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Adsorptive stripping voltammetric determination of ambroxol.
Pharmazie. 2005 Mar; 60(3):193-6.P

Abstract

An electrochemical procedure for the determination of ambroxol in mucolytics was described. The method was based on adsorptive accumulation of the species at the hanging mercury drop electrode (HMDE), followed by one of different modes of stripping sweep, viz. direct current tast (DCT), differential pulse (DP), square wave (SW) and first harmonic alternating current (AC1). The behaviour of adsorptive stripping response was studied under various experimental conditions, e.g. type of supporting electrolyte, pH, accumulation time, pulse amplitude, scan rate and mode of sweep. In Britton-Robinson buffer solution, an irreversible reduction process involving transfer of one electron and one proton was took place. The response was linear over the 0.2-6 microg/ml concentration range. Determination of the compound in oral dosage forms was achieved using the standard addition method. The average of determinations obtained by the squarewave adsorptive voltammetric method with its relative standard deviation was 99.8 +/- 2.40%.

Authors+Show Affiliations

Microanalytical Chemistry Laboratory, Applied Organic Chemistry Department, National Research Centre, Dokki, Cairo, Egypt. ihihabib@yahoo.comNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15801671

Citation

Habib, I H I., and S I M. Zayed. "Adsorptive Stripping Voltammetric Determination of Ambroxol." Die Pharmazie, vol. 60, no. 3, 2005, pp. 193-6.
Habib IH, Zayed SI. Adsorptive stripping voltammetric determination of ambroxol. Pharmazie. 2005;60(3):193-6.
Habib, I. H., & Zayed, S. I. (2005). Adsorptive stripping voltammetric determination of ambroxol. Die Pharmazie, 60(3), 193-6.
Habib IH, Zayed SI. Adsorptive Stripping Voltammetric Determination of Ambroxol. Pharmazie. 2005;60(3):193-6. PubMed PMID: 15801671.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adsorptive stripping voltammetric determination of ambroxol. AU - Habib,I H I, AU - Zayed,S I M, PY - 2005/4/2/pubmed PY - 2005/4/29/medline PY - 2005/4/2/entrez SP - 193 EP - 6 JF - Die Pharmazie JO - Pharmazie VL - 60 IS - 3 N2 - An electrochemical procedure for the determination of ambroxol in mucolytics was described. The method was based on adsorptive accumulation of the species at the hanging mercury drop electrode (HMDE), followed by one of different modes of stripping sweep, viz. direct current tast (DCT), differential pulse (DP), square wave (SW) and first harmonic alternating current (AC1). The behaviour of adsorptive stripping response was studied under various experimental conditions, e.g. type of supporting electrolyte, pH, accumulation time, pulse amplitude, scan rate and mode of sweep. In Britton-Robinson buffer solution, an irreversible reduction process involving transfer of one electron and one proton was took place. The response was linear over the 0.2-6 microg/ml concentration range. Determination of the compound in oral dosage forms was achieved using the standard addition method. The average of determinations obtained by the squarewave adsorptive voltammetric method with its relative standard deviation was 99.8 +/- 2.40%. SN - 0031-7144 UR - https://www.unboundmedicine.com/medline/citation/15801671/Adsorptive_stripping_voltammetric_determination_of_ambroxol_ DB - PRIME DP - Unbound Medicine ER -