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Screening women at high risk for breast cancer with mammography and magnetic resonance imaging.
Cancer. 2005 May 01; 103(9):1898-905.C

Abstract

BACKGROUND

The authors compared the performance of screening mammography versus magnetic resonance imaging (MRI) in women at genetically high risk for breast cancer.

METHODS

The authors conducted an international prospective study of screening mammography and MRI in asymptomatic, genetically high-risk women age >/= 25 years. Women with a history of breast cancer were eligible for a contralateral screening if they had been diagnosed within 5 years or a bilateral screening if they had been diagnosed > 5 years previously. All examinations (MRI, mammography, and clinical breast examination [CBE]) were performed within 90 days of each other.

RESULTS

In total, 390 eligible women were enrolled by 13 sites, and 367 women completed all study examinations. Imaging evaluations recommended 38 biopsies, and 27 biopsies were performed, resulting in 4 cancers diagnosed for an overall 1.1% cancer yield (95% confidence interval [95%CI], 0.3-2.8%). MRI detected all four cancers, whereas mammography detected one cancer. The diagnostic yield of mammography was 0.3% (95%CI, 0.01-1.5%). The yield of cancer by MRI alone was 0.8% (95%CI, - 0.3-2.0%). The biopsy recommendation rates for MRI and mammography were 8.5% (95%CI, 5.8-11.8%) and 2.2% (95%CI, 0.1-4.3%).

CONCLUSIONS

Screening MRI in high-risk women was capable of detecting mammographically and clinically occult breast cancer. Screening MRI resulted in 22 of 367 of women (6%) who had negative mammogram and negative CBE examinations undergoing biopsy, resulting in 3 additional cancers detected. MRI also resulted in 19 (5%) false-positive outcomes, which resulted in benign biopsies.

Authors+Show Affiliations

Department of Radiology, University of Washington, Seattle Cancer Care Alliance, Seattle, Washington 98109-1023, USA. lehman@seattlecca.orgNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15800894

Citation

Lehman, Constance D., et al. "Screening Women at High Risk for Breast Cancer With Mammography and Magnetic Resonance Imaging." Cancer, vol. 103, no. 9, 2005, pp. 1898-905.
Lehman CD, Blume JD, Weatherall P, et al. Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. Cancer. 2005;103(9):1898-905.
Lehman, C. D., Blume, J. D., Weatherall, P., Thickman, D., Hylton, N., Warner, E., Pisano, E., Schnitt, S. J., Gatsonis, C., Schnall, M., DeAngelis, G. A., Stomper, P., Rosen, E. L., O'Loughlin, M., Harms, S., & Bluemke, D. A. (2005). Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. Cancer, 103(9), 1898-905.
Lehman CD, et al. Screening Women at High Risk for Breast Cancer With Mammography and Magnetic Resonance Imaging. Cancer. 2005 May 1;103(9):1898-905. PubMed PMID: 15800894.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Screening women at high risk for breast cancer with mammography and magnetic resonance imaging. AU - Lehman,Constance D, AU - Blume,Jeffrey D, AU - Weatherall,Paul, AU - Thickman,David, AU - Hylton,Nola, AU - Warner,Ellen, AU - Pisano,Etta, AU - Schnitt,Stuart J, AU - Gatsonis,Constantine, AU - Schnall,Mitchell, AU - DeAngelis,Gia A, AU - Stomper,Paul, AU - Rosen,Eric L, AU - O'Loughlin,Michael, AU - Harms,Steven, AU - Bluemke,David A, AU - ,, PY - 2005/4/1/pubmed PY - 2005/6/9/medline PY - 2005/4/1/entrez SP - 1898 EP - 905 JF - Cancer JO - Cancer VL - 103 IS - 9 N2 - BACKGROUND: The authors compared the performance of screening mammography versus magnetic resonance imaging (MRI) in women at genetically high risk for breast cancer. METHODS: The authors conducted an international prospective study of screening mammography and MRI in asymptomatic, genetically high-risk women age >/= 25 years. Women with a history of breast cancer were eligible for a contralateral screening if they had been diagnosed within 5 years or a bilateral screening if they had been diagnosed > 5 years previously. All examinations (MRI, mammography, and clinical breast examination [CBE]) were performed within 90 days of each other. RESULTS: In total, 390 eligible women were enrolled by 13 sites, and 367 women completed all study examinations. Imaging evaluations recommended 38 biopsies, and 27 biopsies were performed, resulting in 4 cancers diagnosed for an overall 1.1% cancer yield (95% confidence interval [95%CI], 0.3-2.8%). MRI detected all four cancers, whereas mammography detected one cancer. The diagnostic yield of mammography was 0.3% (95%CI, 0.01-1.5%). The yield of cancer by MRI alone was 0.8% (95%CI, - 0.3-2.0%). The biopsy recommendation rates for MRI and mammography were 8.5% (95%CI, 5.8-11.8%) and 2.2% (95%CI, 0.1-4.3%). CONCLUSIONS: Screening MRI in high-risk women was capable of detecting mammographically and clinically occult breast cancer. Screening MRI resulted in 22 of 367 of women (6%) who had negative mammogram and negative CBE examinations undergoing biopsy, resulting in 3 additional cancers detected. MRI also resulted in 19 (5%) false-positive outcomes, which resulted in benign biopsies. SN - 0008-543X UR - https://www.unboundmedicine.com/medline/citation/15800894/Screening_women_at_high_risk_for_breast_cancer_with_mammography_and_magnetic_resonance_imaging_ L2 - https://doi.org/10.1002/cncr.20971 DB - PRIME DP - Unbound Medicine ER -