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Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: brain microdialysis, behavior, and microscopy.
Peptides. 2005 May; 26(5):827-36.P

Abstract

In the present study, the effect of systemically administered vasoactive intestinal peptide (VIP) (25 ng/kg i.p.) was investigated on drug-induced rotational behavior, extra-cellular dopamine levels and histology of corpus striatum in a 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease. After 15 days of 6-OHDA lesion, apomorphine-induced (0.05 mg/kg s.c.) rotational behavior of the animals significantly increased and extra-cellular dopamine levels of corpus striatum were significantly reduced. VIP reversed the rotational deficits but did not alter the decrease in striatal dopamine levels. On the other hand, histological data indicate that VIP significantly reduced neuronal death and demyelination. Electron microscopic appearance of mast cells showed ultra-structural variety between VIP-treated and 6-OHDA lesioned groups. VIP activates mast cells without any evidence of typical exocytosis, and possibly mast cells could participate in neuroprotection. Our results suggest that systemically administered VIP can attenuate the motor response changes, neuronal cell death, and myelin sheet loss characteristically associated with 12 microg 6-OHDA administration into the rat striatum. Brain mast cells seem to participate in neuronal protection. Possibly, protective cues could be produced by brain mast cells.

Authors+Show Affiliations

Tunçel N
Osmangazi University, Medical Faculty, Physiology Department, 26480 Eskişehir, Turkey. ntuncel@ogu.edu.tr
Sener E
No affiliation info available
Cerit C
No affiliation info available
Karasu U
No affiliation info available
Gürer F
No affiliation info available
Sahintürk V
No affiliation info available
Bayçu C
No affiliation info available
Ak D
No affiliation info available
Filiz Z
No affiliation info available

MeSH

AnimalsBehavior, AnimalBrainDisease Models, AnimalDopamineMast CellsMicrodialysisNeuroprotective AgentsParkinson Disease, SecondaryRatsVasoactive Intestinal Peptide

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15808913

Citation

Tunçel, Neşe, et al. "Brain Mast Cells and Therapeutic Potential of Vasoactive Intestinal Peptide in a Parkinson's Disease Model in Rats: Brain Microdialysis, Behavior, and Microscopy." Peptides, vol. 26, no. 5, 2005, pp. 827-36.
Tunçel N, Sener E, Cerit C, et al. Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: brain microdialysis, behavior, and microscopy. Peptides. 2005;26(5):827-36.
Tunçel, N., Sener, E., Cerit, C., Karasu, U., Gürer, F., Sahintürk, V., Bayçu, C., Ak, D., & Filiz, Z. (2005). Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: brain microdialysis, behavior, and microscopy. Peptides, 26(5), 827-36.
Tunçel N, et al. Brain Mast Cells and Therapeutic Potential of Vasoactive Intestinal Peptide in a Parkinson's Disease Model in Rats: Brain Microdialysis, Behavior, and Microscopy. Peptides. 2005;26(5):827-36. PubMed PMID: 15808913.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Brain mast cells and therapeutic potential of vasoactive intestinal peptide in a Parkinson's disease model in rats: brain microdialysis, behavior, and microscopy. AU - Tunçel,Neşe, AU - Sener,Erol, AU - Cerit,Cem, AU - Karasu,Umut, AU - Gürer,Firdevs, AU - Sahintürk,Varol, AU - Bayçu,Cengiz, AU - Ak,Dilek, AU - Filiz,Zeynep, PY - 2004/10/22/received PY - 2004/12/22/revised PY - 2004/12/22/accepted PY - 2005/4/6/pubmed PY - 2005/9/28/medline PY - 2005/4/6/entrez SP - 827 EP - 36 JF - Peptides JO - Peptides VL - 26 IS - 5 N2 - In the present study, the effect of systemically administered vasoactive intestinal peptide (VIP) (25 ng/kg i.p.) was investigated on drug-induced rotational behavior, extra-cellular dopamine levels and histology of corpus striatum in a 6-hydroxydopamine (6-OHDA)-induced rat model of Parkinson's disease. After 15 days of 6-OHDA lesion, apomorphine-induced (0.05 mg/kg s.c.) rotational behavior of the animals significantly increased and extra-cellular dopamine levels of corpus striatum were significantly reduced. VIP reversed the rotational deficits but did not alter the decrease in striatal dopamine levels. On the other hand, histological data indicate that VIP significantly reduced neuronal death and demyelination. Electron microscopic appearance of mast cells showed ultra-structural variety between VIP-treated and 6-OHDA lesioned groups. VIP activates mast cells without any evidence of typical exocytosis, and possibly mast cells could participate in neuroprotection. Our results suggest that systemically administered VIP can attenuate the motor response changes, neuronal cell death, and myelin sheet loss characteristically associated with 12 microg 6-OHDA administration into the rat striatum. Brain mast cells seem to participate in neuronal protection. Possibly, protective cues could be produced by brain mast cells. SN - 0196-9781 UR - https://www.unboundmedicine.com/medline/citation/15808913/Brain_mast_cells_and_therapeutic_potential_of_vasoactive_intestinal_peptide_in_a_Parkinson's_disease_model_in_rats:_brain_microdialysis_behavior_and_microscopy_ DB - PRIME DP - Unbound Medicine ER -