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Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trials.

Abstract

OBJECTIVE

To evaluate the effectiveness of multivitamins and mineral supplements in reducing infections in an elderly population.

DESIGN

Systematic review and meta-analysis of randomised controlled trials.

DATA SOURCES

Medline and other databases. Reference lists of identified articles were inspected for further relevant articles.

SELECTION OF STUDIES

Trials were included if they evaluated the effect of multivitamins and mineral supplements on infections in an elderly population.

REVIEW METHODS

Studies were assessed for the methodological quality by using the Jadad instrument. If the data required for the analyses were not available from the published articles we requested them from the original study authors. Meta-analysis was undertaken on three outcomes: the mean difference in number of days spent with infection, the odds ratio of at least one infection in the study period, and the incidence rate ratio for the difference in infection rates. Data on adverse events were also extracted.

RESULTS

Eight trials met our inclusion criteria. Owing to inconsistency in the outcomes reported, only a proportion of the trials could be included in each meta-analysis. Multivitamins and mineral supplements were found to reduce the mean annual number of days spent with infection (three studies) by 17.5 (95% confidence interval 11 to 24, P < 0.001). The odds ratio for at least one infection in the study period (three studies) was 1.10 (0.81 to 1.50, P = 0.53). The infection rate ratio (four studies) was 0.89 (0.78 to 1.03, P = 0.11). Reporting of adverse events was poor.

CONCLUSION

The evidence for routine use of multivitamin and mineral supplements to reduce infections in elderly people is weak and conflicting. Study results are heterogeneous, and this is partially confounded by outcome measure.

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  • Authors+Show Affiliations

    ,

    Chemical Pathology Department, Royal Hallamshire Hospital, Sheffield S10 2JF. alia@elkadiki.fsnet.co.uk

    Source

    BMJ (Clinical research ed.) 330:7496 2005 Apr 16 pg 871

    MeSH

    Aged
    Dietary Supplements
    Humans
    Infection Control
    Minerals
    Randomized Controlled Trials as Topic
    Treatment Outcome
    Vitamins

    Pub Type(s)

    Journal Article
    Meta-Analysis
    Review
    Systematic Review

    Language

    eng

    PubMed ID

    15805125

    Citation

    El-Kadiki, Alia, and Alexander J. Sutton. "Role of Multivitamins and Mineral Supplements in Preventing Infections in Elderly People: Systematic Review and Meta-analysis of Randomised Controlled Trials." BMJ (Clinical Research Ed.), vol. 330, no. 7496, 2005, p. 871.
    El-Kadiki A, Sutton AJ. Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trials. BMJ. 2005;330(7496):871.
    El-Kadiki, A., & Sutton, A. J. (2005). Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trials. BMJ (Clinical Research Ed.), 330(7496), p. 871.
    El-Kadiki A, Sutton AJ. Role of Multivitamins and Mineral Supplements in Preventing Infections in Elderly People: Systematic Review and Meta-analysis of Randomised Controlled Trials. BMJ. 2005 Apr 16;330(7496):871. PubMed PMID: 15805125.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Role of multivitamins and mineral supplements in preventing infections in elderly people: systematic review and meta-analysis of randomised controlled trials. AU - El-Kadiki,Alia, AU - Sutton,Alexander J, Y1 - 2005/03/31/ PY - 2005/4/5/pubmed PY - 2005/4/27/medline PY - 2005/4/5/entrez SP - 871 EP - 871 JF - BMJ (Clinical research ed.) JO - BMJ VL - 330 IS - 7496 N2 - OBJECTIVE: To evaluate the effectiveness of multivitamins and mineral supplements in reducing infections in an elderly population. DESIGN: Systematic review and meta-analysis of randomised controlled trials. DATA SOURCES: Medline and other databases. Reference lists of identified articles were inspected for further relevant articles. SELECTION OF STUDIES: Trials were included if they evaluated the effect of multivitamins and mineral supplements on infections in an elderly population. REVIEW METHODS: Studies were assessed for the methodological quality by using the Jadad instrument. If the data required for the analyses were not available from the published articles we requested them from the original study authors. Meta-analysis was undertaken on three outcomes: the mean difference in number of days spent with infection, the odds ratio of at least one infection in the study period, and the incidence rate ratio for the difference in infection rates. Data on adverse events were also extracted. RESULTS: Eight trials met our inclusion criteria. Owing to inconsistency in the outcomes reported, only a proportion of the trials could be included in each meta-analysis. Multivitamins and mineral supplements were found to reduce the mean annual number of days spent with infection (three studies) by 17.5 (95% confidence interval 11 to 24, P < 0.001). The odds ratio for at least one infection in the study period (three studies) was 1.10 (0.81 to 1.50, P = 0.53). The infection rate ratio (four studies) was 0.89 (0.78 to 1.03, P = 0.11). Reporting of adverse events was poor. CONCLUSION: The evidence for routine use of multivitamin and mineral supplements to reduce infections in elderly people is weak and conflicting. Study results are heterogeneous, and this is partially confounded by outcome measure. SN - 1756-1833 UR - https://www.unboundmedicine.com/medline/citation/15805125/full_citation L2 - http://www.bmj.com/cgi/pmidlookup?view=long&amp;pmid=15805125 DB - PRIME DP - Unbound Medicine ER -