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Neurovascular mechanisms of Alzheimer's neurodegeneration.
Trends Neurosci 2005; 28(4):202-8TN

Abstract

In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings indicate that neurovascular dysfunction contributes to cognitive decline and neurodegeneration in AD. Here, I propose the neurovascular hypothesis of AD, suggesting that faulty clearance of amyloid beta peptide (A beta) across the blood-brain barrier (BBB), aberrant angiogenesis and senescence of the cerebrovascular system could initiate neurovascular uncoupling, vessel regression, brain hypoperfusion and neurovascular inflammation. Ultimately, this would lead to BBB compromise, to chemical imbalance in the neuronal environment and to synaptic and neuronal dysfunction, injury and loss. Based on the neurovascular hypothesis, I suggest an array of new potential therapeutic approaches that could be developed for AD, to enhance A beta clearance and neurovascular repair, and to protect the neurovascular unit from divergent inducers of injury and apoptosis.

Authors+Show Affiliations

Frank P. Smith Laboratories for Neuroscience and Neurological Surgery Research, Department of Neurological Surgery and Division of Neurovascular Biology, University of Rochester Medical Center, Rochester, NY 14642, USA. berislav_zlokovic@urmc.rochester.edu

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

15808355

Citation

Zlokovic, Berislav V.. "Neurovascular Mechanisms of Alzheimer's Neurodegeneration." Trends in Neurosciences, vol. 28, no. 4, 2005, pp. 202-8.
Zlokovic BV. Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends Neurosci. 2005;28(4):202-8.
Zlokovic, B. V. (2005). Neurovascular mechanisms of Alzheimer's neurodegeneration. Trends in Neurosciences, 28(4), pp. 202-8.
Zlokovic BV. Neurovascular Mechanisms of Alzheimer's Neurodegeneration. Trends Neurosci. 2005;28(4):202-8. PubMed PMID: 15808355.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Neurovascular mechanisms of Alzheimer's neurodegeneration. A1 - Zlokovic,Berislav V, PY - 2005/4/6/pubmed PY - 2005/5/20/medline PY - 2005/4/6/entrez SP - 202 EP - 8 JF - Trends in neurosciences JO - Trends Neurosci. VL - 28 IS - 4 N2 - In contrast to traditional neuroncentric views of Alzheimer's disease (AD), recent findings indicate that neurovascular dysfunction contributes to cognitive decline and neurodegeneration in AD. Here, I propose the neurovascular hypothesis of AD, suggesting that faulty clearance of amyloid beta peptide (A beta) across the blood-brain barrier (BBB), aberrant angiogenesis and senescence of the cerebrovascular system could initiate neurovascular uncoupling, vessel regression, brain hypoperfusion and neurovascular inflammation. Ultimately, this would lead to BBB compromise, to chemical imbalance in the neuronal environment and to synaptic and neuronal dysfunction, injury and loss. Based on the neurovascular hypothesis, I suggest an array of new potential therapeutic approaches that could be developed for AD, to enhance A beta clearance and neurovascular repair, and to protect the neurovascular unit from divergent inducers of injury and apoptosis. SN - 0166-2236 UR - https://www.unboundmedicine.com/medline/citation/15808355/Neurovascular_mechanisms_of_Alzheimer's_neurodegeneration_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0166-2236(05)00045-7 DB - PRIME DP - Unbound Medicine ER -