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Flavonoids and the aging brain.
J Physiol Pharmacol. 2005 Mar; 56 Suppl 1:23-36.JP

Abstract

Like in all other organs, the functional capacity of the human brain deteriorates over time. Pathological events such as oxidative stress, due to the elevated release of free radicals and reactive oxygen or nitrogen species, the subsequently enhanced oxidative modification of lipids, protein, and nucleic acids, and the modulation of apoptotic signaling pathways contribute to loss of brain function. The identification of neuroprotective food components is one strategy to facilitate healthy brain aging. Flavonoids were shown to activate key enzymes in mitochondrial respiration and to protect neuronal cells by acting as antioxidants, thus breaking the vicious cycle of oxidative stress and tissue damage. Furthermore, recent data indicate a favorable effect of flavonoids on neuro-inflammatory events. Whereas most of these effects have been shown in vitro, limited data in vivo are available, suggesting a rather low penetration of flavonoids into the brain. Nevertheless, several reports support the concept that flavonoid intake inhibits certain biochemical processes of brain aging, and might thus prevent to some extent the decline of cognitive functions with aging as well as the development or the course of neurodegenerative diseases. However, more data are needed to assess the true impact of flavonoids on brain aging.

Authors+Show Affiliations

Institute of Pharmacology (ZAFES), Biocenter Niederursel, University of Frankfurt, Frankfurt am Main, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15800383

Citation

Schmitt-Schillig, S, et al. "Flavonoids and the Aging Brain." Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, vol. 56 Suppl 1, 2005, pp. 23-36.
Schmitt-Schillig S, Schaffer S, Weber CC, et al. Flavonoids and the aging brain. J Physiol Pharmacol. 2005;56 Suppl 1:23-36.
Schmitt-Schillig, S., Schaffer, S., Weber, C. C., Eckert, G. P., & Müller, W. E. (2005). Flavonoids and the aging brain. Journal of Physiology and Pharmacology : an Official Journal of the Polish Physiological Society, 56 Suppl 1, 23-36.
Schmitt-Schillig S, et al. Flavonoids and the Aging Brain. J Physiol Pharmacol. 2005;56 Suppl 1:23-36. PubMed PMID: 15800383.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Flavonoids and the aging brain. AU - Schmitt-Schillig,S, AU - Schaffer,S, AU - Weber,C C, AU - Eckert,G P, AU - Müller,W E, PY - 2005/01/31/received PY - 2005/02/15/accepted PY - 2005/4/1/pubmed PY - 2007/12/6/medline PY - 2005/4/1/entrez SP - 23 EP - 36 JF - Journal of physiology and pharmacology : an official journal of the Polish Physiological Society JO - J Physiol Pharmacol VL - 56 Suppl 1 N2 - Like in all other organs, the functional capacity of the human brain deteriorates over time. Pathological events such as oxidative stress, due to the elevated release of free radicals and reactive oxygen or nitrogen species, the subsequently enhanced oxidative modification of lipids, protein, and nucleic acids, and the modulation of apoptotic signaling pathways contribute to loss of brain function. The identification of neuroprotective food components is one strategy to facilitate healthy brain aging. Flavonoids were shown to activate key enzymes in mitochondrial respiration and to protect neuronal cells by acting as antioxidants, thus breaking the vicious cycle of oxidative stress and tissue damage. Furthermore, recent data indicate a favorable effect of flavonoids on neuro-inflammatory events. Whereas most of these effects have been shown in vitro, limited data in vivo are available, suggesting a rather low penetration of flavonoids into the brain. Nevertheless, several reports support the concept that flavonoid intake inhibits certain biochemical processes of brain aging, and might thus prevent to some extent the decline of cognitive functions with aging as well as the development or the course of neurodegenerative diseases. However, more data are needed to assess the true impact of flavonoids on brain aging. SN - 1899-1505 UR - https://www.unboundmedicine.com/medline/citation/15800383/Flavonoids_and_the_aging_brain_ L2 - https://medlineplus.gov/olderadulthealth.html DB - PRIME DP - Unbound Medicine ER -