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Effects of protein vs. carbohydrate-rich diets on fuel utilisation in obese women during weight loss.
Forum Nutr 2003; 56:168-70FN

Abstract

BACKGROUND

Energy restriction is a common therapeutic approach for weight reduction, but the most effective macronutrient distribution of the hypoenergetic diet as well as the role of the metabolic processes involved require further investigations.

OBJECTIVE

To study the effect of a high protein (HP) hypoenergetic diet compared with a high carbohydrate (HC) hypoenergetic diet on fuel utilisation changes during the weight loss process in obese women.

DESIGN

Eleven obese (BMI>30) women were randomly assigned to a 10w dietary intervention study comparing HP (30% protein) or HC (55% carbohydrate) energy restricted diets providing 30% energy fat content. Substrate utilisation was evaluated by indirect calorimetry. Body weight and composition (Bod Pod) and blood measurements were performed before and after weight loss.

RESULTS

On average, the individuals on the HP dietary group lost 4.4 kg more than those in the HC program (p<0.50), which was mainly due to a fat mass loss (3.7 kg, p<0.05) with no statistical differences in lean body mass reduction. These losses were accompanied by a significant decrease in fasting leptin in the HP group (-52%; P<0.05). On the other hand post-absorptive lipid oxidation decreased in the HC group (-48%) and remained unchanged in the HP groups.

CONCLUSIONS

The replacement of some dietary carbohydrate by protein in energy restricted diets, improves weight and fat losses and specifically promotes lipid oxidation in the fasting state, without major different in lean body mass depletion.

Authors+Show Affiliations

Department of Physiology and Nutrition, University Clinic University of Navarra, Pamplona, Spain.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15806847

Citation

Labayen, Idoia, et al. "Effects of Protein Vs. Carbohydrate-rich Diets On Fuel Utilisation in Obese Women During Weight Loss." Forum of Nutrition, vol. 56, 2003, pp. 168-70.
Labayen I, Díez N, González A, et al. Effects of protein vs. carbohydrate-rich diets on fuel utilisation in obese women during weight loss. Forum Nutr. 2003;56:168-70.
Labayen, I., Díez, N., González, A., Parra, D., & Martínez, J. A. (2003). Effects of protein vs. carbohydrate-rich diets on fuel utilisation in obese women during weight loss. Forum of Nutrition, 56, pp. 168-70.
Labayen I, et al. Effects of Protein Vs. Carbohydrate-rich Diets On Fuel Utilisation in Obese Women During Weight Loss. Forum Nutr. 2003;56:168-70. PubMed PMID: 15806847.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effects of protein vs. carbohydrate-rich diets on fuel utilisation in obese women during weight loss. AU - Labayen,Idoia, AU - Díez,Nieves, AU - González,Alvaro, AU - Parra,Dolores, AU - Martínez,J Alfredo, PY - 2005/4/6/pubmed PY - 2005/7/13/medline PY - 2005/4/6/entrez SP - 168 EP - 70 JF - Forum of nutrition JO - Forum Nutr VL - 56 N2 - BACKGROUND: Energy restriction is a common therapeutic approach for weight reduction, but the most effective macronutrient distribution of the hypoenergetic diet as well as the role of the metabolic processes involved require further investigations. OBJECTIVE: To study the effect of a high protein (HP) hypoenergetic diet compared with a high carbohydrate (HC) hypoenergetic diet on fuel utilisation changes during the weight loss process in obese women. DESIGN: Eleven obese (BMI>30) women were randomly assigned to a 10w dietary intervention study comparing HP (30% protein) or HC (55% carbohydrate) energy restricted diets providing 30% energy fat content. Substrate utilisation was evaluated by indirect calorimetry. Body weight and composition (Bod Pod) and blood measurements were performed before and after weight loss. RESULTS: On average, the individuals on the HP dietary group lost 4.4 kg more than those in the HC program (p<0.50), which was mainly due to a fat mass loss (3.7 kg, p<0.05) with no statistical differences in lean body mass reduction. These losses were accompanied by a significant decrease in fasting leptin in the HP group (-52%; P<0.05). On the other hand post-absorptive lipid oxidation decreased in the HC group (-48%) and remained unchanged in the HP groups. CONCLUSIONS: The replacement of some dietary carbohydrate by protein in energy restricted diets, improves weight and fat losses and specifically promotes lipid oxidation in the fasting state, without major different in lean body mass depletion. SN - 1660-0347 UR - https://www.unboundmedicine.com/medline/citation/15806847/Effects_of_protein_vs__carbohydrate_rich_diets_on_fuel_utilisation_in_obese_women_during_weight_loss_ L2 - https://medlineplus.gov/obesity.html DB - PRIME DP - Unbound Medicine ER -