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Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus.
Otolaryngol Head Neck Surg. 2005 Apr; 132(4):566-9.OH

Abstract

OBJECTIVES

The pathophysiologic mechanisms of idiopathic tinnitus remain unclear. Recent studies demonstrated focal brain activation in the auditory cortex of patients with chronic tinnitus. Low-frequency repetitive transcranial magnetic stimulation (rTMS) is able to reduce cortical hyperexcitability.

STUDY DESIGN

Fusing of the individual PET-scan with the structural MRI-scan (T1, MPRAGE) allowed us to identify exactly the area of increased metabolic activity in the auditory cortex of patients with chronic tinnitus. With the use of a neuronavigational system, this target area was exactly stimulated by the figure 8-shaped magnetic coil. In a prospective study, rTMS (110% motor threshold; 1 Hz; 2000 stimuli/day over 5 days) was performed using a placebo controlled cross-over design. Patients were blinded regarding the stimulus condition. For the sham stimulation a specific sham-coil system was used. Fourteen patients were followed for 6 months. Treatment outcome was assessed with a specific tinnitus questionnaire (Goebel and Hiller).

SETTING

Tertiary referral medical center.

RESULTS

Increased metabolic activation in the auditory cortex was verified in all patients. After 5 days of verum rTMS, a highly significant improvement of the tinnitus score was found whereas the sham treatment did not show any significant changes. The treatment outcome after 6 months still demonstrated significant reduction of tinnitus score.

CONCLUSION

These preliminary results demonstrate that neuronavigated rTMS offers new possibilities in the understanding and treatment of chronic tinnitus.

Authors+Show Affiliations

Department of Otorhinolaryngology, University of Regensburg, Germany. tobias.kleinjung@klinik.uni-regensburg.deNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15806046

Citation

Kleinjung, Tobias, et al. "Long-term Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Chronic Tinnitus." Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, vol. 132, no. 4, 2005, pp. 566-9.
Kleinjung T, Eichhammer P, Langguth B, et al. Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus. Otolaryngol Head Neck Surg. 2005;132(4):566-9.
Kleinjung, T., Eichhammer, P., Langguth, B., Jacob, P., Marienhagen, J., Hajak, G., Wolf, S. R., & Strutz, J. (2005). Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus. Otolaryngology--head and Neck Surgery : Official Journal of American Academy of Otolaryngology-Head and Neck Surgery, 132(4), 566-9.
Kleinjung T, et al. Long-term Effects of Repetitive Transcranial Magnetic Stimulation (rTMS) in Patients With Chronic Tinnitus. Otolaryngol Head Neck Surg. 2005;132(4):566-9. PubMed PMID: 15806046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term effects of repetitive transcranial magnetic stimulation (rTMS) in patients with chronic tinnitus. AU - Kleinjung,Tobias, AU - Eichhammer,Peter, AU - Langguth,Berthold, AU - Jacob,Peter, AU - Marienhagen,Joerg, AU - Hajak,Goeran, AU - Wolf,Stephan R, AU - Strutz,Juergen, PY - 2005/4/5/pubmed PY - 2005/4/30/medline PY - 2005/4/5/entrez SP - 566 EP - 9 JF - Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery JO - Otolaryngol Head Neck Surg VL - 132 IS - 4 N2 - OBJECTIVES: The pathophysiologic mechanisms of idiopathic tinnitus remain unclear. Recent studies demonstrated focal brain activation in the auditory cortex of patients with chronic tinnitus. Low-frequency repetitive transcranial magnetic stimulation (rTMS) is able to reduce cortical hyperexcitability. STUDY DESIGN: Fusing of the individual PET-scan with the structural MRI-scan (T1, MPRAGE) allowed us to identify exactly the area of increased metabolic activity in the auditory cortex of patients with chronic tinnitus. With the use of a neuronavigational system, this target area was exactly stimulated by the figure 8-shaped magnetic coil. In a prospective study, rTMS (110% motor threshold; 1 Hz; 2000 stimuli/day over 5 days) was performed using a placebo controlled cross-over design. Patients were blinded regarding the stimulus condition. For the sham stimulation a specific sham-coil system was used. Fourteen patients were followed for 6 months. Treatment outcome was assessed with a specific tinnitus questionnaire (Goebel and Hiller). SETTING: Tertiary referral medical center. RESULTS: Increased metabolic activation in the auditory cortex was verified in all patients. After 5 days of verum rTMS, a highly significant improvement of the tinnitus score was found whereas the sham treatment did not show any significant changes. The treatment outcome after 6 months still demonstrated significant reduction of tinnitus score. CONCLUSION: These preliminary results demonstrate that neuronavigated rTMS offers new possibilities in the understanding and treatment of chronic tinnitus. SN - 0194-5998 UR - https://www.unboundmedicine.com/medline/citation/15806046/Long_term_effects_of_repetitive_transcranial_magnetic_stimulation__rTMS__in_patients_with_chronic_tinnitus_ L2 - https://journals.sagepub.com/doi/10.1016/j.otohns.2004.09.134?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -