Tags

Type your tag names separated by a space and hit enter

A randomized clinical trial with oral Immunonutrition (omega3-enhanced formula vs. arginine-enhanced formula) in ambulatory head and neck cancer patients.
Ann Nutr Metab 2005 Mar-Apr; 49(2):95-9AN

Abstract

OBJECTIVE

The aim of our study was to investigate whether oral ambulatory nutrition of head and neck cancer patients, using an omega3 fatty acid-enhanced diet (low ratio omega6/omega3 fatty acids) versus an arginine-enhanced diet, could improve nutritional variables as well as clinical outcome, postoperative infectious and wound complications.

RESEARCH METHODS

A population of 73 ambulatory postsurgical patients with oral and laryngeal cancer were enrolled. At discharge from hospital the postsurgical head and neck cancer patients were asked to consume two units per day of either a specially designed omega3 fatty acid-enhanced supplement (group 1) or an arginine-enhanced supplement (group 2) for a 12-week period.

RESULTS

No significant intergroup differences in the trend of the three serum proteins and lymphocytes were detected. Differences were detected in weight (group 1: 65.5 +/- 11.5 kg vs. 70.4 +/- 11.1 kg; p < 0.05) with a significant increase in fat mass in group 1 (15.4 +/- 6.6 vs. 18.1 +/- 8.4 kg; p < 0.05) and in tricipital skinfold. The postoperative infectious complications were similar in both groups (0 in group 1 and 8.57% in group 2; nonsignificant). No local complications were detected in the surgical wound. Gastrointestinal tolerance (diarrhea and vomiting episodes) of both formulas was good.

CONCLUSIONS

At the dose taken, the omega3-enhanced formula improved fat mass and proteins in ambulatory postoperative head and neck cancer patients. The arginine-enhanced formula improved proteins. Further studies are required to examine the potential role of immune-enhanced supplements.

Authors+Show Affiliations

Institute of Endocrinology and Nutrition, Medicine School and Unit of Investigation, Hospital Rio Hortega, Valladolid, Spain. dadlius@yahoo.esNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15802904

Citation

de Luis, D A., et al. "A Randomized Clinical Trial With Oral Immunonutrition (omega3-enhanced Formula Vs. Arginine-enhanced Formula) in Ambulatory Head and Neck Cancer Patients." Annals of Nutrition & Metabolism, vol. 49, no. 2, 2005, pp. 95-9.
de Luis DA, Izaola O, Aller R, et al. A randomized clinical trial with oral Immunonutrition (omega3-enhanced formula vs. arginine-enhanced formula) in ambulatory head and neck cancer patients. Ann Nutr Metab. 2005;49(2):95-9.
de Luis, D. A., Izaola, O., Aller, R., Cuellar, L., & Terroba, M. C. (2005). A randomized clinical trial with oral Immunonutrition (omega3-enhanced formula vs. arginine-enhanced formula) in ambulatory head and neck cancer patients. Annals of Nutrition & Metabolism, 49(2), pp. 95-9.
de Luis DA, et al. A Randomized Clinical Trial With Oral Immunonutrition (omega3-enhanced Formula Vs. Arginine-enhanced Formula) in Ambulatory Head and Neck Cancer Patients. Ann Nutr Metab. 2005;49(2):95-9. PubMed PMID: 15802904.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A randomized clinical trial with oral Immunonutrition (omega3-enhanced formula vs. arginine-enhanced formula) in ambulatory head and neck cancer patients. AU - de Luis,D A, AU - Izaola,O, AU - Aller,R, AU - Cuellar,L, AU - Terroba,M C, Y1 - 2005/03/29/ PY - 2004/07/27/received PY - 2004/11/09/accepted PY - 2005/4/2/pubmed PY - 2005/10/29/medline PY - 2005/4/2/entrez SP - 95 EP - 9 JF - Annals of nutrition & metabolism JO - Ann. Nutr. Metab. VL - 49 IS - 2 N2 - OBJECTIVE: The aim of our study was to investigate whether oral ambulatory nutrition of head and neck cancer patients, using an omega3 fatty acid-enhanced diet (low ratio omega6/omega3 fatty acids) versus an arginine-enhanced diet, could improve nutritional variables as well as clinical outcome, postoperative infectious and wound complications. RESEARCH METHODS: A population of 73 ambulatory postsurgical patients with oral and laryngeal cancer were enrolled. At discharge from hospital the postsurgical head and neck cancer patients were asked to consume two units per day of either a specially designed omega3 fatty acid-enhanced supplement (group 1) or an arginine-enhanced supplement (group 2) for a 12-week period. RESULTS: No significant intergroup differences in the trend of the three serum proteins and lymphocytes were detected. Differences were detected in weight (group 1: 65.5 +/- 11.5 kg vs. 70.4 +/- 11.1 kg; p < 0.05) with a significant increase in fat mass in group 1 (15.4 +/- 6.6 vs. 18.1 +/- 8.4 kg; p < 0.05) and in tricipital skinfold. The postoperative infectious complications were similar in both groups (0 in group 1 and 8.57% in group 2; nonsignificant). No local complications were detected in the surgical wound. Gastrointestinal tolerance (diarrhea and vomiting episodes) of both formulas was good. CONCLUSIONS: At the dose taken, the omega3-enhanced formula improved fat mass and proteins in ambulatory postoperative head and neck cancer patients. The arginine-enhanced formula improved proteins. Further studies are required to examine the potential role of immune-enhanced supplements. SN - 0250-6807 UR - https://www.unboundmedicine.com/medline/citation/15802904/A_randomized_clinical_trial_with_oral_Immunonutrition__omega3_enhanced_formula_vs__arginine_enhanced_formula__in_ambulatory_head_and_neck_cancer_patients_ L2 - https://www.karger.com?DOI=10.1159/000084742 DB - PRIME DP - Unbound Medicine ER -