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Long-term efficacy of adding a sharp posterior optic edge to a three-piece silicone intraocular lens on capsule opacification: five-year results of a randomized study.
Am J Ophthalmol. 2005 Apr; 139(4):696-703.AJ

Abstract

PURPOSE

To compare the intensity of capsule opacification with the sharp and the round optic edge variant of an open-loop hydrophobic silicone intraocular lens (IOL).

DESIGN

Randomized, controlled, double-blind clinical trial with intraindividual comparison.

METHODS

Fifty-one patients with bilateral age-related cataract were included (102 eyes). Each patient had had cataract surgery in both eyes and received a Microsil IOL with a sharp optic edge design (model S) in one eye and a Microsil IOL with a round optic edge design (model R) in the fellow eye. Both IOLs had an identical haptic design (nonangulated polymethylmethacrylate) and silicone optic material. The patients were examined at the slit lamp, best-corrected visual acuity was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken 5 years after surgery. The intensity of regeneratory posterior capsule opacification (rPCO), fibrotic PCO (fPCO), and anterior capsule opacification (ACO) was assessed subjectively at the slit lamp, and of rPCO, objectively using automated image analysis software (AQUA). The need for an Nd:YAG laser capsulotomy (Nd:YAG-LCT) was noted.

RESULTS

The mean AQUA PCO score was 1.2 for the model S and 2.4 for the model R lens (P = .001). The model S lens also led to less peripheral fPCO (P = .003). Concerning ACO, there was no significant difference between both IOL groups (P = .72). Whereas no capsulotomy was required with the model S, four cases (16%) had been performed in the model R group.

CONCLUSION

Five years postoperatively, the sharp-edged silicone IOL showed less rPCO and fPCO than the round-edged IOL. However, regarding ACO, there was no significant difference between both IOL styles.

Authors+Show Affiliations

Medical University of Vienna, Department of Ophthalmology, Vienna, Austria.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

15808167

Citation

Sacu, Stefan, et al. "Long-term Efficacy of Adding a Sharp Posterior Optic Edge to a Three-piece Silicone Intraocular Lens On Capsule Opacification: Five-year Results of a Randomized Study." American Journal of Ophthalmology, vol. 139, no. 4, 2005, pp. 696-703.
Sacu S, Menapace R, Findl O, et al. Long-term efficacy of adding a sharp posterior optic edge to a three-piece silicone intraocular lens on capsule opacification: five-year results of a randomized study. Am J Ophthalmol. 2005;139(4):696-703.
Sacu, S., Menapace, R., Findl, O., Kiss, B., Buehl, W., & Georgopoulos, M. (2005). Long-term efficacy of adding a sharp posterior optic edge to a three-piece silicone intraocular lens on capsule opacification: five-year results of a randomized study. American Journal of Ophthalmology, 139(4), 696-703.
Sacu S, et al. Long-term Efficacy of Adding a Sharp Posterior Optic Edge to a Three-piece Silicone Intraocular Lens On Capsule Opacification: Five-year Results of a Randomized Study. Am J Ophthalmol. 2005;139(4):696-703. PubMed PMID: 15808167.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Long-term efficacy of adding a sharp posterior optic edge to a three-piece silicone intraocular lens on capsule opacification: five-year results of a randomized study. AU - Sacu,Stefan, AU - Menapace,Rupert, AU - Findl,Oliver, AU - Kiss,Barbara, AU - Buehl,Wolf, AU - Georgopoulos,Michael, PY - 2004/12/16/accepted PY - 2005/4/6/pubmed PY - 2005/4/26/medline PY - 2005/4/6/entrez SP - 696 EP - 703 JF - American journal of ophthalmology JO - Am J Ophthalmol VL - 139 IS - 4 N2 - PURPOSE: To compare the intensity of capsule opacification with the sharp and the round optic edge variant of an open-loop hydrophobic silicone intraocular lens (IOL). DESIGN: Randomized, controlled, double-blind clinical trial with intraindividual comparison. METHODS: Fifty-one patients with bilateral age-related cataract were included (102 eyes). Each patient had had cataract surgery in both eyes and received a Microsil IOL with a sharp optic edge design (model S) in one eye and a Microsil IOL with a round optic edge design (model R) in the fellow eye. Both IOLs had an identical haptic design (nonangulated polymethylmethacrylate) and silicone optic material. The patients were examined at the slit lamp, best-corrected visual acuity was assessed, and standardized high-resolution digital retroillumination images of the posterior capsule were taken 5 years after surgery. The intensity of regeneratory posterior capsule opacification (rPCO), fibrotic PCO (fPCO), and anterior capsule opacification (ACO) was assessed subjectively at the slit lamp, and of rPCO, objectively using automated image analysis software (AQUA). The need for an Nd:YAG laser capsulotomy (Nd:YAG-LCT) was noted. RESULTS: The mean AQUA PCO score was 1.2 for the model S and 2.4 for the model R lens (P = .001). The model S lens also led to less peripheral fPCO (P = .003). Concerning ACO, there was no significant difference between both IOL groups (P = .72). Whereas no capsulotomy was required with the model S, four cases (16%) had been performed in the model R group. CONCLUSION: Five years postoperatively, the sharp-edged silicone IOL showed less rPCO and fPCO than the round-edged IOL. However, regarding ACO, there was no significant difference between both IOL styles. SN - 0002-9394 UR - https://www.unboundmedicine.com/medline/citation/15808167/Long_term_efficacy_of_adding_a_sharp_posterior_optic_edge_to_a_three_piece_silicone_intraocular_lens_on_capsule_opacification:_five_year_results_of_a_randomized_study_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002-9394(04)01593-4 DB - PRIME DP - Unbound Medicine ER -