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[Serum soluble CD40L level and its application in coronary heart disease].
Hunan Yi Ke Da Xue Xue Bao 2003; 28(6):611-4HY

Abstract

OBJECTIVE

To investigate the serum level of soluble CD40 ligand (sCD40L) in coronary heart disease and its relationship with serum lipid levels.

METHODS

Enzyme-linked immunosorbent (EIA) was used to measure sCD40L in 129 patients with coronary heart disease (46 with acute myocardial infarction, 37 with unstable angina pectoris and the other 46 with stable angina pectoris) and 30 matched healthy controls.

RESULTS

sCD40L level was significantly higher in patients with acute coronary syndrome (ACS) [(2. 99 +/- 2.19), (2.23 +/- 0.67) ng/ml in acute myocardial infarction and unstable angina pectoris group, respectively] than that of those with stable coronary heart disease and that of controls [(1.12 +/- 0.42) and (0.89 +/- 0.55) ng/ml, respectively] (P < 0.05). Serum sCD40L level was significantly positively related to ApoB100 (r = 0.159, P = 0.046), and negatively related to HDL-C (r = -0.192, P = 0.015).

CONCLUSION

The levels of sCD40L increase in acute coronary syndrome, which may be related to the pathogenesis of ACS, and can be used as a potential marker of plaque instability.

Authors+Show Affiliations

Department of Cardiology, Second Xiangya Hospital, Central South University, Changsha 410011, China.No affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article

Language

chi

PubMed ID

15804073

Citation

Li, Jiang, et al. "[Serum Soluble CD40L Level and Its Application in Coronary Heart Disease]." Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, vol. 28, no. 6, 2003, pp. 611-4.
Li J, Peng DQ, Zhao SP. [Serum soluble CD40L level and its application in coronary heart disease]. Hunan Yi Ke Da Xue Xue Bao. 2003;28(6):611-4.
Li, J., Peng, D. Q., & Zhao, S. P. (2003). [Serum soluble CD40L level and its application in coronary heart disease]. Hunan Yi Ke Da Xue Xue Bao = Hunan Yike Daxue Xuebao = Bulletin of Hunan Medical University, 28(6), pp. 611-4.
Li J, Peng DQ, Zhao SP. [Serum Soluble CD40L Level and Its Application in Coronary Heart Disease]. Hunan Yi Ke Da Xue Xue Bao. 2003;28(6):611-4. PubMed PMID: 15804073.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Serum soluble CD40L level and its application in coronary heart disease]. AU - Li,Jiang, AU - Peng,Dao-quan, AU - Zhao,Shui-ping, PY - 2005/4/5/pubmed PY - 2006/4/28/medline PY - 2005/4/5/entrez SP - 611 EP - 4 JF - Hunan yi ke da xue xue bao = Hunan yike daxue xuebao = Bulletin of Hunan Medical University JO - Hunan Yi Ke Da Xue Xue Bao VL - 28 IS - 6 N2 - OBJECTIVE: To investigate the serum level of soluble CD40 ligand (sCD40L) in coronary heart disease and its relationship with serum lipid levels. METHODS: Enzyme-linked immunosorbent (EIA) was used to measure sCD40L in 129 patients with coronary heart disease (46 with acute myocardial infarction, 37 with unstable angina pectoris and the other 46 with stable angina pectoris) and 30 matched healthy controls. RESULTS: sCD40L level was significantly higher in patients with acute coronary syndrome (ACS) [(2. 99 +/- 2.19), (2.23 +/- 0.67) ng/ml in acute myocardial infarction and unstable angina pectoris group, respectively] than that of those with stable coronary heart disease and that of controls [(1.12 +/- 0.42) and (0.89 +/- 0.55) ng/ml, respectively] (P < 0.05). Serum sCD40L level was significantly positively related to ApoB100 (r = 0.159, P = 0.046), and negatively related to HDL-C (r = -0.192, P = 0.015). CONCLUSION: The levels of sCD40L increase in acute coronary syndrome, which may be related to the pathogenesis of ACS, and can be used as a potential marker of plaque instability. SN - 1000-5625 UR - https://www.unboundmedicine.com/medline/citation/15804073/[Serum_soluble_CD40L_level_and_its_application_in_coronary_heart_disease]_ L2 - http://www.diseaseinfosearch.org/result/130 DB - PRIME DP - Unbound Medicine ER -