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Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB.
Biol Pharm Bull 2005; 28(4):607-10BP

Abstract

Transcription factor nuclear factor-kappa B (NF-kappaB) has been demonstrated to be important in regulating various gene expressions such as cytokines, adhesion molecules, and endothelin-1 (ET-1) in vascular endothelial cells. In the present study, we show the effects of xanthoangelol, xanthoangelol D, E, and F, which isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae), on NF-kappaB activation and ET-1 gene expression in cultured porcine aortic endothelial cells (PAECs). Treatments of xanthoangelol D but not xanthoangelol, xanthoangelol E and F markedly suppressed both of basal and tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation in PAECs. To clarify the mechanism of xanthoangelol D-induced suppression on NF-kappaB activation, we evaluated the effects of xanthoangelol D on phosphorylation and degradation of IkappaBalpha, an inhibitory protein bound to NF-kappaB, and obtained evidence that xanthoangelol D selectively suppresses the phosphorylation of IkappaBalpha rather than the degradation of phosphorylated IkappaBalpha. In addition, xanthoangelol D significantly attenuated basal and TNF-alpha-induced prepro ET-1 mRNA expression in PAECs. These results suggest that xanthoangelol D may be useful for the treatment of various vascular diseases involved NF-kappaB activation.

Authors+Show Affiliations

Department of Pharmacology, Osaka University of Pharmaceutical Sciences, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15802795

Citation

Sugii, Masato, et al. "Xanthoangelol D Isolated From the Roots of Angelica Keiskei Inhibits Endothelin-1 Production Through the Suppression of Nuclear Factor-kappaB." Biological & Pharmaceutical Bulletin, vol. 28, no. 4, 2005, pp. 607-10.
Sugii M, Ohkita M, Taniguchi M, et al. Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB. Biol Pharm Bull. 2005;28(4):607-10.
Sugii, M., Ohkita, M., Taniguchi, M., Baba, K., Kawai, Y., Tahara, C., ... Matsumura, Y. (2005). Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB. Biological & Pharmaceutical Bulletin, 28(4), pp. 607-10.
Sugii M, et al. Xanthoangelol D Isolated From the Roots of Angelica Keiskei Inhibits Endothelin-1 Production Through the Suppression of Nuclear Factor-kappaB. Biol Pharm Bull. 2005;28(4):607-10. PubMed PMID: 15802795.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Xanthoangelol D isolated from the roots of Angelica keiskei inhibits endothelin-1 production through the suppression of nuclear factor-kappaB. AU - Sugii,Masato, AU - Ohkita,Mamoru, AU - Taniguchi,Masahiko, AU - Baba,Kimiye, AU - Kawai,Yu, AU - Tahara,Chiyoko, AU - Takaoka,Masanori, AU - Matsumura,Yasuo, PY - 2005/4/2/pubmed PY - 2005/8/27/medline PY - 2005/4/2/entrez SP - 607 EP - 10 JF - Biological & pharmaceutical bulletin JO - Biol. Pharm. Bull. VL - 28 IS - 4 N2 - Transcription factor nuclear factor-kappa B (NF-kappaB) has been demonstrated to be important in regulating various gene expressions such as cytokines, adhesion molecules, and endothelin-1 (ET-1) in vascular endothelial cells. In the present study, we show the effects of xanthoangelol, xanthoangelol D, E, and F, which isolated from the root of Angelica keiskei KOIDZUMI (Umbelliferae), on NF-kappaB activation and ET-1 gene expression in cultured porcine aortic endothelial cells (PAECs). Treatments of xanthoangelol D but not xanthoangelol, xanthoangelol E and F markedly suppressed both of basal and tumor necrosis factor-alpha (TNF-alpha)-induced NF-kappaB activation in PAECs. To clarify the mechanism of xanthoangelol D-induced suppression on NF-kappaB activation, we evaluated the effects of xanthoangelol D on phosphorylation and degradation of IkappaBalpha, an inhibitory protein bound to NF-kappaB, and obtained evidence that xanthoangelol D selectively suppresses the phosphorylation of IkappaBalpha rather than the degradation of phosphorylated IkappaBalpha. In addition, xanthoangelol D significantly attenuated basal and TNF-alpha-induced prepro ET-1 mRNA expression in PAECs. These results suggest that xanthoangelol D may be useful for the treatment of various vascular diseases involved NF-kappaB activation. SN - 0918-6158 UR - https://www.unboundmedicine.com/medline/citation/15802795/Xanthoangelol_D_isolated_from_the_roots_of_Angelica_keiskei_inhibits_endothelin_1_production_through_the_suppression_of_nuclear_factor_kappaB_ L2 - http://joi.jlc.jst.go.jp/JST.JSTAGE/bpb/28.607?from=PubMed DB - PRIME DP - Unbound Medicine ER -