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Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database.
Blood. 2005 Jul 15; 106(2):668-72.Blood

Abstract

Non-Hodgkin lymphoma (NHL) consists of a heterogeneous group of tumors. Population-based data on the familial risk for specific histopathologic subtypes have not been established. Such data are useful for clinical counseling and for searching tumor subtypes sharing common genetic pathways. We used the Swedish Family-Cancer Database to calculate standardized incidence ratios (SIRs) for histopathology-specific subtypes of NHL in 4455 offspring with NHL whose parents or siblings were affected with different types of lymphoproliferative malignancies. A familial history of NHL significantly increased the risk for NHL (SIRparent = 1.8; SIRsibling = 1.9) and for diffuse large B-cell lymphoma (SIRparent = 2.3), follicular lymphoma (SIRsibling = 2.3), and B-cell lymphoma not otherwise specified (NOS) (SIRsibling = 3.4). For a parental history of histopathology-specific concordant cancer, the risks were significantly increased for diffuse large B-cell lymphoma (SIR = 11.8), follicular NHL (SIR = 6.1), plasma cell myeloma (SIR = 2.5), and chronic lymphocytic leukemia (SIR = 5.9). Familial clusters for NHL seemed stronger in females and in siblings. Our study provides the first quantification of the familial risks for NHL by histopathology. The present findings give evidence for a strong familial association of NHL, with little differences in the magnitude of risks for various histopathologic subtypes. The patterns of risks in parents and siblings support the hypothesis of an autosomal-dominant component for diffuse large B-cell NHL and a recessive one for follicular NHL.

Authors+Show Affiliations

Division of Molecular Genetic Epidemiology, German Cancer Research Centre, Heidelberg, Germany. a.altieri@dkfz-heidelberg.deNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15811955

Citation

Altieri, Andrea, et al. "Familial Risk for non-Hodgkin Lymphoma and Other Lymphoproliferative Malignancies By Histopathologic Subtype: the Swedish Family-Cancer Database." Blood, vol. 106, no. 2, 2005, pp. 668-72.
Altieri A, Bermejo JL, Hemminki K. Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database. Blood. 2005;106(2):668-72.
Altieri, A., Bermejo, J. L., & Hemminki, K. (2005). Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database. Blood, 106(2), 668-72.
Altieri A, Bermejo JL, Hemminki K. Familial Risk for non-Hodgkin Lymphoma and Other Lymphoproliferative Malignancies By Histopathologic Subtype: the Swedish Family-Cancer Database. Blood. 2005 Jul 15;106(2):668-72. PubMed PMID: 15811955.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Familial risk for non-Hodgkin lymphoma and other lymphoproliferative malignancies by histopathologic subtype: the Swedish Family-Cancer Database. AU - Altieri,Andrea, AU - Bermejo,Justo Lorenzo, AU - Hemminki,Kari, Y1 - 2005/04/05/ PY - 2005/4/7/pubmed PY - 2005/8/19/medline PY - 2005/4/7/entrez SP - 668 EP - 72 JF - Blood JO - Blood VL - 106 IS - 2 N2 - Non-Hodgkin lymphoma (NHL) consists of a heterogeneous group of tumors. Population-based data on the familial risk for specific histopathologic subtypes have not been established. Such data are useful for clinical counseling and for searching tumor subtypes sharing common genetic pathways. We used the Swedish Family-Cancer Database to calculate standardized incidence ratios (SIRs) for histopathology-specific subtypes of NHL in 4455 offspring with NHL whose parents or siblings were affected with different types of lymphoproliferative malignancies. A familial history of NHL significantly increased the risk for NHL (SIRparent = 1.8; SIRsibling = 1.9) and for diffuse large B-cell lymphoma (SIRparent = 2.3), follicular lymphoma (SIRsibling = 2.3), and B-cell lymphoma not otherwise specified (NOS) (SIRsibling = 3.4). For a parental history of histopathology-specific concordant cancer, the risks were significantly increased for diffuse large B-cell lymphoma (SIR = 11.8), follicular NHL (SIR = 6.1), plasma cell myeloma (SIR = 2.5), and chronic lymphocytic leukemia (SIR = 5.9). Familial clusters for NHL seemed stronger in females and in siblings. Our study provides the first quantification of the familial risks for NHL by histopathology. The present findings give evidence for a strong familial association of NHL, with little differences in the magnitude of risks for various histopathologic subtypes. The patterns of risks in parents and siblings support the hypothesis of an autosomal-dominant component for diffuse large B-cell NHL and a recessive one for follicular NHL. SN - 0006-4971 UR - https://www.unboundmedicine.com/medline/citation/15811955/Familial_risk_for_non_Hodgkin_lymphoma_and_other_lymphoproliferative_malignancies_by_histopathologic_subtype:_the_Swedish_Family_Cancer_Database_ L2 - https://ashpublications.org/blood/article-lookup/doi/10.1182/blood-2005-01-0140 DB - PRIME DP - Unbound Medicine ER -