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Two cases of "cannabis acute psychosis" following the administration of oral cannabis.
BMC Psychiatry. 2005 Apr 01; 5:17.BP

Abstract

BACKGROUND

Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions have been described but not clearly with synthetic oral THC, especially in occasional users.

CASE PRESENTATIONS

We report two cases of healthy subjects who were occasional but regular cannabis users without psychiatric history who developed transient psychotic symptoms (depersonalization, paranoid feelings and derealisation) following oral administration of cannabis. In contrast to most other case reports where circumstances and blood concentrations are unknown, the two cases reported here happened under experimental conditions with all subjects negative for cannabis, opiates, amphetamines, cocaine, benzodiazepines and alcohol, and therefore the ingested dose, the time-events of effects on behavior and performance as well as the cannabinoid blood levels were documented.

CONCLUSION

While the oral route of administration achieves only limited blood concentrations, significant psychotic reactions may occur.

Authors+Show Affiliations

Unité de Médecine du Trafic, Institut Universitaire de Médecine Légale, 1005 Lausanne, Switzerland. bernard.favrat@hospvd.chNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15804348

Citation

Favrat, Bernard, et al. "Two Cases of "cannabis Acute Psychosis" Following the Administration of Oral Cannabis." BMC Psychiatry, vol. 5, 2005, p. 17.
Favrat B, Ménétrey A, Augsburger M, et al. Two cases of "cannabis acute psychosis" following the administration of oral cannabis. BMC Psychiatry. 2005;5:17.
Favrat, B., Ménétrey, A., Augsburger, M., Rothuizen, L. E., Appenzeller, M., Buclin, T., Pin, M., Mangin, P., & Giroud, C. (2005). Two cases of "cannabis acute psychosis" following the administration of oral cannabis. BMC Psychiatry, 5, 17.
Favrat B, et al. Two Cases of "cannabis Acute Psychosis" Following the Administration of Oral Cannabis. BMC Psychiatry. 2005 Apr 1;5:17. PubMed PMID: 15804348.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Two cases of "cannabis acute psychosis" following the administration of oral cannabis. AU - Favrat,Bernard, AU - Ménétrey,Annick, AU - Augsburger,Marc, AU - Rothuizen,Laura E, AU - Appenzeller,Monique, AU - Buclin,Thierry, AU - Pin,Marie, AU - Mangin,Patrice, AU - Giroud,Christian, Y1 - 2005/04/01/ PY - 2005/01/21/received PY - 2005/04/01/accepted PY - 2005/4/5/pubmed PY - 2006/7/28/medline PY - 2005/4/5/entrez SP - 17 EP - 17 JF - BMC psychiatry JO - BMC Psychiatry VL - 5 N2 - BACKGROUND: Cannabis is the most commonly used illegal drug and its therapeutic aspects have a growing interest. Short-term psychotic reactions have been described but not clearly with synthetic oral THC, especially in occasional users. CASE PRESENTATIONS: We report two cases of healthy subjects who were occasional but regular cannabis users without psychiatric history who developed transient psychotic symptoms (depersonalization, paranoid feelings and derealisation) following oral administration of cannabis. In contrast to most other case reports where circumstances and blood concentrations are unknown, the two cases reported here happened under experimental conditions with all subjects negative for cannabis, opiates, amphetamines, cocaine, benzodiazepines and alcohol, and therefore the ingested dose, the time-events of effects on behavior and performance as well as the cannabinoid blood levels were documented. CONCLUSION: While the oral route of administration achieves only limited blood concentrations, significant psychotic reactions may occur. SN - 1471-244X UR - https://www.unboundmedicine.com/medline/citation/15804348/Two_cases_of_"cannabis_acute_psychosis"_following_the_administration_of_oral_cannabis_ L2 - https://bmcpsychiatry.biomedcentral.com/articles/10.1186/1471-244X-5-17 DB - PRIME DP - Unbound Medicine ER -