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Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women.
Clin Endocrinol (Oxf). 2005 Apr; 62(4):487-91.CE

Abstract

BACKGROUND

A possible relationship between thyroid hormones and adipose tissue metabolism in humans has been suggested. Aim of the study We sought to evaluate thyroid function and its possible relationship with body mass index (BMI), leptin, adiponectin and insulin sensitivity in euthyroid obese women.

MATERIALS AND METHODS

Eighty-seven uncomplicated obese women (mean age 34.7 +/- 9 years, mean BMI 40.1 +/- 7 kg/m(2)) were studied. Levels of TSH, free thyroxine (FT4), free triiodothyronine (FT3), plasma adiponectin and leptin were evaluated. Insulin sensitivity was assessed by euglycaemic hyperinsulinaemic clamp (M index), fasting insulin and HOMA-IR.

RESULTS

Uncomplicated obese women with BMI > 40 kg/m(2) showed higher serum TSH than obese subjects with BMI < 40 kg/m(2) (P < 0.01). TSH was correlated with BMI (r = 0.44, P = 0.01) leptin (r = 0.41, P = 0.01), leptin/BMI ratio (r = 0.33, P = 0.03), body surface area (r = 0.26, P = 0.05), HOMA-IR (r = 0.245, P = 0.05) and inversely with adiponectin (r = -0.25, P = 0.05) and M index (r = -0.223 P = 0.05).

CONCLUSIONS

Our data show that, although thyroid function was normal in the studied obese population, TSH and BMI were positively related. TSH has been found to be correlated also with leptin adjusted for BMI. TSH could represent a marker of altered energy balance in severe, but uncomplicated obese women.

Authors+Show Affiliations

Iacobellis G
Division of Endocrinology, Department of Clinical Sciences, La Sapienza University, Rome, Italy. gianluca.iaco@tin.it
Ribaudo MC
No affiliation info available
Zappaterreno A
No affiliation info available
Iannucci CV
No affiliation info available
Leonetti F
No affiliation info available

MeSH

AdiponectinAdultBody Mass IndexCase-Control StudiesFemaleHumansInsulin ResistanceIntercellular Signaling Peptides and ProteinsLeptinObesityThyroid GlandThyrotropinThyroxineTriiodothyronine

Pub Type(s)

Journal Article

Language

eng

PubMed ID

15807881

Citation

Iacobellis, Gianluca, et al. "Relationship of Thyroid Function With Body Mass Index, Leptin, Insulin Sensitivity and Adiponectin in Euthyroid Obese Women." Clinical Endocrinology, vol. 62, no. 4, 2005, pp. 487-91.
Iacobellis G, Ribaudo MC, Zappaterreno A, et al. Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clin Endocrinol (Oxf). 2005;62(4):487-91.
Iacobellis, G., Ribaudo, M. C., Zappaterreno, A., Iannucci, C. V., & Leonetti, F. (2005). Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. Clinical Endocrinology, 62(4), 487-91.
Iacobellis G, et al. Relationship of Thyroid Function With Body Mass Index, Leptin, Insulin Sensitivity and Adiponectin in Euthyroid Obese Women. Clin Endocrinol (Oxf). 2005;62(4):487-91. PubMed PMID: 15807881.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Relationship of thyroid function with body mass index, leptin, insulin sensitivity and adiponectin in euthyroid obese women. AU - Iacobellis,Gianluca, AU - Ribaudo,Maria Cristina, AU - Zappaterreno,Alessandra, AU - Iannucci,Concetta Valeria, AU - Leonetti,Frida, PY - 2005/4/6/pubmed PY - 2005/7/6/medline PY - 2005/4/6/entrez SP - 487 EP - 91 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 62 IS - 4 N2 - BACKGROUND: A possible relationship between thyroid hormones and adipose tissue metabolism in humans has been suggested. Aim of the study We sought to evaluate thyroid function and its possible relationship with body mass index (BMI), leptin, adiponectin and insulin sensitivity in euthyroid obese women. MATERIALS AND METHODS: Eighty-seven uncomplicated obese women (mean age 34.7 +/- 9 years, mean BMI 40.1 +/- 7 kg/m(2)) were studied. Levels of TSH, free thyroxine (FT4), free triiodothyronine (FT3), plasma adiponectin and leptin were evaluated. Insulin sensitivity was assessed by euglycaemic hyperinsulinaemic clamp (M index), fasting insulin and HOMA-IR. RESULTS: Uncomplicated obese women with BMI > 40 kg/m(2) showed higher serum TSH than obese subjects with BMI < 40 kg/m(2) (P < 0.01). TSH was correlated with BMI (r = 0.44, P = 0.01) leptin (r = 0.41, P = 0.01), leptin/BMI ratio (r = 0.33, P = 0.03), body surface area (r = 0.26, P = 0.05), HOMA-IR (r = 0.245, P = 0.05) and inversely with adiponectin (r = -0.25, P = 0.05) and M index (r = -0.223 P = 0.05). CONCLUSIONS: Our data show that, although thyroid function was normal in the studied obese population, TSH and BMI were positively related. TSH has been found to be correlated also with leptin adjusted for BMI. TSH could represent a marker of altered energy balance in severe, but uncomplicated obese women. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/15807881/Relationship_of_thyroid_function_with_body_mass_index_leptin_insulin_sensitivity_and_adiponectin_in_euthyroid_obese_women_ DB - PRIME DP - Unbound Medicine ER -