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Risk factors for gastro-oesophageal reflux disease symptoms: a community study.

Abstract

AIM

To examine the prevalence of gastro-oesophageal reflux disease symptoms and potential risk factors among community subjects.

METHODS

A questionnaire was sent to 4000 subjects, stratified by age, gender and ethnicity to be representative of the local population. Gastro-oesophageal reflux disease symptoms were defined as at least weekly heartburn or acid regurgitation.

RESULTS

2231 responded (59%), 691 refused to participate and seven were incomplete. 1533 (41%) were evaluable (637 male, mean age 51 years, range: 20-80). The prevalence of gastro-oesophageal reflux disease symptoms was 21%. Smoking, excess alcohol, irritable bowel syndrome, increasing body mass index, a family history of upper gastrointestinal disease, increasing Townsend deprivation index, anticholinergic drugs (all P < 0.0001), weight gain, antidepressant drugs, inhaled bronchodilators, no educational attainment (all P < 0.01), south Asian origin (P = 0.02) and manual work (P < 0.05) were associated with gastro-oesophageal reflux disease symptoms. Multivariate logistic regression revealed increasing body mass index, a family history of upper gastrointestinal disease, irritable bowel syndrome, south Asian origin (all P < 0.0001), smoking, excess alcohol, no educational attainment and anticholinergic drugs (all P < 0.01) were independently associated with gastro-oesophageal reflux disease symptoms.

CONCLUSIONS

Frequent gastro-oesophageal reflux disease symptoms affect 21% of the population. Increasing body mass index, a family history of upper gastrointestinal disease, irritable bowel syndrome, south Asian origin, smoking, excess alcohol, social deprivation and anticholinergic drugs are independently associated with gastro-oesophageal reflux disease symptoms.

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  • Authors+Show Affiliations

    ,

    Department of Gastroenterology, Sandwell General Hospital, West Bromwich B71 4HJ, UK.

    ,

    Source

    Alimentary pharmacology & therapeutics 21:7 2005 Apr 01 pg 821-7

    MeSH

    Adult
    Aged
    Aged, 80 and over
    England
    Female
    Gastroesophageal Reflux
    Humans
    Male
    Middle Aged
    Multivariate Analysis
    Odds Ratio
    Prevalence
    Risk Factors
    Sex Distribution

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    15801917

    Citation

    Mohammed, I, et al. "Risk Factors for Gastro-oesophageal Reflux Disease Symptoms: a Community Study." Alimentary Pharmacology & Therapeutics, vol. 21, no. 7, 2005, pp. 821-7.
    Mohammed I, Nightingale P, Trudgill NJ. Risk factors for gastro-oesophageal reflux disease symptoms: a community study. Aliment Pharmacol Ther. 2005;21(7):821-7.
    Mohammed, I., Nightingale, P., & Trudgill, N. J. (2005). Risk factors for gastro-oesophageal reflux disease symptoms: a community study. Alimentary Pharmacology & Therapeutics, 21(7), pp. 821-7.
    Mohammed I, Nightingale P, Trudgill NJ. Risk Factors for Gastro-oesophageal Reflux Disease Symptoms: a Community Study. Aliment Pharmacol Ther. 2005 Apr 1;21(7):821-7. PubMed PMID: 15801917.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Risk factors for gastro-oesophageal reflux disease symptoms: a community study. AU - Mohammed,I, AU - Nightingale,P, AU - Trudgill,N J, PY - 2005/4/2/pubmed PY - 2005/8/2/medline PY - 2005/4/2/entrez SP - 821 EP - 7 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 21 IS - 7 N2 - AIM: To examine the prevalence of gastro-oesophageal reflux disease symptoms and potential risk factors among community subjects. METHODS: A questionnaire was sent to 4000 subjects, stratified by age, gender and ethnicity to be representative of the local population. Gastro-oesophageal reflux disease symptoms were defined as at least weekly heartburn or acid regurgitation. RESULTS: 2231 responded (59%), 691 refused to participate and seven were incomplete. 1533 (41%) were evaluable (637 male, mean age 51 years, range: 20-80). The prevalence of gastro-oesophageal reflux disease symptoms was 21%. Smoking, excess alcohol, irritable bowel syndrome, increasing body mass index, a family history of upper gastrointestinal disease, increasing Townsend deprivation index, anticholinergic drugs (all P < 0.0001), weight gain, antidepressant drugs, inhaled bronchodilators, no educational attainment (all P < 0.01), south Asian origin (P = 0.02) and manual work (P < 0.05) were associated with gastro-oesophageal reflux disease symptoms. Multivariate logistic regression revealed increasing body mass index, a family history of upper gastrointestinal disease, irritable bowel syndrome, south Asian origin (all P < 0.0001), smoking, excess alcohol, no educational attainment and anticholinergic drugs (all P < 0.01) were independently associated with gastro-oesophageal reflux disease symptoms. CONCLUSIONS: Frequent gastro-oesophageal reflux disease symptoms affect 21% of the population. Increasing body mass index, a family history of upper gastrointestinal disease, irritable bowel syndrome, south Asian origin, smoking, excess alcohol, social deprivation and anticholinergic drugs are independently associated with gastro-oesophageal reflux disease symptoms. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15801917/Risk_factors_for_gastro_oesophageal_reflux_disease_symptoms:_a_community_study_ L2 - https://doi.org/10.1111/j.1365-2036.2005.02426.x DB - PRIME DP - Unbound Medicine ER -