dose Aspirin and Vitamin E in the Primary Prevention of Cardiovascular Disease and Cancer

Citation

Lin, Jennifer, et al. "Intakes of Calcium and Vitamin D and Risk of Colorectal Cancer in Women." American Journal of Epidemiology, vol. 161, no. 8, 2005, pp. 755-64.
Lin J, Zhang SM, Cook NR, et al. Intakes of calcium and vitamin D and risk of colorectal cancer in women. Am J Epidemiol. 2005;161(8):755-64.
Lin, J., Zhang, S. M., Cook, N. R., Manson, J. E., Lee, I. M., & Buring, J. E. (2005). Intakes of calcium and vitamin D and risk of colorectal cancer in women. American Journal of Epidemiology, 161(8), 755-64.
Lin J, et al. Intakes of Calcium and Vitamin D and Risk of Colorectal Cancer in Women. Am J Epidemiol. 2005 Apr 15;161(8):755-64. PubMed PMID: 15800268.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intakes of calcium and vitamin D and risk of colorectal cancer in women. AU - Lin,Jennifer, AU - Zhang,Shumin M, AU - Cook,Nancy R, AU - Manson,JoAnn E, AU - Lee,I-Min, AU - Buring,Julie E, PY - 2005/4/1/pubmed PY - 2005/5/14/medline PY - 2005/4/1/entrez SP - 755 EP - 64 JF - American journal of epidemiology JO - Am J Epidemiol VL - 161 IS - 8 N2 - In vivo and in vitro studies have suggested a protective role of calcium and vitamin D in the development of colorectal cancer. However, epidemiologic data have been inconclusive. The authors prospectively assessed intakes of calcium and vitamin D in relation to risk of colorectal cancer in a large, prospective, female cohort from the US Women's Health Study. In 1993, 39,876 women aged > or = 45 years and free of cardiovascular disease and cancer were enrolled in the study. During an average follow-up of 10 years, 223 of 36,976 women eligible for the present study developed colorectal cancer. Intakes of calcium and vitamin D from dietary sources and supplements were assessed with a baseline food frequency questionnaire. Cox proportional hazards regression was used to estimate relative risks and 95% confidence intervals. Intakes of total calcium and vitamin D were not associated with risk of colorectal cancer; multivariate relative risks comparing the highest with the lowest quintile were 1.20 (95% confidence interval: 0.79, 1.85; p for trend = 0.21) for total calcium and 1.34 (95% confidence interval: 0.84, 2.13; p for trend = 0.08) for total vitamin D. Intakes of both nutrients from specific types of sources, including diet and supplements, were also not significantly associated with colorectal cancer risk. Data provide little support for an association of calcium and vitamin D intake with colorectal cancer risk. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15800268/Intakes_of_calcium_and_vitamin_D_and_risk_of_colorectal_cancer_in_women_ DB - PRIME DP - Unbound Medicine ER -