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Chronic kidney disease as a metabolic syndrome with malnutrition--need for strict control of risk factors.
Intern Med 2005; 44(3):179-87IM

Abstract

Patients with chronic kidney disease (CKD) have an increased risk for death from cardiovascular disease (CVD). They have multiple metabolic abnormalities that may accelerate atherosclerosis, such as hypertension, insulin resistance, and dyslipidemia, along with other CKD-related risk factors. In addition, a considerable proportion of patients with advanced stages of CKD are malnourished, presenting "metabolic syndrome with malnutrition". The presence of malnutrition/inflammation dramatically changes the apparent relationship between CVD death risk and some risk factors. For example, in stage 5 CKD patients on hemodialysis, a higher body mass index and a higher plasma cholesterol are predictors of better survival. To understand the paradoxic epidemiology, we should recognize risk factors for occurrence of CVD events and risk factors of fatality after an event. In this article, we review the unique situation of CKD, emphasizing the need of more strict control of both types of risk factors to improve survival of CKD patients.

Authors+Show Affiliations

Department of Metabolism, Endocrinology and Molecular Medicine, Osaka City University Graduate School of Medicine, Abeno-ku, Osaka 545-8585.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

15805704

Citation

Shoji, Tetsuo, and Yoshiki Nishizawa. "Chronic Kidney Disease as a Metabolic Syndrome With Malnutrition--need for Strict Control of Risk Factors." Internal Medicine (Tokyo, Japan), vol. 44, no. 3, 2005, pp. 179-87.
Shoji T, Nishizawa Y. Chronic kidney disease as a metabolic syndrome with malnutrition--need for strict control of risk factors. Intern Med. 2005;44(3):179-87.
Shoji, T., & Nishizawa, Y. (2005). Chronic kidney disease as a metabolic syndrome with malnutrition--need for strict control of risk factors. Internal Medicine (Tokyo, Japan), 44(3), pp. 179-87.
Shoji T, Nishizawa Y. Chronic Kidney Disease as a Metabolic Syndrome With Malnutrition--need for Strict Control of Risk Factors. Intern Med. 2005;44(3):179-87. PubMed PMID: 15805704.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Chronic kidney disease as a metabolic syndrome with malnutrition--need for strict control of risk factors. AU - Shoji,Tetsuo, AU - Nishizawa,Yoshiki, PY - 2005/4/5/pubmed PY - 2005/7/1/medline PY - 2005/4/5/entrez SP - 179 EP - 87 JF - Internal medicine (Tokyo, Japan) JO - Intern. Med. VL - 44 IS - 3 N2 - Patients with chronic kidney disease (CKD) have an increased risk for death from cardiovascular disease (CVD). They have multiple metabolic abnormalities that may accelerate atherosclerosis, such as hypertension, insulin resistance, and dyslipidemia, along with other CKD-related risk factors. In addition, a considerable proportion of patients with advanced stages of CKD are malnourished, presenting "metabolic syndrome with malnutrition". The presence of malnutrition/inflammation dramatically changes the apparent relationship between CVD death risk and some risk factors. For example, in stage 5 CKD patients on hemodialysis, a higher body mass index and a higher plasma cholesterol are predictors of better survival. To understand the paradoxic epidemiology, we should recognize risk factors for occurrence of CVD events and risk factors of fatality after an event. In this article, we review the unique situation of CKD, emphasizing the need of more strict control of both types of risk factors to improve survival of CKD patients. SN - 0918-2918 UR - https://www.unboundmedicine.com/medline/citation/15805704/full_citation L2 - https://joi.jlc.jst.go.jp/JST.JSTAGE/internalmedicine/44.179?from=PubMed DB - PRIME DP - Unbound Medicine ER -