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Importance of magnesium in absorption and excretion of oxalate.
Urol Int 2005; 74(3):262-7UI

Abstract

INTRODUCTION

Magnesium treatment for calcium oxalate urolithiasis is discussed controversially. The aim of this study was to investigate the influence of magnesium supplementation on the oxalate absorption.

MATERIALS AND METHODS

The [13C2]oxalate absorption test was always performed three times in 6 healthy volunteers under standardized conditions, with one 10-mmol magnesium supplement together with the labeled oxalate and with two 10-mmol magnesium supplements given in 12-hour intervals.

RESULTS

The mean intestinal oxalate absorption under standard conditions was 8.6 +/- 2.83%. The oxalate absorption with one 10-mmol magnesium supplement was 5.2 +/- 1.40% and with two supplements 5.5 +/- 1.62%. Both decreases were statistically significant relative to the standard test, however, not significantly different from each other.

CONCLUSIONS

The results show that magnesium administration decreases the oxalate absorption, when magnesium is taken together with oxalate. However, magnesium administration does not decrease the oxalate absorption, when magnesium and oxalate intake differ by 12 h.

Authors+Show Affiliations

Division of Experimental Urology, Department of Urology, University of Bonn, DE-53105 Bonn, Germany. Zimmermann@uni-bonn.deNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15812215

Citation

Zimmermann, Diana J., et al. "Importance of Magnesium in Absorption and Excretion of Oxalate." Urologia Internationalis, vol. 74, no. 3, 2005, pp. 262-7.
Zimmermann DJ, Voss S, von Unruh GE, et al. Importance of magnesium in absorption and excretion of oxalate. Urol Int. 2005;74(3):262-7.
Zimmermann, D. J., Voss, S., von Unruh, G. E., & Hesse, A. (2005). Importance of magnesium in absorption and excretion of oxalate. Urologia Internationalis, 74(3), pp. 262-7.
Zimmermann DJ, et al. Importance of Magnesium in Absorption and Excretion of Oxalate. Urol Int. 2005;74(3):262-7. PubMed PMID: 15812215.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Importance of magnesium in absorption and excretion of oxalate. AU - Zimmermann,Diana J, AU - Voss,Susanne, AU - von Unruh,Gerd E, AU - Hesse,Albrecht, PY - 2003/11/05/received PY - 2004/09/03/accepted PY - 2005/4/7/pubmed PY - 2005/7/6/medline PY - 2005/4/7/entrez SP - 262 EP - 7 JF - Urologia internationalis JO - Urol. Int. VL - 74 IS - 3 N2 - INTRODUCTION: Magnesium treatment for calcium oxalate urolithiasis is discussed controversially. The aim of this study was to investigate the influence of magnesium supplementation on the oxalate absorption. MATERIALS AND METHODS: The [13C2]oxalate absorption test was always performed three times in 6 healthy volunteers under standardized conditions, with one 10-mmol magnesium supplement together with the labeled oxalate and with two 10-mmol magnesium supplements given in 12-hour intervals. RESULTS: The mean intestinal oxalate absorption under standard conditions was 8.6 +/- 2.83%. The oxalate absorption with one 10-mmol magnesium supplement was 5.2 +/- 1.40% and with two supplements 5.5 +/- 1.62%. Both decreases were statistically significant relative to the standard test, however, not significantly different from each other. CONCLUSIONS: The results show that magnesium administration decreases the oxalate absorption, when magnesium is taken together with oxalate. However, magnesium administration does not decrease the oxalate absorption, when magnesium and oxalate intake differ by 12 h. SN - 0042-1138 UR - https://www.unboundmedicine.com/medline/citation/15812215/Importance_of_magnesium_in_absorption_and_excretion_of_oxalate_ L2 - https://www.karger.com?DOI=10.1159/000083560 DB - PRIME DP - Unbound Medicine ER -