Tags

Type your tag names separated by a space and hit enter

Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease.
J Am Coll Cardiol. 2005 Apr 05; 45(7):1003-12.JACC

Abstract

OBJECTIVES

This study was designed to explore contributions of plasma total triglycerides (TGs) and type III hyperlipidemia to the risk of premature familial coronary artery disease (CAD).

BACKGROUND

Although plasma TGs are recognized as a risk factor for CAD, the independence of this association from related risk factors remains controversial. Also, the degree of CAD risk conferred by excess remnants of TG-rich lipoproteins in type III hyperlipidemia remains unclear.

METHODS

We analyzed lipids by ultracentrifugation in a series of 653 cases with premature familial CAD (myocardial infarction or revascularization by age 55 years in men or age 65 years in women, with similar onset in at least one other first-degree relative) and in 1,029 control subjects. The relationship of CAD risk to various strata of plasma TGs, high-density lipoprotein (HDL) cholesterol, and type III hyperlipidemia, and interactions among these variables were examined by multiple logistic regression, adjusting for other CAD risk factors.

RESULTS

The odds ratio for CAD with elevated plasma TG rose progressively to 11.4 in those with TGs 500 to 799 mg/dl (95% confidence interval 3.4 to 38.0, p < 0.0001) compared with <100 mg/dl, even after correction for HDL cholesterol, other elements of the metabolic syndrome, and other CAD risk factors. Risk of CAD associated with type III hyperlipidemia (found in 3.4% of cases) was also markedly increased independent of other risk factors (odds ratios of 5 to 10 depending on the model, all with p < 0.002).

CONCLUSIONS

The association between the plasma TG level and premature familial CAD is strong, graded, and independent. Risk of CAD is also strikingly elevated with type III hyperlipidemia.

Authors+Show Affiliations

Cardiovascular Genetics, Department of Internal Medicine, Cardiology Division, University of Utah School of Medicine, 410 Chipeta Way, Salt Lake City, UT 84108, USA. paul@ucvg.med.utah.eduNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

15808755

Citation

Hopkins, Paul N., et al. "Plasma Triglycerides and Type III Hyperlipidemia Are Independently Associated With Premature Familial Coronary Artery Disease." Journal of the American College of Cardiology, vol. 45, no. 7, 2005, pp. 1003-12.
Hopkins PN, Wu LL, Hunt SC, et al. Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease. J Am Coll Cardiol. 2005;45(7):1003-12.
Hopkins, P. N., Wu, L. L., Hunt, S. C., & Brinton, E. A. (2005). Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease. Journal of the American College of Cardiology, 45(7), 1003-12.
Hopkins PN, et al. Plasma Triglycerides and Type III Hyperlipidemia Are Independently Associated With Premature Familial Coronary Artery Disease. J Am Coll Cardiol. 2005 Apr 5;45(7):1003-12. PubMed PMID: 15808755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Plasma triglycerides and type III hyperlipidemia are independently associated with premature familial coronary artery disease. AU - Hopkins,Paul N, AU - Wu,Lily L, AU - Hunt,Steven C, AU - Brinton,Eliot A, PY - 2004/09/01/received PY - 2004/11/22/revised PY - 2004/11/29/accepted PY - 2005/4/6/pubmed PY - 2005/4/23/medline PY - 2005/4/6/entrez SP - 1003 EP - 12 JF - Journal of the American College of Cardiology JO - J Am Coll Cardiol VL - 45 IS - 7 N2 - OBJECTIVES: This study was designed to explore contributions of plasma total triglycerides (TGs) and type III hyperlipidemia to the risk of premature familial coronary artery disease (CAD). BACKGROUND: Although plasma TGs are recognized as a risk factor for CAD, the independence of this association from related risk factors remains controversial. Also, the degree of CAD risk conferred by excess remnants of TG-rich lipoproteins in type III hyperlipidemia remains unclear. METHODS: We analyzed lipids by ultracentrifugation in a series of 653 cases with premature familial CAD (myocardial infarction or revascularization by age 55 years in men or age 65 years in women, with similar onset in at least one other first-degree relative) and in 1,029 control subjects. The relationship of CAD risk to various strata of plasma TGs, high-density lipoprotein (HDL) cholesterol, and type III hyperlipidemia, and interactions among these variables were examined by multiple logistic regression, adjusting for other CAD risk factors. RESULTS: The odds ratio for CAD with elevated plasma TG rose progressively to 11.4 in those with TGs 500 to 799 mg/dl (95% confidence interval 3.4 to 38.0, p < 0.0001) compared with <100 mg/dl, even after correction for HDL cholesterol, other elements of the metabolic syndrome, and other CAD risk factors. Risk of CAD associated with type III hyperlipidemia (found in 3.4% of cases) was also markedly increased independent of other risk factors (odds ratios of 5 to 10 depending on the model, all with p < 0.002). CONCLUSIONS: The association between the plasma TG level and premature familial CAD is strong, graded, and independent. Risk of CAD is also strikingly elevated with type III hyperlipidemia. SN - 0735-1097 UR - https://www.unboundmedicine.com/medline/citation/15808755/Plasma_triglycerides_and_type_III_hyperlipidemia_are_independently_associated_with_premature_familial_coronary_artery_disease_ DB - PRIME DP - Unbound Medicine ER -