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Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study.
Br J Cancer. 2005 Apr 11; 92(7):1310-20.BJ

Abstract

Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G>A transitions in rectal tumours.

Authors+Show Affiliations

Nutrition and Toxicology Research Institute Maastricht (NUTRIM), Department of Epidemiology, Maastricht University, PO Box 616, 6200 MD, Maastricht, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

15812479

Citation

Brink, M, et al. "Meat Consumption and K-ras Mutations in Sporadic Colon and Rectal Cancer in the Netherlands Cohort Study." British Journal of Cancer, vol. 92, no. 7, 2005, pp. 1310-20.
Brink M, Weijenberg MP, de Goeij AF, et al. Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. Br J Cancer. 2005;92(7):1310-20.
Brink, M., Weijenberg, M. P., de Goeij, A. F., Roemen, G. M., Lentjes, M. H., de Bruïne, A. P., Goldbohm, R. A., & van den Brandt, P. A. (2005). Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. British Journal of Cancer, 92(7), 1310-20.
Brink M, et al. Meat Consumption and K-ras Mutations in Sporadic Colon and Rectal Cancer in the Netherlands Cohort Study. Br J Cancer. 2005 Apr 11;92(7):1310-20. PubMed PMID: 15812479.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Meat consumption and K-ras mutations in sporadic colon and rectal cancer in The Netherlands Cohort Study. AU - Brink,M, AU - Weijenberg,M P, AU - de Goeij,A F P M, AU - Roemen,G M J M, AU - Lentjes,M H F M, AU - de Bruïne,A P, AU - Goldbohm,R A, AU - van den Brandt,P A, PY - 2005/4/7/pubmed PY - 2005/5/27/medline PY - 2005/4/7/entrez SP - 1310 EP - 20 JF - British journal of cancer JO - Br. J. Cancer VL - 92 IS - 7 N2 - Case-cohort analyses were performed on meat and fish consumption in relation to K-ras mutations in 448 colon and 160 rectal cancers that occurred during 7.3 years of follow-up, excluding the first 2.3 years, and 2948 subcohort members of The Netherlands Cohort Study on diet and cancer. Adjusted incidence rate ratios and 95% confidence intervals were computed for colon and rectal cancer and for K-ras mutation status subgroups. Total fresh meat, most types of fresh meat and fish were not associated with colon or rectal cancer, neither overall nor with K-ras mutation status. However, several weak associations were observed for tumours with a wild-type K-ras, including beef and colon tumours, and an inverse association for pork with colon and rectal tumours; for meat products, an increased association was observed with wild-type K-ras tumours in the colon and possibly with G>A transitions in rectal tumours. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/15812479/Meat_consumption_and_K_ras_mutations_in_sporadic_colon_and_rectal_cancer_in_The_Netherlands_Cohort_Study_ L2 - http://dx.doi.org/10.1038/sj.bjc.6602491 DB - PRIME DP - Unbound Medicine ER -