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Leptin is not involved in the pathophysiology of endometriosis-related infertility.

Abstract

OBJECTIVE

Changes in peritoneal fluid (PF) composition may affect fertilization as well as early embryonic development. Leptin, an adipocyte hormone, has been shown to act as a link between adipose tissue and the reproductive system. Therefore, we decided to assess peritoneal and serum leptin levels in infertile endometriotic patients.

PATIENTS

Seventy-two women were studied, including 30 fertile and 18 infertile women with ovarian endometriotic cysts and, as a reference group, 24 patients with unexplained infertility.

RESULTS

No significant difference in the peritoneal and leptin levels was found between the studied groups. Significantly higher PF leptin concentration was observed in patients with stages III and IV of endometriosis as compared to those with minimal stage of the disease. In fertile patients with endometriosis a positive correlation has been found between PF and serum leptin concentrations.

CONCLUSIONS

No differences in peritoneal or serum leptin levels between infertile and fertile women with endometriosis suggest that this cytokine is not involved in pathophysiology of endometriosis-related infertility.

Authors+Show Affiliations

1st Department of Gynecology, University School of Medicine, ul. Staszica 16, 20-081 Lublin, Poland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

15808381

Citation

Wertel, Iwona, et al. "Leptin Is Not Involved in the Pathophysiology of Endometriosis-related Infertility." European Journal of Obstetrics, Gynecology, and Reproductive Biology, vol. 119, no. 2, 2005, pp. 206-9.
Wertel I, Gogacz M, Polak G, et al. Leptin is not involved in the pathophysiology of endometriosis-related infertility. Eur J Obstet Gynecol Reprod Biol. 2005;119(2):206-9.
Wertel, I., Gogacz, M., Polak, G., Jakowicki, J., & Kotarski, J. (2005). Leptin is not involved in the pathophysiology of endometriosis-related infertility. European Journal of Obstetrics, Gynecology, and Reproductive Biology, 119(2), pp. 206-9.
Wertel I, et al. Leptin Is Not Involved in the Pathophysiology of Endometriosis-related Infertility. Eur J Obstet Gynecol Reprod Biol. 2005 Apr 1;119(2):206-9. PubMed PMID: 15808381.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Leptin is not involved in the pathophysiology of endometriosis-related infertility. AU - Wertel,Iwona, AU - Gogacz,Marek, AU - Polak,Grzegorz, AU - Jakowicki,Jerzy, AU - Kotarski,Jan, PY - 2004/02/06/received PY - 2004/08/12/revised PY - 2004/08/13/accepted PY - 2005/4/6/pubmed PY - 2005/8/6/medline PY - 2005/4/6/entrez SP - 206 EP - 9 JF - European journal of obstetrics, gynecology, and reproductive biology JO - Eur. J. Obstet. Gynecol. Reprod. Biol. VL - 119 IS - 2 N2 - OBJECTIVE: Changes in peritoneal fluid (PF) composition may affect fertilization as well as early embryonic development. Leptin, an adipocyte hormone, has been shown to act as a link between adipose tissue and the reproductive system. Therefore, we decided to assess peritoneal and serum leptin levels in infertile endometriotic patients. PATIENTS: Seventy-two women were studied, including 30 fertile and 18 infertile women with ovarian endometriotic cysts and, as a reference group, 24 patients with unexplained infertility. RESULTS: No significant difference in the peritoneal and leptin levels was found between the studied groups. Significantly higher PF leptin concentration was observed in patients with stages III and IV of endometriosis as compared to those with minimal stage of the disease. In fertile patients with endometriosis a positive correlation has been found between PF and serum leptin concentrations. CONCLUSIONS: No differences in peritoneal or serum leptin levels between infertile and fertile women with endometriosis suggest that this cytokine is not involved in pathophysiology of endometriosis-related infertility. SN - 0301-2115 UR - https://www.unboundmedicine.com/medline/citation/15808381/Leptin_is_not_involved_in_the_pathophysiology_of_endometriosis_related_infertility_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0301-2115(04)00449-X DB - PRIME DP - Unbound Medicine ER -