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Risk factors for gastro-oesophageal reflux disease symptoms: a community study.
Aliment Pharmacol Ther 2005; 21(7):821-7AP

Abstract

AIM

To examine the prevalence of gastro-oesophageal reflux disease symptoms and potential risk factors among community subjects.

METHODS

A questionnaire was sent to 4000 subjects, stratified by age, gender and ethnicity to be representative of the local population. Gastro-oesophageal reflux disease symptoms were defined as at least weekly heartburn or acid regurgitation.

RESULTS

2231 responded (59%), 691 refused to participate and seven were incomplete. 1533 (41%) were evaluable (637 male, mean age 51 years, range: 20-80). The prevalence of gastro-oesophageal reflux disease symptoms was 21%. Smoking, excess alcohol, irritable bowel syndrome, increasing body mass index, a family history of upper gastrointestinal disease, increasing Townsend deprivation index, anticholinergic drugs (all P < 0.0001), weight gain, antidepressant drugs, inhaled bronchodilators, no educational attainment (all P < 0.01), south Asian origin (P = 0.02) and manual work (P < 0.05) were associated with gastro-oesophageal reflux disease symptoms. Multivariate logistic regression revealed increasing body mass index, a family history of upper gastrointestinal disease, irritable bowel syndrome, south Asian origin (all P < 0.0001), smoking, excess alcohol, no educational attainment and anticholinergic drugs (all P < 0.01) were independently associated with gastro-oesophageal reflux disease symptoms.

CONCLUSIONS

Frequent gastro-oesophageal reflux disease symptoms affect 21% of the population. Increasing body mass index, a family history of upper gastrointestinal disease, irritable bowel syndrome, south Asian origin, smoking, excess alcohol, social deprivation and anticholinergic drugs are independently associated with gastro-oesophageal reflux disease symptoms.

Authors+Show Affiliations

Department of Gastroenterology, Sandwell General Hospital, West Bromwich B71 4HJ, UK.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15801917

Citation

Mohammed, I, et al. "Risk Factors for Gastro-oesophageal Reflux Disease Symptoms: a Community Study." Alimentary Pharmacology & Therapeutics, vol. 21, no. 7, 2005, pp. 821-7.
Mohammed I, Nightingale P, Trudgill NJ. Risk factors for gastro-oesophageal reflux disease symptoms: a community study. Aliment Pharmacol Ther. 2005;21(7):821-7.
Mohammed, I., Nightingale, P., & Trudgill, N. J. (2005). Risk factors for gastro-oesophageal reflux disease symptoms: a community study. Alimentary Pharmacology & Therapeutics, 21(7), pp. 821-7.
Mohammed I, Nightingale P, Trudgill NJ. Risk Factors for Gastro-oesophageal Reflux Disease Symptoms: a Community Study. Aliment Pharmacol Ther. 2005 Apr 1;21(7):821-7. PubMed PMID: 15801917.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Risk factors for gastro-oesophageal reflux disease symptoms: a community study. AU - Mohammed,I, AU - Nightingale,P, AU - Trudgill,N J, PY - 2005/4/2/pubmed PY - 2005/8/2/medline PY - 2005/4/2/entrez SP - 821 EP - 7 JF - Alimentary pharmacology & therapeutics JO - Aliment. Pharmacol. Ther. VL - 21 IS - 7 N2 - AIM: To examine the prevalence of gastro-oesophageal reflux disease symptoms and potential risk factors among community subjects. METHODS: A questionnaire was sent to 4000 subjects, stratified by age, gender and ethnicity to be representative of the local population. Gastro-oesophageal reflux disease symptoms were defined as at least weekly heartburn or acid regurgitation. RESULTS: 2231 responded (59%), 691 refused to participate and seven were incomplete. 1533 (41%) were evaluable (637 male, mean age 51 years, range: 20-80). The prevalence of gastro-oesophageal reflux disease symptoms was 21%. Smoking, excess alcohol, irritable bowel syndrome, increasing body mass index, a family history of upper gastrointestinal disease, increasing Townsend deprivation index, anticholinergic drugs (all P < 0.0001), weight gain, antidepressant drugs, inhaled bronchodilators, no educational attainment (all P < 0.01), south Asian origin (P = 0.02) and manual work (P < 0.05) were associated with gastro-oesophageal reflux disease symptoms. Multivariate logistic regression revealed increasing body mass index, a family history of upper gastrointestinal disease, irritable bowel syndrome, south Asian origin (all P < 0.0001), smoking, excess alcohol, no educational attainment and anticholinergic drugs (all P < 0.01) were independently associated with gastro-oesophageal reflux disease symptoms. CONCLUSIONS: Frequent gastro-oesophageal reflux disease symptoms affect 21% of the population. Increasing body mass index, a family history of upper gastrointestinal disease, irritable bowel syndrome, south Asian origin, smoking, excess alcohol, social deprivation and anticholinergic drugs are independently associated with gastro-oesophageal reflux disease symptoms. SN - 0269-2813 UR - https://www.unboundmedicine.com/medline/citation/15801917/Risk_factors_for_gastro_oesophageal_reflux_disease_symptoms:_a_community_study_ L2 - https://doi.org/10.1111/j.1365-2036.2005.02426.x DB - PRIME DP - Unbound Medicine ER -