Tags

Type your tag names separated by a space and hit enter

Ejaculation induces long-lasting behavioural changes in male rats in the forced swimming test: evidence for an increased sensitivity to the antidepressant desipramine.
Brain Res Bull. 2005 Apr 30; 65(4):323-9.BR

Abstract

Copulation to exhaustion induces a sexual inhibitory state featured by a decreased motivation. Since diminished motivation is a key symptom of depression, we analysed if sexually exhausted animals showed increased levels of depressive-like behaviour in the forced swimming test (FST). Besides, sexual activity has been reported to have reinforcing properties. Thus, we analysed whether different levels of sexual activity modified the development of the behavioural despair in the FST. Finally, the effect of a sub-threshold dose of desipramine (DMI, 2.5mg/kg) was evaluated in animals with different sexual conditions. Male adult rats were divided into: (a) naive rats and (b) animals executing one intromission (1-INTR) or (c) one ejaculation (1-EJ) and (d) sexually satiated rats, classified as sexually responsive (R) and non-responsive (NR). No differences were found in immobility behaviour between sexually exhausted and naive rats. In the pre-test sessions of the FST males attaining ejaculation (1-EJ, R and NR) had lower levels of immobility or showed a tendency towards such a diminution, while animals with sexual activity not involving ejaculation did not. Data suggest a "protective" effect of ejaculation against the development of depressive-like behaviour. Finally, the sub-effective dose of DMI produced an antidepressant-like action in all animals that ejaculated. In conclusion, sexual experience involving ejaculation modifies the behavioural expression of rats in the FST and their sensitivity to antidepressant drugs like DMI. Both responses reflect brain plastic changes induced by ejaculation.

Authors+Show Affiliations

Subdirección de Neurociencias, Instituto Nacional de Psiquiatría Ramón de la Fuente, Av. México-Xochimilco 101, San Lorenzo Huipulco, C.P. 14370, México D.F., Mexico.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15811598

Citation

Martínez-Mota, Lucía, et al. "Ejaculation Induces Long-lasting Behavioural Changes in Male Rats in the Forced Swimming Test: Evidence for an Increased Sensitivity to the Antidepressant Desipramine." Brain Research Bulletin, vol. 65, no. 4, 2005, pp. 323-9.
Martínez-Mota L, López-Rubalcava C, Rodríguez-Manzo G. Ejaculation induces long-lasting behavioural changes in male rats in the forced swimming test: evidence for an increased sensitivity to the antidepressant desipramine. Brain Res Bull. 2005;65(4):323-9.
Martínez-Mota, L., López-Rubalcava, C., & Rodríguez-Manzo, G. (2005). Ejaculation induces long-lasting behavioural changes in male rats in the forced swimming test: evidence for an increased sensitivity to the antidepressant desipramine. Brain Research Bulletin, 65(4), 323-9.
Martínez-Mota L, López-Rubalcava C, Rodríguez-Manzo G. Ejaculation Induces Long-lasting Behavioural Changes in Male Rats in the Forced Swimming Test: Evidence for an Increased Sensitivity to the Antidepressant Desipramine. Brain Res Bull. 2005 Apr 30;65(4):323-9. PubMed PMID: 15811598.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Ejaculation induces long-lasting behavioural changes in male rats in the forced swimming test: evidence for an increased sensitivity to the antidepressant desipramine. AU - Martínez-Mota,Lucía, AU - López-Rubalcava,Carolina, AU - Rodríguez-Manzo,Gabriela, PY - 2004/02/28/received PY - 2004/11/12/revised PY - 2004/12/06/accepted PY - 2005/4/7/pubmed PY - 2005/6/18/medline PY - 2005/4/7/entrez SP - 323 EP - 9 JF - Brain research bulletin JO - Brain Res. Bull. VL - 65 IS - 4 N2 - Copulation to exhaustion induces a sexual inhibitory state featured by a decreased motivation. Since diminished motivation is a key symptom of depression, we analysed if sexually exhausted animals showed increased levels of depressive-like behaviour in the forced swimming test (FST). Besides, sexual activity has been reported to have reinforcing properties. Thus, we analysed whether different levels of sexual activity modified the development of the behavioural despair in the FST. Finally, the effect of a sub-threshold dose of desipramine (DMI, 2.5mg/kg) was evaluated in animals with different sexual conditions. Male adult rats were divided into: (a) naive rats and (b) animals executing one intromission (1-INTR) or (c) one ejaculation (1-EJ) and (d) sexually satiated rats, classified as sexually responsive (R) and non-responsive (NR). No differences were found in immobility behaviour between sexually exhausted and naive rats. In the pre-test sessions of the FST males attaining ejaculation (1-EJ, R and NR) had lower levels of immobility or showed a tendency towards such a diminution, while animals with sexual activity not involving ejaculation did not. Data suggest a "protective" effect of ejaculation against the development of depressive-like behaviour. Finally, the sub-effective dose of DMI produced an antidepressant-like action in all animals that ejaculated. In conclusion, sexual experience involving ejaculation modifies the behavioural expression of rats in the FST and their sensitivity to antidepressant drugs like DMI. Both responses reflect brain plastic changes induced by ejaculation. SN - 0361-9230 UR - https://www.unboundmedicine.com/medline/citation/15811598/Ejaculation_induces_long_lasting_behavioural_changes_in_male_rats_in_the_forced_swimming_test:_evidence_for_an_increased_sensitivity_to_the_antidepressant_desipramine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0361-9230(05)00018-3 DB - PRIME DP - Unbound Medicine ER -