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Gabapentin in the treatment of antipsychotic-induced akathisia in schizophrenia.
Int Clin Psychopharmacol. 2005 May; 20(3):179-81.IC

Abstract

Antipsychotic-induced akathisia is characterized by subjective and objective motor restlessness, which is observed as a common extrapyramidal side-effect of antipsychotic agents. A patient is described who had antipsychotic-induced akathisia unresponsive to conventional therapy, and who began gabapentin therapy for insomnia. Significant improvement in his akathisia occurred when the gabapentin dose was increased, and his other treatment for akathisia was decreased and discontinued. Gabapentin may be effective by mechanisms similar to its action in restless legs syndrome and Parkinsonism, and/or via the GABA neurotransmitter system.

Authors+Show Affiliations

Faculty of Medicine, McGill University, Montreal, Quebec, Canada.No affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15812271

Citation

Pfeffer, Gerald, et al. "Gabapentin in the Treatment of Antipsychotic-induced Akathisia in Schizophrenia." International Clinical Psychopharmacology, vol. 20, no. 3, 2005, pp. 179-81.
Pfeffer G, Chouinard G, Margolese HC. Gabapentin in the treatment of antipsychotic-induced akathisia in schizophrenia. Int Clin Psychopharmacol. 2005;20(3):179-81.
Pfeffer, G., Chouinard, G., & Margolese, H. C. (2005). Gabapentin in the treatment of antipsychotic-induced akathisia in schizophrenia. International Clinical Psychopharmacology, 20(3), 179-81.
Pfeffer G, Chouinard G, Margolese HC. Gabapentin in the Treatment of Antipsychotic-induced Akathisia in Schizophrenia. Int Clin Psychopharmacol. 2005;20(3):179-81. PubMed PMID: 15812271.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Gabapentin in the treatment of antipsychotic-induced akathisia in schizophrenia. AU - Pfeffer,Gerald, AU - Chouinard,Guy, AU - Margolese,Howard C, PY - 2005/4/7/pubmed PY - 2005/8/3/medline PY - 2005/4/7/entrez SP - 179 EP - 81 JF - International clinical psychopharmacology JO - Int Clin Psychopharmacol VL - 20 IS - 3 N2 - Antipsychotic-induced akathisia is characterized by subjective and objective motor restlessness, which is observed as a common extrapyramidal side-effect of antipsychotic agents. A patient is described who had antipsychotic-induced akathisia unresponsive to conventional therapy, and who began gabapentin therapy for insomnia. Significant improvement in his akathisia occurred when the gabapentin dose was increased, and his other treatment for akathisia was decreased and discontinued. Gabapentin may be effective by mechanisms similar to its action in restless legs syndrome and Parkinsonism, and/or via the GABA neurotransmitter system. SN - 0268-1315 UR - https://www.unboundmedicine.com/medline/citation/15812271/Gabapentin_in_the_treatment_of_antipsychotic_induced_akathisia_in_schizophrenia_ L2 - https://doi.org/10.1097/00004850-200505000-00011 DB - PRIME DP - Unbound Medicine ER -