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Hormonal and metabolic responses to acute ghrelin administration in patients with bulimia nervosa.
Psychoneuroendocrinology. 2005 Jul; 30(6):534-40.P

Abstract

Ghrelin is generally influenced by energy balance status and is inversely associated with body mass index (BMI), being reduced in simple obesity, notable exception being Prader Willi syndrome, and elevated in several conditions of undernutrition, including anorexia nervosa (AN). Interestingly, ghrelin levels have also been found elevated in patients with bulimia nervosa (BN) in spite of normal BMI. In humans, intravenous (iv) ghrelin administration induces endocrine (increase in GH, PRL, ACTH and cortisol) and metabolic (increase in glucose and decrease in insulin) effects as well as an increase in appetite and food intake. In AN, ghrelin administration surprisingly leads to a decreased GH response and absence of glycemic variations but normal PRL, ACTH and insulin response. This pattern would reflect a decrease in sensitivity to ghrelin or, alternatively, the metabolic status of AN. To further clarify the function of ghrelin in eating disorders, the endocrine and metabolic response to acute iv ghrelin (1.0 microg/kg) was studied in seven young women with purging BN (BW, BMI, mean+/-SEM: 20.3+/-0.5 kg/m2). Circulating total ghrelin levels were also measured. The results in BW were compared to those recorded in a group of nine healthy women (HW; BMI 22.3+/-2.5 kg/m2). The GH response to ghrelin in BW overlapped with that in HW. Ghrelin administration also led to a similar increase in PRL, ACTH, cortisol and glucose levels in the two groups. Insulin levels were not significantly modified by ghrelin administration in either group. The overlapping endocrine and metabolic response to ghrelin in the two groups occurred with regard to circulating total ghrelin levels which were higher in BW than in HW. In conclusion, BN, a condition of ghrelin hypersecretion, is connoted by a normal endocrine and metabolic response to exogenous ghrelin administration.

Authors+Show Affiliations

Division of Psychiatry, Department of Neuroscience, University of Turin, Via Cherasco 11, 10126 Turin, Italy. secondo.fassino@unito.itNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Controlled Clinical Trial
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15808922

Citation

Fassino, S, et al. "Hormonal and Metabolic Responses to Acute Ghrelin Administration in Patients With Bulimia Nervosa." Psychoneuroendocrinology, vol. 30, no. 6, 2005, pp. 534-40.
Fassino S, Daga GA, Mondelli V, et al. Hormonal and metabolic responses to acute ghrelin administration in patients with bulimia nervosa. Psychoneuroendocrinology. 2005;30(6):534-40.
Fassino, S., Daga, G. A., Mondelli, V., Pierò, A., Broglio, F., Picu, A., Giordano, R., Baldi, M., Arvat, E., Ghigo, E., & Gianotti, L. (2005). Hormonal and metabolic responses to acute ghrelin administration in patients with bulimia nervosa. Psychoneuroendocrinology, 30(6), 534-40.
Fassino S, et al. Hormonal and Metabolic Responses to Acute Ghrelin Administration in Patients With Bulimia Nervosa. Psychoneuroendocrinology. 2005;30(6):534-40. PubMed PMID: 15808922.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Hormonal and metabolic responses to acute ghrelin administration in patients with bulimia nervosa. AU - Fassino,S, AU - Daga,G Abbate, AU - Mondelli,V, AU - Pierò,A, AU - Broglio,F, AU - Picu,A, AU - Giordano,R, AU - Baldi,M, AU - Arvat,E, AU - Ghigo,E, AU - Gianotti,L, PY - 2004/07/01/received PY - 2004/12/19/revised PY - 2004/12/22/accepted PY - 2005/4/6/pubmed PY - 2005/7/6/medline PY - 2005/4/6/entrez SP - 534 EP - 40 JF - Psychoneuroendocrinology JO - Psychoneuroendocrinology VL - 30 IS - 6 N2 - Ghrelin is generally influenced by energy balance status and is inversely associated with body mass index (BMI), being reduced in simple obesity, notable exception being Prader Willi syndrome, and elevated in several conditions of undernutrition, including anorexia nervosa (AN). Interestingly, ghrelin levels have also been found elevated in patients with bulimia nervosa (BN) in spite of normal BMI. In humans, intravenous (iv) ghrelin administration induces endocrine (increase in GH, PRL, ACTH and cortisol) and metabolic (increase in glucose and decrease in insulin) effects as well as an increase in appetite and food intake. In AN, ghrelin administration surprisingly leads to a decreased GH response and absence of glycemic variations but normal PRL, ACTH and insulin response. This pattern would reflect a decrease in sensitivity to ghrelin or, alternatively, the metabolic status of AN. To further clarify the function of ghrelin in eating disorders, the endocrine and metabolic response to acute iv ghrelin (1.0 microg/kg) was studied in seven young women with purging BN (BW, BMI, mean+/-SEM: 20.3+/-0.5 kg/m2). Circulating total ghrelin levels were also measured. The results in BW were compared to those recorded in a group of nine healthy women (HW; BMI 22.3+/-2.5 kg/m2). The GH response to ghrelin in BW overlapped with that in HW. Ghrelin administration also led to a similar increase in PRL, ACTH, cortisol and glucose levels in the two groups. Insulin levels were not significantly modified by ghrelin administration in either group. The overlapping endocrine and metabolic response to ghrelin in the two groups occurred with regard to circulating total ghrelin levels which were higher in BW than in HW. In conclusion, BN, a condition of ghrelin hypersecretion, is connoted by a normal endocrine and metabolic response to exogenous ghrelin administration. SN - 0306-4530 UR - https://www.unboundmedicine.com/medline/citation/15808922/Hormonal_and_metabolic_responses_to_acute_ghrelin_administration_in_patients_with_bulimia_nervosa_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0306-4530(05)00004-1 DB - PRIME DP - Unbound Medicine ER -