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An unusual presentation of secondary syphilis in a patient with human immunodeficiency virus infection. A case report and review of the literature.
Arch Dermatol. 1992 Apr; 128(4):530-4.AD

Abstract

BACKGROUND

Syphilis has been reported to assume unusual clinical appearances and to exhibit unusual courses in patients infected with the human immunodeficiency virus (HIV) type 1. We recently observed a distinct manifestation of syphilis in an HIV-infected patient with features not previously described.

OBSERVATIONS

A 38-year-old HIV-seropositive homosexual man presented with fever, chills, malaise, and a cutaneous eruption consisting of indurated, shiny, erythematous plaques that were confluent on the face and scalp leading to alopecia and extreme tautness of the skin. Initial clinical diagnoses included lymphoreticular malignancy and infection. Although cultures yielded Staphylococcus aureus, a skin biopsy specimen was diagnostic of syphilis.

CONCLUSIONS

This case demonstrates an unusual clinical manifestation of syphilis in a patient with HIV infection and emphasizes the importance of considering cutaneous secondary syphilis in the differential diagnosis of virtually any inflammatory cutaneous disorder in HIV-seropositive individuals.

Authors+Show Affiliations

Department of Dermatology, University of Texas Southwestern Medical Center, Dallas 75235-9072.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Review

Language

eng

PubMed ID

1580662

Citation

Glover, R A., et al. "An Unusual Presentation of Secondary Syphilis in a Patient With Human Immunodeficiency Virus Infection. a Case Report and Review of the Literature." Archives of Dermatology, vol. 128, no. 4, 1992, pp. 530-4.
Glover RA, Piaquadio DJ, Kern S, et al. An unusual presentation of secondary syphilis in a patient with human immunodeficiency virus infection. A case report and review of the literature. Arch Dermatol. 1992;128(4):530-4.
Glover, R. A., Piaquadio, D. J., Kern, S., & Cockerell, C. J. (1992). An unusual presentation of secondary syphilis in a patient with human immunodeficiency virus infection. A case report and review of the literature. Archives of Dermatology, 128(4), 530-4.
Glover RA, et al. An Unusual Presentation of Secondary Syphilis in a Patient With Human Immunodeficiency Virus Infection. a Case Report and Review of the Literature. Arch Dermatol. 1992;128(4):530-4. PubMed PMID: 1580662.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - An unusual presentation of secondary syphilis in a patient with human immunodeficiency virus infection. A case report and review of the literature. AU - Glover,R A, AU - Piaquadio,D J, AU - Kern,S, AU - Cockerell,C J, PY - 1992/4/1/pubmed PY - 1992/4/1/medline PY - 1992/4/1/entrez SP - 530 EP - 4 JF - Archives of dermatology JO - Arch Dermatol VL - 128 IS - 4 N2 - BACKGROUND: Syphilis has been reported to assume unusual clinical appearances and to exhibit unusual courses in patients infected with the human immunodeficiency virus (HIV) type 1. We recently observed a distinct manifestation of syphilis in an HIV-infected patient with features not previously described. OBSERVATIONS: A 38-year-old HIV-seropositive homosexual man presented with fever, chills, malaise, and a cutaneous eruption consisting of indurated, shiny, erythematous plaques that were confluent on the face and scalp leading to alopecia and extreme tautness of the skin. Initial clinical diagnoses included lymphoreticular malignancy and infection. Although cultures yielded Staphylococcus aureus, a skin biopsy specimen was diagnostic of syphilis. CONCLUSIONS: This case demonstrates an unusual clinical manifestation of syphilis in a patient with HIV infection and emphasizes the importance of considering cutaneous secondary syphilis in the differential diagnosis of virtually any inflammatory cutaneous disorder in HIV-seropositive individuals. SN - 0003-987X UR - https://www.unboundmedicine.com/medline/citation/1580662/An_unusual_presentation_of_secondary_syphilis_in_a_patient_with_human_immunodeficiency_virus_infection__A_case_report_and_review_of_the_literature_ L2 - https://jamanetwork.com/journals/jamadermatology/fullarticle/vol/128/pg/530 DB - PRIME DP - Unbound Medicine ER -