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Intakes of calcium and vitamin D and risk of colorectal cancer in women.

Abstract

In vivo and in vitro studies have suggested a protective role of calcium and vitamin D in the development of colorectal cancer. However, epidemiologic data have been inconclusive. The authors prospectively assessed intakes of calcium and vitamin D in relation to risk of colorectal cancer in a large, prospective, female cohort from the US Women's Health Study. In 1993, 39,876 women aged > or = 45 years and free of cardiovascular disease and cancer were enrolled in the study. During an average follow-up of 10 years, 223 of 36,976 women eligible for the present study developed colorectal cancer. Intakes of calcium and vitamin D from dietary sources and supplements were assessed with a baseline food frequency questionnaire. Cox proportional hazards regression was used to estimate relative risks and 95% confidence intervals. Intakes of total calcium and vitamin D were not associated with risk of colorectal cancer; multivariate relative risks comparing the highest with the lowest quintile were 1.20 (95% confidence interval: 0.79, 1.85; p for trend = 0.21) for total calcium and 1.34 (95% confidence interval: 0.84, 2.13; p for trend = 0.08) for total vitamin D. Intakes of both nutrients from specific types of sources, including diet and supplements, were also not significantly associated with colorectal cancer risk. Data provide little support for an association of calcium and vitamin D intake with colorectal cancer risk.

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  • Authors+Show Affiliations

    ,

    Division of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, MA 02215, USA. jhlin@rics.bwh.harvard.edu

    , , , ,

    Source

    American journal of epidemiology 161:8 2005 Apr 15 pg 755-64

    MeSH

    Calcium, Dietary
    Colorectal Neoplasms
    Dairy Products
    Female
    Follow-Up Studies
    Humans
    Middle Aged
    Odds Ratio
    Proportional Hazards Models
    Prospective Studies
    Risk Assessment
    Risk Factors
    Surveys and Questionnaires
    United States
    Vitamin D

    Pub Type(s)

    Journal Article
    Research Support, U.S. Gov't, P.H.S.

    Language

    eng

    PubMed ID

    15800268

    Citation

    Lin, Jennifer, et al. "Intakes of Calcium and Vitamin D and Risk of Colorectal Cancer in Women." American Journal of Epidemiology, vol. 161, no. 8, 2005, pp. 755-64.
    Lin J, Zhang SM, Cook NR, et al. Intakes of calcium and vitamin D and risk of colorectal cancer in women. Am J Epidemiol. 2005;161(8):755-64.
    Lin, J., Zhang, S. M., Cook, N. R., Manson, J. E., Lee, I. M., & Buring, J. E. (2005). Intakes of calcium and vitamin D and risk of colorectal cancer in women. American Journal of Epidemiology, 161(8), pp. 755-64.
    Lin J, et al. Intakes of Calcium and Vitamin D and Risk of Colorectal Cancer in Women. Am J Epidemiol. 2005 Apr 15;161(8):755-64. PubMed PMID: 15800268.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Intakes of calcium and vitamin D and risk of colorectal cancer in women. AU - Lin,Jennifer, AU - Zhang,Shumin M, AU - Cook,Nancy R, AU - Manson,JoAnn E, AU - Lee,I-Min, AU - Buring,Julie E, PY - 2005/4/1/pubmed PY - 2005/5/14/medline PY - 2005/4/1/entrez SP - 755 EP - 64 JF - American journal of epidemiology JO - Am. J. Epidemiol. VL - 161 IS - 8 N2 - In vivo and in vitro studies have suggested a protective role of calcium and vitamin D in the development of colorectal cancer. However, epidemiologic data have been inconclusive. The authors prospectively assessed intakes of calcium and vitamin D in relation to risk of colorectal cancer in a large, prospective, female cohort from the US Women's Health Study. In 1993, 39,876 women aged > or = 45 years and free of cardiovascular disease and cancer were enrolled in the study. During an average follow-up of 10 years, 223 of 36,976 women eligible for the present study developed colorectal cancer. Intakes of calcium and vitamin D from dietary sources and supplements were assessed with a baseline food frequency questionnaire. Cox proportional hazards regression was used to estimate relative risks and 95% confidence intervals. Intakes of total calcium and vitamin D were not associated with risk of colorectal cancer; multivariate relative risks comparing the highest with the lowest quintile were 1.20 (95% confidence interval: 0.79, 1.85; p for trend = 0.21) for total calcium and 1.34 (95% confidence interval: 0.84, 2.13; p for trend = 0.08) for total vitamin D. Intakes of both nutrients from specific types of sources, including diet and supplements, were also not significantly associated with colorectal cancer risk. Data provide little support for an association of calcium and vitamin D intake with colorectal cancer risk. SN - 0002-9262 UR - https://www.unboundmedicine.com/medline/citation/15800268/Intakes_of_calcium_and_vitamin_D_and_risk_of_colorectal_cancer_in_women_ L2 - https://academic.oup.com/aje/article-lookup/doi/10.1093/aje/kwi101 DB - PRIME DP - Unbound Medicine ER -